Glycosidase

Related Products

Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases^[1]^[2].

References:

[1]. Wang X, et al. Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review. Front Microbiol. 2022 Nov 17;13:1050869.

[2]. Ohtsubo K, et al. Glycosylation in cellular mechanisms of health and disease. Cell. 2006 Sep 8;126(5):855-67. [Content Brief]

Glycosidase Related Products (605)
Antibodies (3)

By Effects:	Inhibitors (419) Degraders (2) Controls (4) Substrates (18) Ligands (3) Antagonist (1) Activators (18) Modulators (7) Chemical (1) Inducers (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N13173

α-Glucosidase-IN-70	Inhibitor
α-Glucosidase-IN-70 (compound 9) is an α-glucosidase inhibitor (IC₅₀=31.1 μM) isolated from the traditional Chinese herbal medicine Swertia mussotii. α-Glucosidase-IN-70 can be used in the research of diabetes.

HY-B0025R

Voglibose (Standard)	Inhibitor
Voglibose (Standard) is the analytical standard of Voglibose. This product is intended for research and analytical applications. Voglibose is an orally active alpha-glucosidase inhibitor that prevents the development of colorectal precancerous lesions induced by obesity and diabetes. Voglibose reduces oxidative stress in an inflammatory environment and inhibits the insulin-like growth factor/insulin-like growth factor-1 receptor (IGF/IGF-1R) functional axis[1].

HY-E71305B

β-Glucosidase 1A, Clostridium cellulovorans
β-Glucosidase 1A, Clostridium cellulovorans (EC 3.2.1.21) is a glucosidase enzyme that acts upon β1->4 bonds linking two glucose or glucose-substituted molecules (i.e., the disaccharide cellobiose) . β-Glucosidase is one of the cellulases, enzymes involved in the decomposition of cellulose and related polysaccharides; more specifically, an exocellulase with specificity for a variety of beta-D-glycoside substrates. It catalyzes the hydrolysis of terminal non-reducing residues in beta-D-glucosides with release of glucose.

HY-E71305D

β-Glucosidase 1A, Pectobacterium carotovorum
β-Glucosidase 1A, Bacillus halodurans (EC 3.2.1.21) is a glucosidase enzyme that acts upon β1->4 bonds linking two glucose or glucose-substituted molecules (i.e., the disaccharide cellobiose) . β-Glucosidase is one of the cellulases, enzymes involved in the decomposition of cellulose and related polysaccharides; more specifically, an exocellulase with specificity for a variety of beta-D-glycoside substrates. It catalyzes the hydrolysis of terminal non-reducing residues in beta-D-glucosides with release of glucose.

HY-E70889C

β-Xylosidase, Bacillus subtilis
β-Xylosidase, Bacillus subtilis (EC 3.2.1.37) can release reducing sugars from birch xylan and catalyze the hydrolysis of 4-methylumbelliferone-β-D-cellobiose and 4-methylumbelliferone-β-D-glucopyranoside. β-Xylosidase does not possess endoxylanase, arabinoxylanase, or β-glucanase activity. β-Xylosidase undergoes post-translational glycosylation modification.

HY-181253

α-Glucosidase-IN-111	Inhibitor
α-Glucosidase-IN-111 (Compound 5d) is an α-glucosidase (α-Glucosidase) inhibitor with a IC₅₀ of 34.99 μg/mL. α-Glucosidase-IN-111 effectively scavenges DPPH free radicals and ABTS free radicals, with IC₅₀ values of 5.33 and 5.84 μg/mL, respectively. α-Glucosidase-IN-111 can be used in the research of type 2 diabetes.

HY-111327

Valibose	Inhibitor
Valibose is analpha-glucosidaseinhibitor, and ameliorates the metabolic disorder of glucose and lipids and the nephropathy in Streptozotocin (HY-13753)-induced diabetic rats.

HY-129131

Chrysin 6-C-arabinoside 8-C-glucoside	Inhibitor	99.90%
Chrysin 6-C-arabinoside 8-C-glucoside is a α±-glucosidase inhibitors which are widely used in the study for type 2 diabetes.

