mAChR
Muscarinic acetylcholine receptor
mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.
mAChR Isoform Specific Products
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mAChR Inhibitors
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mAChR Agonists
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mAChR Antagonists
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mAChR Activators
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mAChR Modulators
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mAChR Inducer
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mAChR Controls
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mAChR Ligands
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mAChR Related Products (731)
Related Products (731)
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Antibodies (2)
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mAChR Isoform Comparison
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CDD0102 hydrochloride
0 ImagesCat. No.: HY-U00230ACAS No.: 1196130-86-5CDD0102 Hydrochloride is a potent M1 Muscarinic receptor agonist.
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Piperidolate (Standard)
0 ImagesCat. No.: HY-B0962ARCAS No.: 82-98-4Piperidolate (Standard) is the analytical standard of Piperidolate. This product is intended for research and analytical applications. Piperidolate is a cholinergic antagonist. Piperidolate prevents ventricular fibrillation during hypothermic cardiac manipulations to support cardiac procedures post-preoperative defibrillation. Piperidolate causes dose-dependent cardiac depression. Piperidolate can be used for the research of ventricular fibrillation.
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(±)-Darifenacin N-Oxide
0 ImagesCat. No.: HY-W746075ACAS No.: 2416229-88-2(±)-Darifenacin N-Oxide is the impurity of Darifenacin (HY-A0033). Darifenacin (UK-88525) is a selective and orally active M3 muscarinic receptor (M3R) antagonist with a pKi of 8.9.
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Tolterodine (Standard)
0 ImagesCat. No.: HY-A0024RCAS No.: 124937-51-5Synonyms: (R)-(+)-Tolterodine (Standard); (+)-Tolterodine (Standard); (R)-Tolterodine (Standard); PNU-200583 (Standard)Tolterodine (Standard) is the analytical standard of Tolterodine. This product is intended for research and analytical applications. Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.
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Dimethyl-W84 dibromide
0 ImagesCat. No.: HY-122491CAS No.: 402475-33-6Dimethyl-W84 (dibromide) modulates M2 muscarinic acetylcholine receptors. Dimethyl-W84 (dibromide) can be used in nervous system related research.
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Baogongteng A
0 ImagesCat. No.: HY-125700CAS No.: 74239-84-2Synonyms: (-)-Bao Gong Teng ABaogongteng A ((-)-Bao Gong Teng A) is an optically active tropane alkaloid with hypotensive and miotic activity, and can be isolated from the Chinese herb Erycibe obtusifolia Benth. Baogongteng A is also a muscarinic agonist. Baogongteng A can be used for cardiovascular and glaucoma research.
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Anisodine hydrobromide
0 ImagesCat. No.: HY-127022ACAS No.: 76822-34-9Synonyms: Daturamine hydrobromide; α-Hydroxyscopolamine hydrobromideAnisodine (Daturamine) hydrobromide is a neuroprotective compound that reduces exacerbated M1, M2, M4, and M5 receptor expression in brain tissues under hypoxia/reoxygenation conditions. Anisodine hydrobromide inhibits calcium ion influx and reactive oxygen species (ROS)levels. Anisodine hydrobromide leads to decreased aspartate levels during hypoxia.
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Tolterodine dimer
0 ImagesCat. No.: HY-W708197CAS No.: 854306-72-2Tolterodine dimer is the impurity of Tolterodine (HY-A0024). Tolterodine is a potent muscarinic receptor antagonist.
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Oxyphencyclimine hydrochloride (Standard)
0 ImagesOxyphencyclimine (hydrochloride) (Standard) is the analytical standard of Oxyphencyclimine (hydrochloride). This product is intended for research and analytical applications. A new tertiary amine, Oxyphencyclimine hydrochloride，has been investigated for its effects on the peripheral parasympathetic system.
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Revatropate
0 ImagesCat. No.: HY-126184CAS No.: 149926-91-0Synonyms: UK-112166Revatropate is an antimuscarinic compound. Revatropate has a much greater inhibitory effect on M1 and M3 receptors than on the M2 subtype. Revatropate is used in the study of urge urinary incontinence and functional bowel disorders.
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Acetylcholine iodide (Standard)
0 ImagesSynonyms: ACh iodide (Standard)Acetylcholine (iodide) (Standard) is the analytical standard of Acetylcholine (iodide). This product is intended for research and analytical applications. Acetylcholine iodide (ACh iodide) is a common neurotransmitter found in the central and peripheral nerve system.
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Olanzapine hydrochloride
0 ImagesCat. No.: HY-14541ACAS No.: 783334-36-1Synonyms: LY170053 hydrochlorideOlanzapine hydrochloride is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine hydrochloride is an atypical antipsychotic.
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NNC 11-1607
0 ImagesCat. No.: HY-119333CAS No.: 250649-13-9NNC 11-1607 is a selective M1/M4 muscarinic acetylcholine receptor (mAChR) agonist. NNC 11-1607 inhibits Forskolin (HY-15371)-stimulated cAMP accumulation in Chinese hamster ovary cells expressing the human M2 or M4 mAChR. NNC 11-1607 is promising for research of central nervous system disorders, such as Alzheimer’s disease and schizophrenia.
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AC260584 (Standard)
0 ImagesCat. No.: HY-100336RCAS No.: 560083-42-3
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Desiodomethyl 4-DAMP
0 ImagesCat. No.: HY-134081CAS No.: 97762-23-7Desiodomethyl 4-DAMP is a muscarinic receptor antagonist.
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Batefenterol (Standard)
0 ImagesCat. No.: HY-12980RCAS No.: 743461-65-6Synonyms: GSK961081 (Standard); TD-5959 (Standard)Batefenterol (Standard) is the analytical standard of Batefenterol. This product is intended for research and analytical applications. Batefenterol (GSK961081;TD-5959) is a novel muscarinic receptor antagonist and β2-adrenoceptor agonist; displays high affinity for hM2, hM3 muscarinic and hβ2-adrenoceptor with Ki values of 1.4, 1.3 and 3.7 nM, respectively.
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3-Hydroxy darifenacin
0 ImagesCat. No.: HY-149504CAS No.: 206048-82-03-Hydroxy darifenacin is a metabolite of Darifenacin (HY-A0033). 3-Hydroxy darifenacin is an antagonist of M1-5 muscarinic receptors with Kis values of 17.78, 79.43, 2.24, 36.31 and 6.17 nM, respectively in CHO cells.
