Calmodulin
Calmodulin; CaM; Calcium-Modulated Protein
Calmodulin is the highly conserved, calcium-sensitive protein, that acts as the calcium ion sensor in cells, Ca2+-dependently binds to target proteins, and converts Ca2+ concentrations into cellular signals. Calmodulin has four different Ca2+ binding sites named EF-hand for the sensing of Ca2+ signaling with different amplitude, duration, and location. Calmodulin dysfunction could lead to myocardial contractile problems, neuronal damage, or tumor angiogenesis dysregulation, which may cause cardiovascular diseases, neurological diseases, or cancer[1][2][3].
References:
- [1]. Means AR, et al., Calmodulin--an intracellular calcium receptor. Nature. 1980 May 8;285(5760):73-7. doi: 10.1038/285073a0 [Content Brief]
- [2]. Kawasaki H, et al., Molecular Dynamics Study of the Changes in Conformation of Calmodulin with Calcium Binding and/or Target Recognition. Sci Rep. 2019 Jul 23;9(1):10688. [Content Brief]
- [3]. Crotti L, et al., Clinical presentation of calmodulin mutations: the International Calmodulinopathy Registry. Eur Heart J. 2023 Sep 14;44(35):3357-3370. [Content Brief]
Calmodulin Isoform Specific Products
All Product Categories
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Calmodulin Related Products (71)
Related Products (71)
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Antibodies (4)
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Calmodulin Isoform Comparison
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Acremonidin A
0 ImagesCat. No.: HY-N10198CAS No.: 701914-77-4Acremonidin A is a potent calmodulin (CaM) inhibitor found in Purpureocillium lilacinum. Acremonidin A binds to the human calmodulin (hCaM) biosensor hCaM M124C-mBBr, with Kd of 19.40 nM.
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CBP-501 acetate
0 ImagesCat. No.: HY-16129APurity: 99.75%CBP-501 acetate, a cell-permeable calmodulin-binding peptide and a G2-abrogating drug candidate, inhibits the activity of multiple Ser216-specific kinases, such as MAPKAP-K2, C-Tak1, CHK1 and CHK2, with IC50 values of 0.9 μM, 1.4 μM 3.4 μM and 6.5 μM, respectively. CBP-501 acetate is used for various types of cancer.
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4-Hydroxy-3,3',5-trimethoxybibenzyl
0 ImagesCat. No.: HY-N21792CAS No.: 213842-42-34-Hydroxy-3,3',5-trimethoxybibenzyl is a synthetic bibenzyl analog with spasmolytic activity. It inhibits spontaneous contractions of isolated guinea pig ileum. In the presence of Ca2+, 4-Hydroxy-3,3',5-trimethoxybibenzyl also alters the electrophoretic mobility of bovine brain calmodulin (calmodulin), supporting its interaction with CaM. It can be used in studies of smooth muscle contraction and calmodulin-related processes.
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DY-9760e
0 ImagesCat. No.: HY-19230CAS No.: 179185-73-0DY-9760e is a calmodulin (CaM) inhibitor. DY-9760e selectively inhibits the activity of various calmodulin-dependent enzymes by antagonizing the Ca²⁺/CaM complex, exhibiting the strongest inhibitory activity against nNOS, CaM kinase II, and calcineurin (Ki: 0.9, 1.4, and 2.0 μM, respectively). DY-9760e inhibits excessive nitric oxide production and protein tyrosine nitration, as well as the activation of calpain and caspase-3. DY-9760e reduces infarct size, improves cardiac function, and inhibits oxidative stress and cell death. DY-9760e can be used in research on the treatment of myocardial infarction, cerebral ischemia, and other diseases.
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Beauverolide Ja
0 ImagesCat. No.: HY-142087CAS No.: 76265-41-3Beauverolide Ja, a cyclotetradepsipeptide, is a potent calmodulin (CaM) inhibitor with a Kd of 0.078 μM and a Ki of 0.39 μM for Ca2+-CaM. Beauverolide Ja is a secondary metabolite of Isaria fumosorosea.
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Moxaverine hydrochloride
0 ImagesMoxaverine hydrochloride is a phosphodiesterase (PDE) inhibitor. Moxaverine hydrochloride also interacts with calmodulin (calmodulin), thereby enhancing the inhibition of calmodulin-dependent PDE. Moxaverine hydrochloride can be used in studies related to microcirculation regulation and ocular tissue distribution.
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RU 45144
0 ImagesCat. No.: HY-118242CAS No.: 119286-92-9RU 45144 is an anti-estrogen compound that has the activity of antagonizing the binding of estrogen receptors to calmodulin. RU 45144 can inhibit the binding of estrogen receptors to calmodulin, and its effect is similar to that of tamoxifen. Its anti-estrogen effect may be related to specific side chains in the molecular structure, and the steroid skeleton may be involved in its anti-proliferative activity.
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Encecalinol
0 ImagesCat. No.: HY-N12405CAS No.: 88728-56-7Encecalinol, extracted from aerial parts of Ageratina grandifolia, is a potent inhibitor of calmodulin inhibitor.
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Cloxacepride
0 ImagesCat. No.: HY-106645CAS No.: 65569-29-1Cloxacepride is an orally active and potent antiallergic agent. Cloxacepride is a CaM (calmodulin) antagonist. Cloxacepride has anti-PCA (passive cutaneous anaphylaxis) activity.
