IGF-1R
Insulin-like growth factor-1 receptor
IGF-1R (Insulin-like growth factor 1 receptor), a receptor tyrosine kinase, is activated upon binding to the ligands IGF-1 or IGF-2 leading to cell growth, survival and migration of both normal and cancerous cells.
IGF-1R can initiate the activation of the PI3K/AKT/mTOR signaling and Ras/Raf/MEK/MAPK pathways resulting in the activation of multiple transcription factors such as ELK-1, CREB and AP-1 to modulate cell proliferation, survival, differentiation, motility, invasion and angiogenesis. IGF-1R overexpression or increased IGF-1R kinase activity is associated with a broad range of human cancers and therefore the IGF-1R is widely considered as a very promising target for cancer treatment.
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IGF-1R Inhibitors
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IGF-1R Agonists
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IGF-1R Antagonists
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IGF-1R Activators
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IGF-1R Modulators
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IGF-1R Degrader
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IGF-1R Control
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IGF-I R/CD221 Proteins
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IGF-1R Related Products (113)
Related Products (113)
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Recombinant Proteins (12)
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Antibodies (13)
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AZ7550 Mesylate (Standard)
0 ImagesSynonyms: AZ7550 trimesylate salt (Standard)AZ7550 Mesylate (Standard) is the analytical standard of AZ7550 Mesylate. This product is intended for research and analytical applications. AZ7550 Mesylate is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.
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TAK-778
0 ImagesCat. No.: HY-100167CAS No.: 180185-61-9TAK-778 is a derivative of ipriflavone and has been shown to induce bone growth in in vitro and in vivo models.
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IGF-1R-IN-6
0 ImagesCat. No.: HY-189085CAS No.: 1186659-59-5
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IGFBP-3 peptide
0 ImagesCat. No.: HY-P10403CAS No.: 319426-26-1
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KW-2450 tosylate
0 ImagesCat. No.: HY-19565CAS No.: 1360433-93-7KW-2450 tosylate is an orally active Aurora A and B kinases, IGF-1R, and IR tyrosine kinases inhibitor. KW-2450 tosylate induces Apoptosis. KW-2450 tosylate also exhibits anticancer activity against triple-negative breast cancer.
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Sorbic acid-13C2
0 ImagesCat. No.: HY-W747751Sorbic acid-13C2 is the 13C-labeled Sorbic acid (HY-N0626). Sorbic acid is an effective, safe, and non-toxic food preservative. It can effectively inhibit most molds, yeasts, and certain bacteria. Sorbic acid is orally active and can enhance the growth performance of economically important animals (Duroc × Landrace × Yorkshire piglets) by activating the insulin-like growth factor system (IGF), and it can also lead to lipid accumulation by disrupting lipid clearance pathways.
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Ginsenoside Rg5 (Standard)
0 ImagesCat. No.: HY-N0908RCAS No.: 186763-78-0Ginsenoside Rg5 (Standard) is the analytical standard of Ginsenoside Rg5. This product is intended for research and analytical applications. Ginsenoside Rg5 is the main component of Red ginseng and IGF-1R agonist. Ginsenoside Rg5 compets for the binding site of IGF-1R and blocks the binding of IGF-1 to IGF-1R (IC50 about 90 nM). Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65.
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Picropodophyllin-d3
0 ImagesCat. No.: HY-15494SCAS No.: 1454782-81-0Synonyms: AXL1717-d3; Picropodophyllotoxin-d3; PPP-d3Picropodophyllin-d3 (AXL1717-d3; Picropodophyllotoxin-d3; PPP-d3) is the deuterium labeled Picropodophyllin (HY-15494). Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM.
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IGF-I (24-41) TFA
0 ImagesCat. No.: HY-P1777ASynonyms: Insulin-like Growth Factor I (24-41) TFAIGF-I (24-41) (Insulin-like Growth Factor I (24-41)) TFA is amino acids 24 to 41 fragment of IGF-I. IGF-I TFA, a 70 aa polypeptide hormone, is a trophic factor for both neurons and glial cells. IGF-I TFA is partly responsible for systemic growth hormone (GH) activities. IGF-I TFA has anabolic, antioxidant, anti-inflammatory and cytoprotective actions. IGF-I (24-41) TFA regulates somatic growth and behavioral development.
