Microtubule/Tubulin
Microtubules are a component of the cytoskeleton, found throughout the cytoplasm. These tubular polymers of tubulin can grow as long as 50 micrometres, with an average length of 25 µm, and are highly dynamic. The outer diameter of a microtubule is about 24 nm while the inner diameter is about 12 nm. Microtubules are found in eukaryotic cells and are formed by the polymerization of a dimer of two globular proteins, alpha and beta tubulin. Tubulin is one of several members of a small family of globular proteins. The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family which is present only in kinetoplastid protozoa. The most common members of the tubulin family are α-tubulin and β-tubulin, the proteins that make up microtubules. Microtubules are very important in a number of cellular processes. They are involved in maintaining the structure of the cell.
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Microtubule/Tubulin Inhibitors
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Microtubule/Tubulin Modulators
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Microtubule/Tubulin Controls
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Microtubule/Tubulin Ligands
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Microtubule/Tubulin Related Products (1000)
Related Products (1000)
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Antibodies (69)
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TH588 hydrochloride
0 ImagesCat. No.: HY-12814ACAS No.: 1640282-30-9TH588 hydrochloride is a highly selective human MTH1 inhibitor (IC50=5 nM) with additional microtubule-targeting properties. TH588 hydrochloride interferes with mitotic progression, induces genomic 8-oxodG formation, DNA damage and cell cycle arrest, and exhibits significant cytotoxicity. Combined with phenethyl isothiocyanate, TH588 hydrochloride enhances ROS-mediated effects and effectively inhibits the growth of visceral metastases of malignant melanoma in mice. TH588 hydrochloride is widely applicable to research related to cancers, pancreatic cancer, leukemia, lymphoma, malignant melanoma and lung cancer.
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7-xylosyltaxol
0 ImagesCat. No.: HY-77574CAS No.: 90332-66-4Synonyms: 7-Xylosylpaclitaxel; Taxol-7-xyloside7-Xylosyltaxol (Taxol-7-xyloside) is a derivative of Paclitaxel (HY-B0015) found in the bark of Taxus wallichiana var. mairei. 7-Xylosyltaxol inhibits the growth of various cancer cells. 7-Xylosyltaxol can be used in cancer-related research.
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2-Methylthiophenothiazine
0 Images2-Methylthiophenothiazine (compound 17) is a precursor of tubulin inhibitor with potential anticancer activity and can inhibit tubulin aggregation.
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Tirbanibulin Mesylate (Standard)
0 ImagesSynonyms: KX2-391 Mesylate (Standard); KX01 Mesylate (Standard)Tirbanibulin (Mesylate) (Standard) is the analytical standard of Tirbanibulin (Mesylate). This product is intended for research and analytical applications. Tirbanibulin Mesylate (KX2-391 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines.
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T900607
0 ImagesCat. No.: HY-117841CAS No.: 261944-52-9T900607 is an anti-tumor agent and targets microtubule polymerization.
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Ixabepilone (Standard)
0 ImagesCat. No.: HY-10222RCAS No.: 219989-84-1Synonyms: BMS-247550 (Standard); Aza-epothilone B (Standard)Ixabepilone (Standard) is the analytical standard of Ixabepilone. This product is intended for research and analytical applications. Ixabepilone (BMS-247550) is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis.
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Tubulin polymerization-IN-74
0 ImagesTubulin polymerization-IN-74 (compound 11) is a Tubulin polymerization inhibitor, with IC50 of 15 μM. Tubulin polymerization-IN-74 can be used in anticancer research.
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Microtubule-IN-10
0 ImagesCat. No.: HY-165283CAS No.: 1027308-36-6Microtubule-IN-10 (compound 9) is an isocoumarin-type microtubule assembly inhibitor. Microtubule-IN-10 exerts an anti-tumor effect by inducing mitotic arrest and apoptosis in multiple myeloma cells. Microtubule-IN-10 can be used for the research of multiple myeloma.
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SSE15206 (Standard)
0 ImagesCat. No.: HY-111425RCAS No.: 1370046-40-4SSE15206 (Standard) is the analytical standard of SSE15206 (HY-111425). This product is intended for research and analytical applications. SSE15206 is a microtubule polymerization inhibitor (GI50 = 197 nM in HCT116 cells) that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells.
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Ethalfluralin
0 ImagesCat. No.: HY-W714214CAS No.: 55283-68-6Ethalfluralin is a dinitroaniline herbicide and microtubule inhibitor. Ethalfluralin blocks nuclear division and cytokinesis of parasites by inhibiting intranuclear spindle formation. Ethalfluralin activates the phosphorylation levels of NF-κB and P38 MAPK, inhibits the PI3K/AKT signaling pathway, impairs mitochondrial function, and induces apoptosis, endoplasmic reticulum stress, autophagy, and ROS production. Ethalfluralin is applicable to research related to toxoplasmosis.
