IL-4
Interleukin-4 (IL-4) is a critical Th2 cytokine that regulates immune responses by promoting differentiation of naive CD4+ T cells into Th2 cells[1]. Mechanistically, IL-4 activates the JAK-STAT6 signaling pathway, leading to transcriptional induction of genes involved in humoral immunity, including IgE class switching in B cells[1]. In disease models, IL-4 contributes to the pathogenesis of allergic inflammation and asthma by inducing eosinophilia, mucus hyperproduction, and alternatively activated macrophages[1]. Compared with related isoforms such as IL-13, IL-4 exhibits unique receptor engagement, preferentially signaling through IL-4Rα paired with the common gamma chain, which defines distinct cellular responses[1]. IL-4 agonists and inhibitors have been applied in experimental research to modulate Th2-skewed immune responses, enabling the study of allergic airway inflammation and potential therapeutic interventions[1]. Experimental blockade of IL-4 reduces IgE production and airway hyperreactivity, confirming its central role in type 2 immunity and providing a framework for targeted immunomodulation in preclinical models[1]. Therefore, IL-4 serves as both a mechanistic marker and a modifiable factor in studies of cytokine-driven inflammation.
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IL-4 Related Products (89)
Related Products (89)
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Recombinant Proteins (26)
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Antibodies (1)
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C6 D-Threo Ceramide (d18:1/6:0)
0 ImagesCat. No.: HY-116585CAS No.: 189894-79-9C6 D-Threo Ceramide (d18:1/6:0) is a bioactive sphingolipid and cell-permeable analog of ceramides. C6 D-Threo Ceramide (d18:1/6:0) enhances IL-4 production induced by Phorbol 12-myristate 13-acetate (HY-18739) in EL4 T cells.
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Olcorolimus
0 ImagesCat. No.: HY-106979CAS No.: 186752-78-3Synonyms: SAR-943Olcorolimus (SAR-943) is a Rapamycin (HY-10219) derivative. Olcorolimus can reduce IL-4, IL-5, eosinophil, neutrophil, lymphocyte, cellular fibronectin; lung epithelial cell proliferation and mucus hypersecretory phenotype in Ovalbumin (HY-W250978)-sensitized BALB/c mice. Olcorolimus can be used for the researches of inflammation and immunology, such as asthma.
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Epinastine-13C,d3 hydrobromide
0 ImagesCat. No.: HY-B0640SSynonyms: WAL801-13C,d3 hydrobromideEpinastine-13C,d3 (hydrobromide) is the 13C- and deuterium labeled Epinastine. Epinastine (WAL801) is an antihistamine and mast cell stabilizer. Epinastine is a potent, selective and orally-active histamine H1 receptor antagonist. Epinastine also inhibits IL-8 release and has an antiallergic action.
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Glycolipid C34
0 ImagesCat. No.: HY-186103CAS No.: 1204401-08-0Glycolipid C34, α-GalCer (HY-102022) analog, is a CD1d-binding glycolipid antinfection agent. Glycolipid C34 mediates invariant natural killer T cell activation and increases the secretion of IFN-γ and IL-4. Glycolipid C34 promotes clearance of bacterial infections in murine models and enhances protective immunity against viral infections. Glycolipid C34 can be used for the research of bacterial infection, viral infection.
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IL-4-IN-2
0 ImagesCat. No.: HY-187160CAS No.: 3104023-24-4IL-4-IN-2 (Compound 14/analog 14) is a selective IL-4 inhibitor. IL-4-IN-2 binds to soluble IL-4 and inhibits IL-4-mediated signal transduction. IL-4-IN-2 suppresses STAT-6 phosphorylation induced by IL-13 and IL-4 in monocytes and B lymphocytes. IL-4-IN-2 is applicable to the research of allergic inflammation, cancer, autoimmune diseases, asthma and arthritis.
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RV-6153
0 ImagesCat. No.: HY-124459CAS No.: 1628139-03-6RV-6153 is a potent and selective dual inhibitor of PI3Kδ and PI3Kγ, with IC50 values of 2.5 nM and 28 nM, respectively. RV-6153 dually inhibits PI3Kδ and PI3Kγ, blocking Akt phosphorylation, thereby inhibiting ROS production and cytokine release at the cellular level, and reducing neutrophil and macrophage accumulation in the airways in vivo. RV-6153 can be used in research on chronic obstructive pulmonary disease, asthma, and other inflammatory diseases.
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Aloin (mixture of A&B) (Standard)
0 ImagesAloin (mixture of A&B) (Standard) is the analytical standard of Aloin (mixture of A&B) (HY-N6013). This product is intended for research and analytical applications. Aloin (mixture of A&B) is an orally active anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) mitigates airway impairment and exerts neuroprotective, anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral and antitumor effects. Aloin (mixture of A&B) inhibits Clostridium histolyticum collagenase, granulocyte matrix metalloproteinases and human 20S proteasome. Aloin (mixture of A&B) upregulates the Nrf2/HO-1 pathway, suppresses the TGF-β/Smad2/3 pathway. Aloin (mixture of A&B) reduces IL-4/IL-5/IL-13 levels, and reverses oxidative stress markers (MDA, SOD, GSH). Aloin (mixture of A&B) can be used for research on chronic ulcers, burns, wounds, inflammatory and degenerative disorders, asthma and neuroblastoma.
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RPR-106541
0 ImagesCat. No.: HY-19218CAS No.: 159001-35-1RPR-106541 is a 17-thiosteroid. RPR 106541 has potent glucocorticosteroid activity. RPR 106541 also has demonstrable effects on carbohydrate and lipid metabolism.
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(E)-Methyl 4-coumarate (Standard)
0 ImagesSynonyms: Methyl trans-p-coumarate (Standard)(E)-Methyl 4-coumarate (Standard) is the analytical standard of (E)-Methyl 4-coumarate (HY-N2492). This product is intended for research and analytical applications. (E)-Methyl 4-coumarate (Methyl 4-hydroxycinnamate) is a phenolic compound and derivative of Cinnamic acid (HY-N0610A). (E)-Methyl 4-coumarate can be found in several plants, such as the leaves of Allium cepa and Morinda citrifolia L. (E)-Methyl 4-coumarate, when combined with Carnosic acid (HY-N0644), induces Apoptosis. (E)-Methyl 4-coumarate inhibits GSK3β activity and modulates inflammatory cytokine levels (increasing IL-10 and decreasing IL-4). (E)-Methyl 4-coumarate combined with Carnosic acid exhibits anticancer effects against acute myeloid leukemia. (E)-Methyl 4-coumarate ameliorates Plasmodium berghei NK65 infection.
