2. Signaling Pathways
  3. Immunology/Inflammation
  4. DOCK
  5. DOCK Inhibitor

DOCK Inhibitor

DOCK Inhibitor (1):

Cat. No. Product Name Effect Purity
  • HY-153128
    DOCK2-IN-1
    		Inhibitor
    DOCK2-IN-1 (compound 3), a CPYPP (HY-110100) analogue, is an inhibitor of DOCK2 as well (IC50=19.1 μM). DOCK2-IN-1 binds to DOCK2 DHR-2 domain in a reversible manner to inhibits its catalytic activity. DOCK2-IN-1 blocks the activation of both chemokine receptor- and antigen receptor-mediated Rac in lymphocytes. DOCK2-IN-1 significantly suppresses chemotactic response and T cell activation.