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GPVGPS
0 ImagesCat. No.: HY-P11890CAS No.: 1154403-54-9GPVGPS is a low-molecular-weight fish collagen peptide. GPVGPS upregulates the expression of vascular endothelial growth factor (VEGF), PCNA, hepatocyte growth factor, epidermal growth factor (EGF) , and insulin-like growth factor 1 (IGF-1), and downregulates the expression of negative regulatory proteins associated with hair health. GPVGPS inhibits MMP-1, MMP-2, and MMP-9, increases skin water content, reduces wrinkles, and improves oxidative stress status and pro-inflammatory cytokine levels. GPVGPS can be used in studies related to hair loss and UVB-induced skin photoaging.
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GSK2163632A
0 ImagesCat. No.: HY-118046CAS No.: 1123163-20-1GSK2163632A is a selective G protein-coupled receptor kinase (GRK) inhibitor that can be used as a probe for studying heart failure and Parkinson's disease. GSK2163632A potently inhibits GRK1 and GRK5, and also inhibits Rho-associated coiled-coil kinase (ROCK) and insulin-like growth factor receptor IGF-1R. GSK2163632A binds to GRK2 in a manner similar to Paroxetine (HY-122272).
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Cibrigirsen sodium
0 ImagesCat. No.: HY-177622ACibrigirsen sodium is an antisense oligonucleotide targeted to the insulin-like growth factor I receptor(IGF-1R).
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Cibrigirsen sodium scrambled negative control
0 ImagesCat. No.: HY-177622BCibrigirsen sodium scrambled negative control is the sequence scrambled negative control of Cibrigirsen sodium.
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IGF-1R modulator 1
0 ImagesCat. No.: HY-402309CAS No.: 2375424-89-6IGF-1R modulator 1 (Example 5) is an IGF-1R modulator, with EC50s of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), 0.39 μM (TrkB). IGF-1R modulator 1 can be used for research of diseases characterised by impaired signalling of neurotrophins and/or other trophic factors, such as Alzheimer's disease.
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INSR Recombinant Human Active Protein Kinase
0 ImagesCat. No.: HY-E70730The whole IGF axis constitutes an interactive network composed of the peptide-ligands IGF1, IGF2 and insulin, and the receptors IGF1R, IGF2R and insulin receptor (INSR) as IGF binding proteins (IGFBPs). The INSR itself appears in two isoforms, INSRA and INSRB differing in 12 amino acids encoded by exon 11. INSR Recombinant Human Active Protein Kinase is a recombinant INSR protein that can be used to study INSR-related functions.
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Cibrigirsen
0 ImagesCat. No.: HY-177622CAS No.: 160614-28-8Cibrigirsen is an antisense oligonucleotide targeted to the insulin-like growth factor I receptor(IGF-1R).
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Cyclo(Gly-Pro)
0 ImagesCat. No.: HY-P11431CAS No.: 97011-16-0Cyclo(Gly-Pro) is a cyclic dipeptide. Cyclo(Gly-Pro) can be derived from the Nterminus of the IGF-1. Cyclo(Gly-Pro) attenuates nociceptive behaviour and inflammatory response in mice.
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AZ-5104 (GMP)
0 ImagesCat. No.: HY-B0793GCAS No.: 1421373-98-9AZ-5104 GMP is a GMP-grade form of AZ-5104 (HY-B0793). AZ-5104 is an orally active RORγ receptor-active compound, and also a circulating metabolite of AZD9291. AZ-5104 inhibits sensitizing EGFR mutants, EGFRT790M drug-resistant EGFR mutants and wild-type EGFR, while showing no activity against the IGF-1R family. AZ-5104 can be used in the research of non-small cell lung cancer.
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IGF-I (30-41) TFA
0 ImagesCat. No.: HY-P1773ASynonyms: Insulin-like Growth Factor I (30-41) TFAIGF-I (30-41) (TFA) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I). IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions).
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PROTAC ALK degrader-4
0 ImagesCat. No.: HY-179732PROTAC ALK degrader-4 is a ALK PROTAC degrader with a DC50 of 445.25 nM. PROTAC ALK degrader-4 induces concentration- and time-dependent degradation of EML4-ALK, as well as concentration-dependent degradation of ALKF1174L. PROTAC ALK degrader-4 downregulates 390 proteins in NCI-H3122 cells, including the targets of ceritinib (ALK, IGF-1R) and downstream molecules ERK1/2 and STAT3. PROTAC ALK degrader-4 exerts antiproliferative activity in ALK-positive cancer cells. ALK degrader-4 can be used in studies related to lung adenocarcinoma.
