Pim
Pim kinases
The PIM kinase, also known as serine/threonine kinase plays an important role in cancer biology and is found in three different isoforms namely PIM-1, PIM-2, and PIM-3. Pim kinases are mainly responsible for cell cycle regulation, antiapoptotic activity and the homing and migration of receptor tyrosine kinases mediated via the JAK/STAT pathway.
Pim kinases are over-expressed in various types of tumors and regulate the activation of signaling pathways that are important for tumor cell proliferation, survival and expression of drug efflux proteins. This makes Pim kinases attractive targets for the development of anti-cancer chemotherapeutic drugs.
Pim Isoform Specific Products
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Pim Related Products (109)
Related Products (109)
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Antibodies (3)
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Pim Isoform Comparison
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Uzansertib phosphate (Standard)
0 ImagesSynonyms: INCB053914 phosphate (Standard)Uzansertib phosphate (Standard) is the analytical standard of Uzansertib phosphate (HY-101870B). This product is intended for research and analytical applications. Uzansertib (INCB053914) phosphate is an orally active, ATP-competitive pan-PIM kinase inhibitor with IC50s of 0.24 nM, 30 nM, 0.12 nM for PIM1, PIM2, PIM3, respectively. Uzansertib phosphate has broad anti-proliferative activity against a variety of hematologic tumor cell lines.
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Nuvisertib (Standard)
0 ImagesSynonyms: TP-3654 (Standard)
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Quercetagetin (Standard)
0 ImagesQuercetagetin (Standard) is the analytical standard of Quercetagetin. This product is intended for research and analytical applications. Quercetagetin (6-Hydroxyquercetin) is a flavonoid. Quercetagetin is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50, 0.34 μM). Anti-inflammatory and anticancer properties.
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Pim-1/2 kinase inhibitor 2
0 ImagesCat. No.: HY-157404CAS No.: 2918764-16-4Pim-1/2 kinase inhibitor 2 (compound 5b) is a competitive PIM-1 and PIM-2 kinase inhibitor with IC50s of 1.31 μM and 0.67 μM, respectively. Pim-1/2 kinase inhibitor 2 shows in-vitro low cytotoxicity against normal human lung fibroblast Wi-38 cell line and potent in-vitro anticancer activity against myeloid leukaemia (NFS-60), liver (HepG-2), prostate (PC-3), and colon (Caco-2) cancer cell lines.
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Pim1/AKK1-IN-1 (Standard)
0 ImagesCat. No.: HY-10371RCAS No.: 1093222-27-5Synonyms: LKB1/AAK1 dual inhibitor (Standard)Pim1/AKK1-IN-1 (Standard) is the analytical standard of Pim1/AKK1-IN-1 (HY-10371). This product is intended for research and analytical applications. Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.
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Protein kinase inhibitor 13
0 ImagesCat. No.: HY-169670CAS No.: 721964-45-0
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SMI-16a (Standard)
0 ImagesCat. No.: HY-101947RCAS No.: 587852-28-6Synonyms: PIM1/2 Kinase Inhibitor VI (Standard)
