Parasite
Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.
Parasite Isoform Specific Products
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Productos relacionados con Parasite (2553)
Productos relacionados con (2553)
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Related Compound Screening Libraries (1)
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Parasite Isoform Comparison
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PfCLK3-IN-1
0 ImagesReferencia número: HY-159963PfCLK3-IN-1 (Compound 4) is a covalent inhibitor for Plasmodium falciparum CLK3 (Pf CLK3) under alkaline conditions with an pEC50 of 7.1. PfCLK3-IN-1 reduces mature gametocytes in sexual stage parasites, and prevents transmission. PfCLK3-IN-1 inhibits P. falciparum Dd2-B2 clone with an IC50 of 239.5 nM.
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DXR-IN-4
0 ImagesReferencia número: HY-170783DXR-IN-4 (Compound 12a) is the inhibitor for 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR). DXR-IN-4 inhibits DXR in Plasmodium falciparum Pf DXR, Escherichia coli Ec DXR, and Mycobacterium tuberculosis Mt DXR with IC50s of 18, 4.9 and 89 nM, respectively. DXR-IN-4 exhibits antimalarial activity that inhibits P. falciparum strains 3D7 and Dd2 with IC50 of 11 μM and 12 μM.
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Antitoxoplasmal agent-1
0 ImagesReferencia número: HY-175246No. CAS: 294197-66-3Antitoxoplasmal agent-1 (Compound 4) is an antiparasitic agent. Antitoxoplasmal agent-1 has strong activity and selectivity against T. gondii, with an IC50 of 3.1 μM. Antitoxoplasmal agent-1 also has certain activity against L. major amastigotes, with an EC50 of 23.3 μM. Antitoxoplasmal agent-1 can be used in the research of parasite-related diseases.
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NPD-039
0 ImagesReferencia número: HY-167233No. CAS: 2229043-40-5NPD-039 is a selective tetrahydrophthalazinone-class TbrPDEB1 inhibitor with a Ki of 99 nM. NPD-039 occupies the hydrophobic clamp and the parasite-specific P-pocket of TbrPDEB1, and its glycinamide tail forms direct and water-mediated hydrogen bond interactions within the P-pocket. NPD-039 can be used in related research on Human African Trypanosomiasis.
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ent-Epanorin
0 ImagesReferencia número: HY-177539No. CAS: 3061155-25-4ent-Epanorin is an enantiomer of Epanorin (HY-N16418). ent-Epanorin has more potent antibacterial and antiparasitic activity against Bacillus subtilis (ATCC 6633), Staphylococcus aureus (ATCC 25923) and Giardiaduodenalis 713 compared to Epanorin.
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Antimalarial agent 59
0 ImagesReferencia número: HY-181658No. CAS: 3103602-12-3Antimalarial agent 59 is an antimalarial agent. Antimalarial agent 59 inhibits the growth of Chloroquine (HY-17589A)-resistant FcB1 strain of Plasmodium falciparum with an IC50 of 46 nM. Antimalarial agent 59 also shows cytotoxic activity against cancer cells. Antimalarial agent 59 can be used for the researches of malaria and ovarian cancer.
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PROTAC DHFR Degrader-1
0 ImagesReferencia número: HY-181813No. CAS: 3077918-47-6PROTAC DHFR Degrader-1 is a selective PROTAC degrader targeting Plasmodium falciparum DHFR-TS with a Ki of 2.01 nM. PROTAC DHFR Degrader-1 exhibits no inhibitory activity against human DHFR and suppresses the growth of Plasmodium falciparum. PROTAC DHFR Degrader-1 can be used for the research of Plasmodium falciparum and malaria.
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Crotamiton (Standard)
0 ImagesCrotamiton (Standard) is the analytical standard of Crotamiton. This product is intended for research and analytical applications. Crotamiton is a TRPV4 inhibitor. Crotamiton inhibits TRPV4 currents. Crotamiton inhibits TRPV4 selective agonist-induced pruritus-related behaviors in mice. Crotamiton inhibits Histamine- and Chloroquine-induced calcium influx via the H1R/TRPV1, MRGPRA3/TRPA1 pathways, and also suppresses calcium influx in primary mouse dorsal root ganglion neurons. Crotamiton is applicable to research related to pruritus, scabies, and non-scabietic pruritus.
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Dodecamethylpentasiloxane (Standard)
0 ImagesReferencia número: HY-W011035RNo. CAS: 141-63-9Dodecamethylpentasiloxane (Standard) is the analytical standard of Dodecamethylpentasiloxane. This product is intended for research and analytical applications. Dodecamethylpentasiloxane is a component of siloxanes and can be used as silicone oil. Dodecamethylpentasiloxane exhibits insecticidal activity against bed bug.
