Phosphatase
Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.
All Product Categories
-
Phosphatase Inhibitors
(514)
View all products
-
Phosphatase Agonists
(4)
View all products
-
Phosphatase Antagonists
(4)
View all products
-
Phosphatase Activators
(79)
View all products
-
Phosphatase Modulators
(7)
View all products
-
Phosphatase Chemical
(1)
View all products
-
Phosphatase Inducers
(2)
View all products
-
Phosphatase Degraders
(7)
View all products
-
Phosphatase Controls
(3)
View all products
-
Phosphatase Substrates
(4)
View all products
-
Phosphatase Ligands
(11)
View all products
-
Phosphatase Proteins
(66)
View all products
-
Phosphatase Related Products (729)
Related Products (729)
-
Recombinant Proteins (66)
-
Antibodies (40)
-
Related Compound Screening Libraries (1)
-
Luteolin 7-diglucuronide (Standard)
0 ImagesCat. No.: HY-N7269RCAS No.: 96400-45-2Luteolin 7-diglucuronide (Standard) is the analytical standard of Luteolin 7-diglucuronide. This product is intended for research and analytical applications. Luteolin 7-diglucuronide is the major flavonoid isolated from Aloysia triphylla and Verbena officinalis.
-
4',7-Dihydroxy-3'-methoxyflavanone
0 ImagesCat. No.: HY-N18421CAS No.: 13192-07-94',7-Dihydroxy-3'-methoxyflavanone is a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with an IC50 of 98.1 μM against human targets. 4',7-Dihydroxy-3'-methoxyflavanone can be used in research related to type 2 diabetes and obesity.
-
VHR-IN-4
0 ImagesCat. No.: HY-178294CAS No.: 1146616-15-0VHR-IN-4 (Compound SA7) is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC50 of 1.8 μM. VHR-IN-4 can be used for the research of cervical cancer.
-
VHR-IN-8
0 ImagesCat. No.: HY-178303CAS No.: 1146616-19-4VHR-IN-8 (Compound SA8) is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC50 of 2.4 μM. VHR-IN-8 can be used for the research of cervical cancer.
-
VHR-IN-1
0 ImagesCat. No.: HY-128024CAS No.: 956189-91-6VHR-IN-1 (Compound SA1) is a potent and selective VHR phosphatase inhibitor with an IC50 of 18 nM. VHR-IN-1 can inhibit the proliferation of cervix cancer cells and has anti-tumor activity.
-
CX08005
0 ImagesCat. No.: HY-117830CAS No.: 1256341-22-6CX08005 is a competitive PTP1B inhibitor. CX08005 can directly enhance the action of insulin in vivo and in vitro and improve insulin resistance.
-
RMC-3943
0 ImagesCat. No.: HY-141524CAS No.: 1801764-60-2
-
PTP1B-IN-33
0 ImagesCat. No.: HY-181239CAS No.: 77500-30-2
-
SHP504
0 ImagesCat. No.: HY-125259CAS No.: 2222280-83-1
-
HCN-IN-1
0 ImagesCat. No.: HY-186062CAS No.: 2234283-04-4HCN-IN-1 is a TLR4 inhibitor and HCN channel modulator with activity against HCN2 and HCN4.HCN-IN-1 inhibits TLR4-mediated alkaline phosphatase (SEAP) signal activity.HCN-IN-1 reduces HCN2 current across tested voltages, shifts voltage-dependent activation to more hyperpolarized potentials, slows activation kinetics, and does not affect deactivation process.HCN-IN-1 blocks HCN4 current.HCN-IN-1 exhibits analgesic, anti-inflammatory, and anti-anginal effects.HCN-IN-1 can be used for the research of inflammatory pain, neuropathic pain, heart failure, inflammation.
-
Tubulin-IN-62
0 ImagesCat. No.: HY-179385Tubulin-IN-62 is a tubulin inhibitor targeting the colchicine-binding site. Tubulin-IN-62 exhibits IC50 values of 17.2 nM and 19.3 nM against SKOV3 and HCC827 cells, respectively. Tubulin-IN-62 inhibits microtubule polymerization, arrests the cell cycle at the G2/M phase, and induces apoptosis. Tubulin-IN-62 demonstrates significant antitumor efficacy in vivo with good tolerability. Tubulin-IN-62 can be used in ovarian cancer and non-small cell lung cancer (NSCLC) research.
-
4-Bromolevamisole
0 ImagesCat. No.: HY-183947CAS No.: 56943-06-74-Bromolevamisole, an analogues of Levamisole (HY-A0106), is a phosphatase inhibitor. 4-Bromolevamisole potentiates the antineoplastic activity of 5-Fluorouracil (HY-90006), its analogues, or prodrugs thereof.4-Bromolevamisole can be used for cancer research.
-
PTP1B-IN-2 (Standard)
0 ImagesCat. No.: HY-100462RCAS No.: 1919853-46-5PTP1B-IN-2 (Standard) is the analytical standard of PTP1B-IN-2 (HY-100462). This product is intended for research and analytical applications. PTP1B-IN-2 is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 50 nM.
-
6-Hydroxybenzbromarone (Standard)
0 ImagesCat. No.: HY-135774RCAS No.: 152831-00-01-(Carboxymethyl)cyclohexanecarboxylic acid (Standard) is the analytical standard of 1-(Carboxymethyl)cyclohexanecarboxylic acid. This product is intended for research and analytical applications. 1-(Carboxymethyl)cyclohexanecarboxylic acid (1-Carboxycyclohexaneacetic acid; Gabapentin Impurity E) is a potential impurity in commercial preparations of the antiepileptic agent Gabapentin (HY-A0057). It is also used as a precursor for the synthesis of a serotonin (5-HT) receptor subtype 5-HT2A antagonist.
-
LMPTP inhibitor 1 dihydrochloride (Standard)
0 ImagesCat. No.: HY-111489BRCAS No.: 2310135-46-5LMPTP inhibitor 1 dihydrochloride (Standard) is the analytical standard of LMPTP inhibitor 1 (dihydrochloride) (HY-111489B). This product is intended for research and analytical applications. LMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A.
-
H-HomoArg-OH hydrochloride (Standard)
0 ImagesCat. No.: HY-W012340RCAS No.: 1483-01-8H-HomoArg-OH hydrochloride (Standard) is the analytical standard of H-HomoArg-OH hydrochloride (HY-W012340). This product is intended for research and analytical applications. H-HomoArg-OH hydrochloride (L-Homoarginine hydrochloride) is an orally active endogenous non-protein amino acid. H-HomoArg-OH hydrochloride acts as a weak alternative substrate for NOS and interferes with NO production, selectively inhibits tissue-nonspecific alkaline phosphatase (TNAP), and suppresses the uptake of arginine by y+-type transporters (system y+). H-HomoArg-OH hydrochloride increases tissue hArg concentrations in vivo, regulates amino acid homeostasis, and improves renal function and pathological features of diabetic nephropathy. H-HomoArg-OH hydrochloride can be used in studies related to diabetes and cardiomyopathy.
-
Dephostatin
0 ImagesCat. No.: HY-N15015CAS No.: 151606-30-3Dephostatin is a competitive protein tyrosine phosphatase (PTP) inhibitor that can be isolated from Streptomyces spp., with activity in the micromolar range.
