Topoisomerase
Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. Topoisomerases are isomerase enzymes that act on the topology of DNA. Type I topoisomerase cuts one strand of a DNA double helix, relaxation occurs, and then the cut strand is reannealed. Type I topoisomerases are subdivided into two subclasses: type IA topoisomerases, which share many structural and mechanistic features with the type II topoisomerases, and type IB topoisomerases, which utilize a controlled rotary mechanism. Type II topoisomerase cuts both strands of one DNA double helix, pass another unbroken DNA helix through it, and then reanneal the cut strands. This class is also split into two subclasses: type IIA and type IIB topoisomerases, which possess similar structure and mechanisms.
Topoisomerase Isoform Specific Products
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Topoisomerase Inhibitors
(769)
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Topoisomerase Agonists
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Topoisomerase Modulator
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Topoisomerase Inducer
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Topoisomerase Degraders
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Topoisomerase Controls
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Topoisomerase Ligands
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Topoisomerase Proteins
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DNA topoisomerase II Proteins
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Topoisomerase Related Products (847)
Related Products (847)
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Recombinant Proteins (1)
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Antibodies (4)
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Topoisomerase Isoform Comparison
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Voreloxin (Standard)
0 ImagesCat. No.: HY-10534RCAS No.: 175414-77-4Synonyms: SNS-595 (Standard); Vosaroxin (Standard); AG 7352 (Standard)Voreloxin (Standard) is the analytical standard of Voreloxin (HY-10534). This product is intended for research and analytical applications. Voreloxin (SNS-595; Vosaroxin; AG 7352) is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.
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Amsacrine hydrochloride (Standard)
0 ImagesSynonyms: m-AMSA hydrochloride (Standard); acridinyl anisidide hydrochloride (Standard)Amsacrine (hydrochloride) (Standard) is the analytical standard of Amsacrine (hydrochloride). This product is intended for research and analytical applications. Amsacrine hydrochloride (m-AMSA hydrochloride; acridinyl anisidide hydrochloride) is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells.
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Besifloxacin Hydrochloride (Standard)
0 ImagesCat. No.: HY-17028RCAS No.: 405165-61-9Besifloxacin (Hydrochloride) (Standard) is a fourth generation fluoroquinolone antibiotic. Besifloxacin Hydrochloride (Standard) is a DNA gyrase and topoisomerase IV inhibitor. Besifloxacin Hydrochloride (Standard) has broad-spectrum antibacterial activity, it is effective against Gram-negative and Gram-positive aerobic and anaerobic strains and reduces the incidence of drug resistance. Besifloxacin Hydrochloride (Standard) has anti-inflammatory activity. Besifloxacin Hydrochloride (Standard) can be used in bacterial conjunctivitis research.
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Albicidin
0 ImagesCat. No.: HY-108988CAS No.: 1622253-00-2Albicidin is a peptide antibiotic with phytotoxic activity. Albicidin potently inhibits bacterial and plant DNA gyrase at nanomolar concentrations, blocks DNA replication, and exhibits excellent antibacterial efficacy against multidrug-resistant bacteria. Albicidin possesses bactericidal activity against Gram-positive and Gram-negative microorganisms, and acts as a virulence factor for the systemic plant infection by Xanthomonas albilineans. Albicidin can be used in studies related to bacterial infections and sugarcane leaf blight.
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Pixantrone-d8
0 ImagesCat. No.: HY-13727ASSynonyms: BBR 2778-d8
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Amsacrine isethionate
0 ImagesCat. No.: HY-13551CCAS No.: 80277-14-1Synonyms: m-AMSA isethionate; Acridinyl anisidide isethionateAmsacrine isethionate (m-AMSA isethionate) is a Topoisomerase II inhibitor. Amsacrine isethionate intercalates into DNA. Amsacrine isethionate induces Ca2+-mediated inactivation of ERK, and also downregulates AKT, promoting MCL1 downregulation mediated by GSK3β via reducing the phosphorylation level of GSK3β. Amsacrine isethionate induces Apoptosis by activating Caspase-9 and Caspase-3. Amsacrine isethionate blocks HERG potassium channels in the open/inactivated state. Amsacrine isethionate induces chromosomal aberrations and sister chromatid exchanges, and inhibits the synthesis of RNA and DNA. Amsacrine isethionate exhibits anti-leukemic activity. Amsacrine isethionate causes cardiac repolarization disorders, QT interval prolongation, ventricular arrhythmias, and increases the risk of sudden cardiac death. Amsacrine isethionate can be used in research related to acute myeloid leukemia, lymphoma and progressive malignancies.
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CP-115953
0 ImagesCat. No.: HY-118569CAS No.: 136440-70-5CP-115953 is an antitumor fluoroquinolone compound that targets eukaryotic topoisomerase II and Escherichia coli DNA gyrase. CP-115953 inhibits ATP hydrolysis and DNA relaxation by stimulating enzyme-mediated DNA cleavage, and enhances the expression of immune-related cytokines. CP-115953 is applicable for research on human cancers.
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(S)-10-Hydroxycamptothecin (Standard)
0 ImagesSynonyms: 10-HCPT (Standard); 10-Hydroxycamptothecin (Standard)(S)-10-Hydroxycamptothecin (Standard) is the analytical standard of (S)-10-Hydroxycamptothecin. This product is intended for research and analytical applications. (S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment.
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Dichlorogelignate
0 ImagesCat. No.: HY-N12747CAS No.: 164030-91-5Dichlorogelignate (compound 4) is a selective inhibitor of topoisomerase II (Topo II). Dichlorogelignate has 100% inhibition at 50 μM.
