Drug Metabolite
Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
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Drug Metabolite Related Products (2022)
Related Products (2022)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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(S)-(+)-O-Desmethyl Venlafaxine-d6
0 Images(S)-(+)-O-Desmethyl Venlafaxine-d6 is the deuterium labeled (S)-(+)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine. Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.
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Norverapamil hydrochloride (Standard)
0 ImagesCat. No.: HY-100750RCAS No.: 67812-42-4Synonyms: (±)-Norverapamil hydrochloride (Standard); D591 hydrochloride (Standard)Norverapamil (hydrochloride) (Standard) is the analytical standard of Norverapamil (hydrochloride). This product is intended for research and analytical applications. Norverapamil hydrochloride ((±)-Norverapamil hydrochloride), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].
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4'-Hydroxytamoxifen-d6 (contains up to 10% E isomer)
0 ImagesCat. No.: HY-124414SCAS No.: 1346606-80-14'-Hydroxytamoxifen-d6 (contains up to 10% E isomer) is deuterium labeled 4'-Hydroxy Tamoxifen. 4'-Hydroxytamoxifen is a metabolite of Tamoxifen.
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CIT-ALD
0 ImagesCat. No.: HY-172985CAS No.: 211800-31-6CIT-ALD is an aldehyde intermediate in the metabolism of Citalopram (HY-121203). CIT-ALD is promising for research of neurological diseases.
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Bradykinin (1-5) TFA
0 ImagesCat. No.: HY-P1488ABradykinin (1-5) TFA is a metabolite of Bradykinin (HY-P0206) and a PAR inhibitor that inhibits thrombin-induced platelet aggregation by preventing protease-activated receptor (Protease Activated Receptor) cleavage and inhibiting Thrombin (MW 37kDa) (HY-114164). Bradykinin (1-5) TFA is used in research on thrombosis, carrageenan-induced pleurisy, nasal allergy, and hereditary angioedema.
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NM-002
0 ImagesCat. No.: HY-178820NM-002 is a metabolite of prodrug NM-001 (HY-178819), with NIR emission. NM-002 generates through activates the prodrug NM-001 by overexpressed Cathepsin B (CTSB) within tumor cells. NM-002 has no toxicity towards tumor cells and can escape from the lysosomes into the cytoplasm. NM-002 can be used for real-time drug release monitoring research.
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Ivabradine impurity 2
0 ImagesCat. No.: HY-131282CAS No.: 73954-34-4Ivabradine impurity 2 is an Ivabradine impurity. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker.
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Lansoprazole sulfone (Standard)
0 ImagesCat. No.: HY-W008614RCAS No.: 131926-99-3Synonyms: AG-1813 (Standard)Lansoprazole sulfone (AG-1813) (Standard) is the analytical standard of Lansoprazole sulfone (HY-W008614). This product is intended for research and analytical applications. Lansoprazole sulfone, Lansoprazole (HY-13662) metabolite, is a H+, K+-ATPase inhibitor. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease.
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2-(Methylamino)benzoic acid (Standard)
0 ImagesSynonyms: N-Methylanthranilic acid (Standard)2-(Methylamino)benzoic acid (Standard) is the analytical standard of 2-(Methylamino)benzoic acid. This product is intended for research and analytical applications. 2-(Methylamino)benzoic acid is the main metabolite of methyl-N-methylanthranilates (MMA) (HY-76705) and is the compound in which the ester group is converted. MMA can be isolated from citrus fruits and has potential analgesic activity. 2-(Methylamino)benzoic acid was used to detect the metabolic levels of MMA in rat liver[1].
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7-Hydroxymethotrexate-d3 ammonium
0 ImagesCat. No.: HY-130569S27-Hydroxymethotrexate-d3 (ammonium) is the deuterium labeled 7-Hydroxymethotrexate ammonium. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.
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NAPQI-d3
0 ImagesCat. No.: HY-W744265Synonyms: N-Acetyl-4-benzoquinone Imine-d3NAPQI-d3 (N-Acetyl-4-benzoquinone Imine-d3) is the deuterium labeled NAPQI (HY-W017464). NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver.