HY-172758

α-Glucosidase-IN-89	Inhibitor
α-Glucosidase-IN-89 (8g) is α-glucosidase inhibitor, with an IC₅₀ of 0.5 μM and a K_i of 0.46 µM.

HY-105291

CKD-711	Inhibitor
CKD-711 is an orally active aminooligosaccharide α-glucosidase inhibitor with an IC₅₀ of 78 μg/mL. CKD-711 also inhibits porcine intestinal maltase and sucrose with IC₅₀ values of 2.5 and 0.5 μg/mL. CKD-711 shows selective antibacterial activity against Comamonas terrigena. CKD-711 can be used for the researches of infection and metabolic disease, such as diabetes.

HY-181707

RTA ligand 1	Ligand
RTA ligand 1 is a ricin toxin A chain (RTA) ligand and can be used for the synthesis of PROTACs, such as PROTAC RTA Degrader-1 (HY-181705).

HY-183586

G721-0377	Modulator
G721-0377 is a CHI3L1 modulator with a human K_d value of 45 μM. G721-0377 binds to CHI3L1 and modulates downstream signaling pathways. G721-0377 suppresses CHI3L1-induced NF-κB activation, decreases secretion of CHI3L1 and IL-6. G721-0377 can be used for the research of Alzheimer's disease.

HY-N0346AR

(E)-Ethyl p-methoxycinnamate (Standard)	Inhibitor
(E)-Ethyl p-methoxycinnamate (Standard) is the analytical standard of (E)-Ethyl p-methoxycinnamate. This product is intended for research and analytical applications. (E)-Ethyl p-methoxycinnamate is a natural product found in Kaempferia galangal with anti-inflammatory, anti-neoplastic and anti-microbial effects. (E)-Ethyl p-methoxycinnamate inhibits COX-1 and COX-2 in vitro with IC₅₀s of 1.12 and 0.83 μM, respectively.

HY-149332

α-Glucosidase-IN-26	Inhibitor
α-Glucosidase-IN-26 (Compound 7i) is an α-glucosidase inhibitor (IC₅₀=4.63 µM). α-Glucosidase-IN-26 can be used in the study of type 2 diabetes mellitus (T2DM).

HY-182712

HPSE-IN-2	Inhibitor
HPSE-IN-2 is a heparanase (HPSE) inhibitor with an IC₅₀ of 0.27 µM. HPSE-IN-2 reduces lung metastasis in mouse models. HPSE-IN-2 can be used for the research of melanoma.

HY-169255

sPLA2 inhibitor 3	Inhibitor
sPLA2 inhibitor 3 (Compound 6c) is a potent α-glucosidase inhibitor (IC₅₀ = 0.0953 µM). sPLA2 inhibitor 3 can be used for the research of diabetes.

HY-E71316A

β-Mannanase 26A, Celvibrio japonicus
β-Mannanase 26A, Celvibrio japonicas is an enzyme with system name 4-beta-D-mannan mannanohydrolase. This enzyme catalyses the following chemical reaction: Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.

HY-152158

α-Glucosidase-IN-22	Inhibitor	99.13%
α-Glucosidase-IN-22 (Compound 7i) is a α-glucosidase inhibitor with an IC₅₀ value of 0.64 μM. α-Glucosidase-IN-22 can be used for the research of type 2 diabetes.

HY-162637

CTL26	Inhibitor
CTL26 is a potent and orally active α-glucosidase inhibitor with an IC₅₀ value of 2.81 µM. CTL26 shows anti-diabetic efficacy.

HY-131570

JZ-4109	Modulator
JZ-4109 is a β-Glucocerebrosidase (GCase) modulator with an IC₅₀ of 8 nM for wild-type recombinant GCase. JZ-4109 binds to an allosteric site at the GCase dimer interface, stabilizes wild-type and GCase^N370S mutant GCase, induces GCase dimerization. JZ-4109 increases GCase protein abundance. JZ-4109 can be used for the research of Parkinson's diseas.

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Glycosidase

Glycosidase

Glycosidase Related Products (605)

Antibodies (3)

Glycosidase Related Products (605):