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Pefloxacin mesylate dihydrate
0 ImagesSynonyms: Pefloxacinium mesylate dihydratePefloxacin (Pefloxacinium) mesylate dihydrate is a broad spectrum antibiotic. Pefloxacin mesylate dihydrate blocks DNA replication by inhibiting DNA gyrase. Pefloxacin mesylate dihydrate inhibits DNA relaxation catalyzed by topoisomerase I with an IC50 of 45 μg/mL. Pefloxacin mesylate dihydrate exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC90s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin mesylate dihydrate has anti-Plasmodium yoelii infection activity. Pefloxacin mesylate dihydrate increase UVA-induced edema and immunesuppression. Pefloxacin mesylate dihydrate can be used for infection studies.
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Bethoxazin
0 ImagesBethoxazin is a yeast DNA topoisomerase II inhibitor with an IC50 of 5.3 μM, and also a broad-spectrum industrial microbicide and covalent adduct-forming agent. Bethoxazin inhibits the catalytic activity of yeast DNA topoisomerase II by reacting with the key free cysteine thiol group on the enzyme. Bethoxazin forms covalent adducts with molecules containing free thiol groups. Bethoxazin inhibits the growth of yeast cells. Bethoxazin can be used in studies related to the growth of fungi, molds and algae.
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10NH2-11F-Camptothecin TFA
0 ImagesCat. No.: HY-156516ACAS No.: 2873461-64-210NH2-11F-Camptothecin TFA is a Camptothecin (HY-16560) analogue that serves as an ADC cytotoxin for the synthesis of antibody-drug conjugates (ADCs). 10NH2-11F-Camptothecin TFA has anticancer effects (WO2022246576A1; compound 140).
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Eupolauridine
0 ImagesCat. No.: HY-N15319CAS No.: 58786-39-3Synonyms: CanangineEupolauridine (Canangine) is a selective DNA topoisomerase II inhibitor with IC50 values of 20 μM for fungal topoisomerase I and 33 μM for human topoisomerase I. Eupolauridine exerts antifungal activity by inhibiting the catalytic activity of topoisomerase II and stabilizing its cleavage complex with DNA, leading to DNA damage. Eupolauridine is promising for research of fungal infectious diseases.
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Lurtotecan dihydrochloride
0 ImagesSynonyms: GI147211 dihydrochloride; OSI-211 dihydrochlorideLurtotecan dihydrochloride (GI147211), a semisynthetic Camptothecin analog, is a topoisomerase I inhibitor. Lurtotecan dihydrochloride has anticancer effects.
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Govitecan
0 ImagesCat. No.: HY-187637CAS No.: 1918106-06-5Govitecan is a topoisomerase I inhibitor and also a linker-payload compound for antibody-drug conjugates (ADCs), with SN-38 as its active component. Govitecan serves as the linker-drug moiety of ADCs targeting CDH17-expressing cancer cells. Govitecan acts as the cytotoxic payload component of ADCs targeting Trop-2. Govitecan can be used in research related to colorectal cancer, gastric cancer, pancreatic cancer, liver cancer, metastatic triple-negative breast cancer, and other conditions.
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Topoisomerase IIα-IN-5
0 ImagesCat. No.: HY-152187CAS No.: 3037545-23-3Topoisomerase IIα-IN-5 is a topoisomerase II (topo II) α catalytic inhibitor. Topoisomerase IIα-IN-5 intercalates into DNA and binds to the DNA minor groove. Topoisomerase IIα-IN-5 exhibits better efficacy and less genotoxicity than Etoposide (HY-13629).
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7-Methoxy-9-methylfuro[2,3-b]-quinoline-4,5,8(9H)-trione
![7-Methoxy-9-methylfuro[2,3-b]-quinoline-4,5,8(9H)-trione](https://file.medchemexpress.com/product_pic/hy-169261.gif "Click to View 7-Methoxy-9-methylfuro[2,3-b]-quinoline-4,5,8(9H)-trione Product Detail")
0 ImagesCat. No.: HY-169261CAS No.: 859304-28-27-Methoxy-9-methylfuro[2,3-b]-quinoline-4,5,8(9H)-trione is a synthetic intermediate that can been used in the synthesis of the alkaloid Acronycidine.
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Viquidacin
0 ImagesCat. No.: HY-14780CAS No.: 904302-98-3Synonyms: NXL 101Viquidacin (NXL 101) is an antibiotic with inhibitory activity against topoisomerase IV and DNA gyrase. Viquidacin exhibits antibacterial activity against gram positive bacterial by inhibiting the supercoiling, decatenation and relaxation in strains Staphylococcus aureus and Escherichia coli in micromolar levels. Viquidacin inhibits S. aureus wildtype and mutants with MIC of 2-128 mg/L.
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Levofloxacin-d3 hydrochloride
0 ImagesCat. No.: HY-B0330BS1CAS No.: 1173021-78-7Synonyms: (-)-Ofloxacin-d3 hydrochlorideLevofloxacin-d3 ((-)-Ofloxacin-d3) hydrochlorideis deuterium labeled Levofloxacin (hydrochloride). Levofloxacin ((-)-Ofloxacin) hydrochloride is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrochloride inhibits the DNA gyrase and topoisomerase IV. Levofloxacin hydrochloride can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin hydrochloride shows anti-orthopoxvirus activity.
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Bakuchicin
0 ImagesBakuchicin (Allopsoralen) is a compound that can be found in Psoralea corylifolia. It has certain inhibitory activity against topoisomerase II. In the cell model infected with Simian virus 40 (SV40), the IC50 of Bakuchicin against topoisomerase II is 404 μM. Bakuchicin can be used in the research of the anti-infection field.