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Z-Doxepin-d3 Hydrochloride
0 ImagesCat. No.: HY-W704752CAS No.: 2469242-68-8Z-Doxepin-d3 hydrochloride is the deuterium labeled 7-Hydroxychlorpromazine hydrochloride (HY-W704749). 7-Hydroxychlorpromazine hydrochloride is the active metabolite of Chlorpromazine (HY-12708). 7-Hydroxychlorpromazine hydrochloride can increase prolactin levels in rats. 7-Hydroxychlorpromazine hydrochloride can increase dopamine turnover and has a sedative effect. In addition, 7-Hydroxychlorpromazine hydrochloride can effectively inhibit amphetamine-induced stereotyped behavior in rats and is used in the study of psychosis.
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Dopal (purity>80%)
0 ImagesCat. No.: HY-121252ACAS No.: 5707-55-1Dopal (purity>80%) is a metabolite and aldehyde neurotoxin of Dopamine (HY-B0451). Dopal (purity>80%) exhibits cytotoxicity, induces α-synuclein oligomerization and aggregation, and is closely associated with the pathogenesis of Parkinson's disease. Dopal (purity>80%) can be used in research related to Parkinson's disease.
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Acetaminophen metabolite 3-hydroxy-acetaminophen (Standard)
0 ImagesSynonyms: 3-Hydroxyacetaminophen (Standard)Acetaminophen metabolite 3-hydroxy-acetaminophen (3-Hydroxyacetaminophen) (Standard) is the analytical standard of Acetaminophen metabolite 3-hydroxy-acetaminophen (HY-G0004). This product is intended for research and analytical applications. Acetaminophen metabolite 3-hydroxy-acetaminophen is a non-toxic metabolite and antioxidant of acetaminophen (HY-66005) with free radical scavenging activity. Acetaminophen metabolite 3-hydroxy-acetaminophen can reduce oxidative damage by exerting electron donation ability and antioxidant activity through phenolic hydroxyl groups. 3-hydroxy-acetaminophen can be used to study the toxicity mechanism and drug metabolism of acetaminophen.
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rel-cis-Pinic acid
0 ImagesCat. No.: HY-W588220CAS No.: 61774-58-1rel-cis-Pinic acid is one of the most important oxidation products of α-pinene - a key monoterpene compound in biogenic emission processes.
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4-Hydroxyphenylbutazone-d9
0 ImagesCat. No.: HY-W740777CAS No.: 1246819-23-74-Hydroxyphenylbutazone-d9 is the deuterium labeled 4-Hydroxyphenylbutazone (HY-139199). 4-Hydroxyphenylbutazone is a metabolite of Phenylbutazone. Phenylbutazone, a nonsteroidal anti-inflammatory agent (NSAID), is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS).
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ERG-IN-5
0 ImagesCat. No.: HY-180919CAS No.: 3047675-62-4ERG-IN-5 (Compound M1) is a metabolite of ERG-IN-4 (HY-180918), and it is a hERG potassium channel inhibitor with an IC50 of 1.5 μM. ERG-IN-5 is cytotoxic to MTAPdel HCT116 and its CC50 is 28 nM. ERG-IN-5 can be used for the study of colon cancer.
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(R)-3-Hydroxy Midostaurin
0 ImagesCat. No.: HY-108263BCAS No.: 155848-20-7Synonyms: (R)-CGP52421(R)-3-Hydroxy Midostaurin ((R)-CGP52421) is a potent kinases inhibitor. (R)-3-Hydroxy Midostaurin is a major metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (R)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML).
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Desmethylmirtazapine (Standard)
0 ImagesCat. No.: HY-119223RCAS No.: 61337-68-6Synonyms: Normirtazapine (Standard)Desmethylmirtazapine (Standard) is the analytical standard of Desmethylmirtazapine. This product is intended for research and analytical applications. Desmethylmirtazapine is an active metabolite of Mirtazapine that has antidepressant effects.