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Tasidotin hydrochloride
0 ImagesCat. No.: HY-13760CAS No.: 623174-20-9Synonyms: ILX651Tasidotin hydrochloride is a peptide analog of the antimitotic depsipeptide dolastatin 15, as an inhibitor of microtubule assembly and microtubule dynamics.
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IG-105
0 ImagesCat. No.: HY-111175CAS No.: 905978-63-4IG-105 is an orally active and potent tubulin inhibitor that competitively inhibits [3H] colchicine binding to tubulin with an IC50 of 0.6 μM and inhibits tubulin polymerization with an IC50 of 3 μM. IG-105 inhibits microtubule polymerization by binding to the colchicine pocket of tubulin, induces G2-M phase arrest, and subsequently activates the caspase cascade through Bcl-2 inactivation and p53 upregulation, inducing apoptosis. IG-105 effectively overcomes multidrug resistance as a non-Pgp substrate. IG-105 can be used for research on leukemia, breast cancer, liver cancer, prostate cancer, lung cancer, melanoma, pancreatic cancer, and colon cancer.
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Fluchloralin
0 ImagesCat. No.: HY-W714212CAS No.: 33245-39-5Fluchloralin is a dinitroaniline herbicide that effectively controls annual gramineous and broadleaf weeds primarily by inhibiting tubulin synthesis and cell division. Fluchloralin exhibits cytotoxicity and genotoxicity, and promotes cell apoptosis by activating apoptotic signaling proteins, forming DNA ladder bands, inducing cell shrinkage and nuclear fragmentation.
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AB8939
0 ImagesCat. No.: HY-171183CAS No.: 1974336-09-8AB8939 is an effective small moleculeMicrotubule/Tubulin polymerization inhibitor with anti-tumor activity (it inhibits tumor cell proliferation with an IC50 of less than 10 nM). AB8939 can effectively evade resistance mechanisms mediated by things like P-glycoprotein and myeloperoxidase. AB8939 can induce G2/M phase cell cycle arrest and apoptosis in cells.
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Oryzalin (Standard)
0 ImagesOryzalin (Standard) is the analytical standard of Oryzalin (HY-147092). This product is intended for research and analytical applications. Oryzalin is a dinitroaniline herbicide with antimitotic and antileishmanial activities. Oryzalin can bind to plant tubulin, inhibit the polymerization of microtubules in plant cells, and affect chromosome migration. Oryzalin can also be used to induce chromosome doubling.
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Bifidenone
0 ImagesCat. No.: HY-119548CAS No.: 2078008-57-6Bifidenone is a tubulin polymerization inhibitor that exhibits antiproliferative activity against a range of human cancer cell lines.
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Vindoline (Standard)
0 ImagesVindoline (Standard) is an analytical standard of Vindoline (HY-N0687). This product is intended for research and analytical applications. Vindoline is an orally active vinca alkaloid. Vindoline can be extracted from the leaves of Catharanthus roseus. Vindoline has a weak inhibitory effect on the self-assembly of tubulin. Vindoline alleviates Apoptosis, inhibits p-p65 and p-ERK. Vindoline improves diabetes, bone loss, osteoarthritis, and kidney damage.
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CHM-1 (Standard)
0 ImagesCat. No.: HY-103257RCAS No.: 154554-41-3Synonyms: NSC656158 (Standard)CHM-1 (Standard) is the analytical standard of CHM-1 (HY-103257). This product is intended for research and analytical applications. CHM-1, a microtubule-destabilizing agent, inhibits tubulin polymerization. CHM-1 is a potent and selective antimitotic antitumor activity against human hepatocellular carcinoma. CHM-1 induces growth inhibition and apoptosis via G2-M phase arrest in human hepatocellular carcinoma cells by activation of Cdc2 kinase activity.
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3,4',5-Trismethoxybenzophenone
0 ImagesCat. No.: HY-120890CAS No.: 94709-12-33,4',5-Trismethoxybenzophenone (compound 16a) is a potent tubulin assembly inhibitor with an IC50 value of 2.6 µM.
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Cabazitaxel (Standard)
0 ImagesSynonyms: XRP6258 (Standard); RPR-116258A (Standard); taxoid XRP6258 (Standard)Cabazitaxel (Standard) is the analytical standard of Cabazitaxel. This product is intended for research and analytical applications. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.
