PPAR
Peroxisome proliferator-activated receptors
PPARs (Peroxisome proliferator-activated receptors) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, PPARγ, and PPARβ/δ. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms. All PPARs heterodimerize with the retinoid X receptor (RXR) and bind to specific regions on the DNA of target genes. Activation of PPAR-α reduces triglyceride level and is involved in regulation of energy homeostasis. Activation of PPAR-γ enhances glucose metabolism, whereas activation of PPAR-β/δ enhances fatty acids metabolism.
PPAR Isoform Specific Products
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PPAR Inhibitors
(106)
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PPAR Agonists
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PPAR Antagonists
(31)
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PPAR Activators
(171)
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PPAR Modulators
(43)
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PPAR Inducers
(6)
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PPAR Controls
(3)
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PPAR Ligands
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Peroxisome Proliferator-activated Receptor Proteins
(11)
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PPAR alpha Proteins
(2)
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PPAR gamma Proteins
(7)
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PPAR-delta Proteins
(2)
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PPAR Related Products (748)
Related Products (748)
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Recombinant Proteins (11)
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Antibodies (4)
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PPAR Isoform Comparison
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Perfluoropentanoic acid (Standard)
0 ImagesPerfluoropentanoic acid (Standard) (PFPeA (Standard)) is the analytical standard of Perfluoropentanoic acid (HY-21193). This product is intended for research and analytical applications. Perfluoropentanoic acid (PFPeA), a short-chain perfluorinated compound, serves as an important indicator of perfluorinated compound pollution in ecosystems. Perfluoropentanoic acid exhibits certain toxicity to mice.
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PPARα/γ agonist 5
0 ImagesCat. No.: HY-167950CAS No.: 849150-59-0PPARα/γ agonist 5 is a dual PPARα/γ agonist with significant biological activity exhibited at low concentrations. The EC50 of PPARα/γ agonist 5 are 0.358μM and 1.21μM respectively, showing its potential in inhibiting type 2 diabetes and lipid metabolism disorders. PPARα/γ agonist 5 was selected for clinical development due to its high efficacy.
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Cefetecol hydrate
0 ImagesCat. No.: HY-159796CAS No.: 127182-67-6Synonyms: GR69153 hydrateCefetecol hydrate (GR69153 hydrate) is a semisynthetic β-lactam antibacterial agent and α-glucosidase inhibitor (yeast IC50 = 2.1 μM; Ki = 5.78 μM) that crosses the blood-brain barrier. Cefetecol hydrate reduces blood glucose levels in Streptozotocin-induced diabetic mice. Cefetecol hydrate decreases the mRNA expression of GSK-3, PPAR-γ, and UCP-3. Cefetecol hydrate induces bacterial cell filamentation and exhibits bactericidal activity against Gram-positive and Gram-negative bacteria. Cefetecol hydrate is used in the study of diabetes and bacterial infections.
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(E/Z)-Elafibranor
0 ImagesSynonyms: (E/Z)-GFT505(E/Z)-Elafibranor ((E/Z)-GFT505) is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively.
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Cefminox sodium (Standard)
0 ImagesSynonyms: MT-141 (Standard)Cefminox (sodium) (MT-141) (Standard) is the analytical standard of Cefminox (sodium). This product is intended for research and analytical applications. Cefminox sodium is a semisynthetic cephamycin, which exhibits antibacterial activity. Cefminox sodium is a broad-spectrum, bactericidal cephalosporin antibiotic. Cefminox sodium also acts as a dual agonist of prostacyclin receptor (IP) and PPARγ. Cefminox sodium upregulates cAMP production and PTEN expression and inhibits Akt/mTOR signaling. Cefminox sodium also prevents pulmonary arterial hypertension in rat model.
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Inolitazone
0 ImagesCat. No.: HY-14792CAS No.: 223132-37-4Synonyms: Efatutazone; CS-7017; RS5444
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Hexadecanamide (Standard)
0 ImagesSynonyms: Palmitamide (Standard)Hexadecanamide (Standard) is the analytical standard of Hexadecanamide. This product is intended for research and analytical applications. Hexadecanamide (Palmitamide) is a fatty acid amide that has orally active anti-allergic, antioxidant, and neuroprotective effects. Hexadecanamide exerts protective effects in Staphylococcus aureus- and SARA-induced mastitis. Hexadecanamide suppresses S. aureus-induced activation of the NF-κB pathway and improves blood-milk barrier integrity. Hexadecanamide activates PPARα. Hexadecanamide enhances sperm motility in vitro. Hexadecanamide can be studied in research for mastitis and asthenozoospermia.