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Calmodulin-Dependent Protein Kinase II (281-309)
0 ImagesCat. No.: HY-P1874CAS No.: 116826-37-0Calmodulin-Dependent Protein Kinase II (281-309) is a peptide of calcium/calmodulin-dependent protein kinase II (CaM-kinase II).
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CV-159
0 ImagesCat. No.: HY-19025CAS No.: 86384-98-7CV-159 is a unique dihydropyridine Ca2+ antagonist with an anti-calmodulin (CaM) action, and has antiinflammatory activities.
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MLCK Peptide
0 ImagesCat. No.: HY-P10165CAS No.: 209251-64-9
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CALM3 Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS01842CALM3 Human Pre-designed siRNA Set A contains three designed siRNAs for CALM3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Components
CALM3 siRNA-1: 5 nmol (HPLC)
CALM3 siRNA-2: 5 nmol (HPLC)
CALM3 siRNA-3: 5 nmol (HPLC)
siRNA Negative Control: 5 nmol (HPLC)
FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
GAPDH siRNA Positive Control: 5 nmol (HPLC)
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Fasciculic acid A
0 ImagesCat. No.: HY-N7733CAS No.: 126906-00-1Fasciculic acid A is a steroid that can be isolated from Hypholoma lateritium. Fasciculic acid B has antiinflammatory and calmodulin antagonistic activity.
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Bepridil hydrochloride (Standard)
0 ImagesSynonyms: CERM 1978 (Standard); Org 5730 hydrochloride (Standard)Bepridil hydrochloride (Standard) (CERM 1978 (Standard);Org 5730 hydrochloride (Standard)) is the analytical standard of Bepridil hydrochloride (HY-103315). This product is intended for research and analytical applications. Bepridil hydrochloride is an orally active non-selective calcium channel antagonist with multi-ion channel blocking activity. Bepridil hydrochloride modulates Calmodulin, the 20S proteasome, T-type/L-type calcium channels, cardiac sodium channels, multiple potassium channels, γ-secretase, β-secretase, and mitoKATP/sarcKATP channels. Bepridil hydrochloride acts as a hydroxyl radical scavenger, regulates mitochondrial and intracellular calcium handling, and exerts antiarrhythmic, antianginal, and cardioprotective effects. Bepridil hydrochloride alters amyloid precursor protein processing, reduces β-amyloid and thalamic calcium levels, restores seladin-1/DHCR24 expression, and improves sensorimotor recovery after cerebral ischemia. Bepridil hydrochloride also exhibits potent inhibitory effects on SARS-CoV-2 replication. Bepridil hydrochloride is used in studies related to stable angina, arrhythmias, cerebral ischemia, Alzheimer's disease, and SARS-CoV-2 infection.
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Aprindine hydrochloride (Standard)
0 ImagesCat. No.: HY-A0236ARCAS No.: 33237-74-0Aprindine hydrochloride (Standard) is the analytical reference standard of Aprindine hydrochloride (HY-A0236A). This product is used for research and analytical applications. Aprindine hydrochloride is an Ib-class anti-arrhythmic agent. Aprindine hydrochloride mainly exerts its effect by blocking sodium channels (INa), thereby reducing the excitability and conduction velocity of cardiac muscle cells. Aprindine hydrochloride significantly inhibits delayed potassium currents, which helps to prolong the atrial effective refractory period (AERP) and inhibit the occurrence of atrial fibrillation. Aprindine hydrochloride can also regulate intracellular calcium ion concentration by inhibiting Na+/Ca2+ exchange current (INCX), thereby further stabilizing cardiac electrical activity. Aprindine hydrochloride can be used for the study of atrial fibrillation (AF) and ventricular arrhythmias.
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Bepridil-d5 hydrochloride
0 ImagesCat. No.: HY-103315SSynonyms: CERM 1978-d5; Org 5730-d5 hydrochlorideBepridil-d5 hydrochloride (CERM 1978-d5; Org 5730-d5 hydrochloride) is the deuterated-labeled Bepridil hydrochloride (HY-103315). Bepridil hydrochloride (CERM 1978; Org 5730 hydrochloride) is an orally active non-selective calcium channel antagonist with multi-ion channel blocking activity. Bepridil hydrochloride modulates Calmodulin, the 20S proteasome, T-type/L-type calcium channels, cardiac sodium channels, multiple potassium channels, γ-secretase, β-secretase, and mitoKATP/sarcKATP channels. Bepridil hydrochloride acts as a hydroxyl radical scavenger, regulates mitochondrial and intracellular calcium handling, and exerts antiarrhythmic, antianginal, and cardioprotective effects. Bepridil hydrochloride alters amyloid precursor protein processing, reduces β-amyloid and thalamic calcium levels, restores seladin-1/DHCR24 expression, and improves sensorimotor recovery after cerebral ischemia. Bepridil hydrochloride also exhibits potent inhibitory effects on SARS-CoV-2 replication. Bepridil hydrochloride is used in studies related to stable angina, arrhythmias, cerebral ischemia, Alzheimer's disease, and SARS-CoV-2 infection.
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Calm2 Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS26152Calm2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Calm2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Components
Calm2 siRNA-1: 5 nmol (HPLC)
Calm2 siRNA-2: 5 nmol (HPLC)
Calm2 siRNA-3: 5 nmol (HPLC)
siRNA Negative Control: 5 nmol (HPLC)
FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
GAPDH siRNA Positive Control: 5 nmol (HPLC)
