Reverse Transcriptase
Reverse transcriptases (RTs) are enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription. Reverse transcriptases (RTs) use an RNA template and a short primer complementary to the 3' end of the RNA to direct the synthesis of the first strand cDNA.
Nucleoside reverse transcriptase inhibitors (NRTIs) block reverse transcriptase (an HIV enzyme). Non-nucleoside reverse transcriptase inhibitors (NNRTIs) bind to and block HIV reverse transcriptase. HIV uses reverse transcriptase to convert its RNA into DNA (reverse transcription). Blocking reverse transcriptase and reverse transcription prevents HIV from replicating.
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Reverse Transcriptase Related Products (265)
Related Products (265)
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Dapivirine-d11
0 ImagesCat. No.: HY-14266SCAS No.: 1329613-10-6Synonyms: TMC120-d11; R147681-d11Dapivirine-d11 is the deuterium labeled Dapivirine. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations.
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HIV-1 inhibitor-50
0 ImagesCat. No.: HY-152160CAS No.: 2834087-69-1
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HI-280
0 ImagesCat. No.: HY-105386CAS No.: 240417-31-6HI-280 is a human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitor. HI-280 can be used for the research of infection.
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Metacavir
0 ImagesCat. No.: HY-116154CAS No.: 120503-45-9Metacavir is an orally active, potent and specific nucleoside reverse transcriptase inhibitor against hepatitis B virus (HBV) with antiviral activity.
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Efavirenz (Standard)
0 ImagesSynonyms: DMP 266 (Standard); EFV (Standard); L-743726 (Standard)Efavirenz (Standard) is the analytical standard of Efavirenz. This product is intended for research and analytical applications. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture.
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Dapivirine (Standard)
0 ImagesSynonyms: TMC120 (Standard); R147681 (Standard)Dapivirine (Standard) is the analytical standard of Dapivirine. This product is intended for research and analytical applications. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations.
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VRX-480773
0 ImagesCat. No.: HY-19869CAS No.: 878670-89-4VRX-480773 is an efficient non-nucleoside reverse transcriptase inhibitor (NNRTI), used for HIV infection. VRX-480773 has high specificity for HIV-1, with an EC50 for wild-type HIV-1 being 0.14 nM. VRX-480773 does not inhibit HIV-2, HBV or HCV, and has no effect on human DNA polymerase α/β. VRX-480773 retains inhibitory activity against Efavirenz (HY-10572) resistant strains, with EC50s mostly < 1 nM. VRX-480773 can be used for research on AIDS.
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Abacavir (Standard)
0 ImagesAbacavir (Standard) is the analytical standard of Abacavir. This product is intended for research and analytical applications. Abacavir is an orally active and competitive nucleoside reverse transcriptase inhibitor. Abacavir can inhibits the replication of HIV. Abacavir shows anticancer activity in prostate cancer cell lines. Abacavir can trespass the blood-brain-barrier and suppresses telomerase activity.
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Adefovir dipivoxil (Standard)
0 ImagesSynonyms: GS 0840 (Standard)Adefovir dipivoxil (Standard) is the analytical standard of Adefovir dipivoxil. This product is intended for research and analytical applications. Adefovir dipivoxil is an orally active adenosine analog and Adefovir prodrug. Adefovir dipivoxil inhibits DNA synthesis, activates the ATR signaling pathway, and disrupts the KCTD12-CDK1 interaction. Adefovir dipivoxil has antiviral activity against PRV, HBV, and orthopoxviruses. Adefovir dipivoxil has inhibitory effects on both lamivudine-resistant and wild-type strains. Adefovir dipivoxil has antitumor activity against lung and colon cancer.
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NNRT-IN-9
0 ImagesCat. No.: HY-174303NNRT-IN-9 (Compound EG28) is a non-nucleoside reverse transcriptase (NNRT) inhibitor. NNRT-IN-9 has potent antiviral and anti-resistance activity against wild-type (WT) HIV-1 and various clinically relevant mutations (E138K and K103N + Y181C) with EC50s of 55, 67 and 3910 nM, respectively. NNRT-IN-9 can be used for acquired immune deficiency syndrome (AIDS) research.
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HI-207
0 ImagesCat. No.: HY-108930CAS No.: 244268-79-9HI-207 is a non-nucleoside reverse transcriptase inhibitor. HI-207 has anti-HIV activity (PBMC/p24 inhibition assay: IC50 = 0.27 μM). HI-207 can be used for HIV infection research.
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R-82150
0 ImagesCat. No.: HY-19111CAS No.: 126320-77-2Synonyms: TIBO-R 82150R-82150 (TIBO-R 82150) is an HIV-1 reverse transcriptase inhibitor that blocks the reverse transcription of viral RNA by binding to the non-substrate binding site of reverse transcriptase, thereby inhibiting viral replication. R-82150 does not inhibit the replication of HIV-2, other RNA viruses, and DNA viruses.
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Loviride (Standard)
0 ImagesSynonyms: R 89439 (Standard)Loviride (Standard) is the analytical standard of Loviride. This product is intended for research and analytical applications. Loviride (R 89439) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), with an IC50 of 0.3 μM for reverse transcriptase from HIV-1. Loviride (R 89439) inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells.
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Lamivudine-13C,15N2
0 ImagesCat. No.: HY-135330CAS No.: 1391052-30-4Lamivudine-13C,15N2 is a labelled impurity of Lamivudine (BCH-189). Lamivudine is a nucleoside reverse transcriptase inhibitors (NRTIs), and can inhibit HIV reverse transcriptase 1/2 and the reverse transcriptase of hepatitis B virus.
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Mniopetal E
0 ImagesCat. No.: HY-N14288CAS No.: 158761-02-5Mniopetal E is a reverse transcriptase inhibitor found in Mniopetalum sp. 87256.
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U 80493
0 ImagesCat. No.: HY-183886CAS No.: 136816-67-6U 80493 is a HIV-1 reverse transcriptase inhibitor with IC50 of 20 μM. U 80493 can be used for the research of acquired immunodeficiency syndrome.
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Delavirdine (Standard)
0 ImagesSynonyms: U 90152 (Standard); BHAP-U 90152 (Standard)Delavirdine (Standard) is the analytical standard of Delavirdine. This product is intended for research and analytical applications. Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC50=0.26?μM) over DNA polymerase?α?(IC50=440 μM) and polymerase?δ (IC50>550?μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs.
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AzddMeC (Standard)
0 ImagesCat. No.: HY-105268RCAS No.: 87190-79-2Synonyms: CS-92 (Standard)AzddMeC (Standard) is the analytical standard of AzddMeC (HY-105268). This product is intended for research and analytical applications. AzddMeC (CS-92) is an antiviral nucleoside analogue and a potent potent, selective and orally active HIV-1 reverse transcriptase and HIV-1 replication inhibitor. In HIV-1-infected human PBM cells and HIV-1-infected human macrophages, the EC50 values of AzddMeC are 9 nM and 6 nM, respectively. AzddMeC is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Emtricitabine-15N,d2
0 ImagesCat. No.: HY-17427SCAS No.: 2714436-53-8Synonyms: BW1592-15N,d2Emtricitabine-15N,d2 is a 15N-labeled and deuterium labeled Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.
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Agrocybin
0 ImagesAgrocybin is an antifungal peptide that exerts antifungal activity against several fungal species but lacks inhibitory activity against bacteria. Agrocybin attenuates the activity of HIV-1 reverse transcriptase.