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Farglitazar (Standard)
0 ImagesCat. No.: HY-105074RCAS No.: 196808-45-4Synonyms: GI262570 (Standard); GI262570X (Standard)Farglitazar (Standard) is the analytical standard of Farglitazar (HY-105074). This product is intended for research and analytical applications. Farglitazar is a PPARγ agonist that has significant therapeutic benefits such as glycemic control in type 2 diabetic patients.
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Aminophylline (Standard)
0 ImagesAminophylline (Standard) is the analytical standard of Aminophylline (HY-B0140). This product is intended for research and analytical applications. Aminophylline is a competitive phosphodiesterase 3/4 (PDE3/4) inhibitor. Aminophylline also acts as an adenosine receptor antagonist. Aminophylline elevates intracellular cAMP levels via competitive inhibition of PDE3 and PDE4, antagonizes adenosine A1 receptor (ADORA1), regulates intracellular calcium signaling and synaptic vesicle cycling, upregulates the PPAR signaling pathway, and downregulates glutamatergic synaptic pathways simultaneously. Aminophylline can be used in research related to major depressive disorder, epilepsy, asthma, and chronic obstructive pulmonary disease (COPD).
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Bezafibrate-13C6
0 ImagesCat. No.: HY-B0637S2Synonyms: BM15075-13C6
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17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid
0 ImagesCat. No.: HY-116115CAS No.: 1233715-33-7Synonyms: 17-Oxo-DPA; 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-DPA17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid (17-Oxo-DPA; 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-DPA) is an electrophilic oxo-derivative (EFOX) of the docosahexaenoic acid (DHA) (HY-B2167). 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is generated during inflammation by COX-2-catalyzed mechanism in activated macrophages. 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid acts as an agonist for PPARγ and a modulator for NF-κB signaling pathway, inhibits the production of pro-inflammatory cytokines and nitric oxide, and exhibits anti-inflammatory efficacy.
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5-Aminosalicylic acid-d7
0 ImagesCat. No.: HY-15027S4Synonyms: 5-ASA-d7; Mesalamie-d7; Mesalazie-d75-Aminosalicylic acid-d7 (5-ASA-d7; Mesalamie-d7; Mesalazie-d7) is deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).
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Elafibranor (Standard)
0 ImagesSynonyms: GFT505 (Standard)Elafibranor (Standard) is the analytical standard of Elafibranor. This product is intended for research and analytical applications. Elafibranor (GFT505) is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively. Elafibranor can be used for the study of primary biliary cholangitis.
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SC-236 (Standard)
0 ImagesCat. No.: HY-W010983RCAS No.: 170569-86-5SC-236 is an orally active COX-2 specific inhibitor (IC50 = 10 nM) and a PPARγ agonist. SC-236 suppresses activator protein-1 (AP-1) through c-Jun NH2-terminal kinase. SC-236 exerts anti-inflammatory effects by suppressing phosphorylation of ERK in a murine model.
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GW 2433
0 ImagesCat. No.: HY-120886CAS No.: 227941-61-9
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Bezafibrate (Standard)
0 ImagesSynonyms: BM15075 (Standard)Bezafibrate (Standard) is the analytical standard of Bezafibrate. This product is intended for research and analytical applications. Bezafibrate is an agonist of PPAR, with EC50s of 50 μM, 60 μM, 20 μM for human PPARα, PPARγ and PPARδ, and 90 μM, 55 μM, 110 μM for murine PPARα, PPARγ and PPARδ, respectively; Bezafibrate is used as an hypolipidemic agent.
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Cinoxate-d3
0 ImagesCat. No.: HY-107333S
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ZINC17167211
0 ImagesCat. No.: HY-117131CAS No.: 592539-21-4ZINC17167211 is a potent PPAR-α agonist (EC50=0.16 nM) that can be used in the study of diabetes, hyperlipidemia, and inflammatory diseases.
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Rivoglitazone (Standard)
0 ImagesCat. No.: HY-106181RCAS No.: 185428-18-6Synonyms: R-106056 (Standard)Rivoglitazone (Standard) is the analytical standard of Rivoglitazone (HY-106181). This product is intended for research and analytical applications. Rivoglitazone is a thiazolidinedione-derivative PPARγ agonist for the research of type 2 diabetes mellitus.