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HDAC-IN-82
0 ImagesReferencia número: HY-169922HDAC-IN-82 (Compound 18b) is a histone deacetylase (HDAC) inhibitor with selective antiplasmodial and anticancer activity. HDAC-IN-82 shows potent antiproliferative activity and caspase 3/7 activation in cancer cells. HDAC-IN-82 causes hyperacetylation of histone H3 and α-tubulin.
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PfPK6-IN-1
0 ImagesReferencia número: HY-175215No. CAS: 2417648-94-1PfPK6-IN-1 is a potent and selective PfPK6 inhibitor with an IC50 of 0.3 μM. PfPK6-IN-1 inhibits hemozoin formation, a Plasmodium-specific pathway with IC50 of 13 μM against β-hematin (βH). PfPK6-IN-1 exhibits rapid and broad-spectrum anti-malarial properties, being effective against both chloroquine-sensitive and resistant strains.PfPK6-IN-1 can be used for the study of antimalarial.
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GNF179 (Metabolite)
0 ImagesReferencia número: HY-15980No. CAS: 1310455-86-7GNF179 metabolite is the metabolite of GNF179, which is an optimized 8,8-dimethyl IP analog that exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability.
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4,5-Dihydropiperlonguminine
0 Images4,5-Dihydropiperlonguminine is a natural product that can be isolated from the seeds of Piper tuberculatum Jacq. (Piperaceae). 4,5-Dihydropiperlonguminine is a insecticide against velvetbean caterpillars.
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Sutidiazine
0 ImagesReferencia número: HY-148177No. CAS: 1821293-40-6Synonyms: ZY-19489; MMV 253; AZ13721412Sutidiazine (ZY-19489) is an orally active and antimalarial agent. Sutidiazine inhibits parasitemia-induced infection. Sutidiazine shows short half-lives (approximately 7 h) and an exposure effect.
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Imidocarb dipropionate (Standard)
0 ImagesImidocarb (dipropionate) (Standard) is the analytical standard of Imidocarb (dipropionate). This product is intended for research and analytical applications. Imidocarb dipropionate is a potent antiprotozoal agent. Imidocarb dipropionate is active against the parasite B. bovis with an IC50 of 87 μg/mL.
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Tetrasul (Standard)
0 ImagesReferencia número: HY-124901RNo. CAS: 2227-13-6Tetrasul (Standard) is the analytical standard of Tetrasul. This product is intended for research and analytical applications. Tetrasul is an acaricide. Tetrasul inhibits Tetranychus urticae and aphids on hops. Tetrasul has also been used in research of erythematous (type one) rosacea.
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SCR0911
0 ImagesReferencia número: HY-182711No. CAS: 1379615-30-1SCR0911 is an inhibitor of mycobacterial cytochrome bcc oxidase and Plasmodium falciparum cytochrome bc1. SCR0911 disrupts oxidative phosphorylation by binding to mycobacterial cytochrome bcc, binds to the Qi site of Plasmodium falciparum cytochrome bc1, inhibits mycobacterial cell growth and ATP synthesis, and exhibits broad-spectrum anti-mycobacterial and anti-malarial activities. SCR0911 can be used in research related to tuberculosis, malaria, and isolated persistent hypermethioninemia (iph).
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Liposomal Amphotericin B
0 ImagesReferencia número: HY-177849Synonyms: Amphotericin B liposomeLiposomal Amphotericin B (Amphotericin B liposome) is a liposomal formulation of Amphotericin B (HY-B0221) that can cross the blood-brain barrier. Liposomal Amphotericin B binds to fungal cell walls and releases Amphotericin B to bind Ergosterol (HY-N0181), inducing pore formation, ion leakage, and fungal cell death. Liposomal Amphotericin B exhibits fungicidal activity against a broad spectrum of fungal pathogens, also shows activity against Leishmania, and the liposomal formulation has lower acute and chronic toxicity as well as a lower risk of fungal resistance.
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DDD85646 (Standard)
0 ImagesReferencia número: HY-103056RNo. CAS: 1215010-55-1Synonyms: IMP-366 (Standard)DDD85646 (Standard) is the analytical standard of DDD85646 (HY-103056). This product is intended for research and analytical applications. DDD85646 (IMP-366) is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC50=2 nM; hNMT IC50=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis.
