nAChR
Nicotinic acetylcholine receptors
nAChRs (nicotinic acetylcholine receptors) are neuron receptor proteins that signal for muscular contraction upon a chemical stimulus. They are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the presynaptic and postsynaptic sides of theneuromuscular junction. Nicotinic acetylcholine receptors are the best-studied of the ionotropic receptors. Like the other type of acetylcholine receptor-the muscarinic acetylcholine receptor (mAChR)-the nAChR is triggered by the binding of the neurotransmitter acetylcholine (ACh). Just as muscarinic receptors are named such because they are also activated by muscarine, nicotinic receptors can be opened not only by acetylcholine but also by nicotine —hence the name "nicotinic".
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nAChR Related Products (484)
Related Products (484)
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Antibodies (5)
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(R)-Monepantel
0 ImagesSynonyms: (R)-AAD1566(R)-Monepantel (AAD2224) is the optical R-enantiomer of monepantel. (R)-Monepantel has no nematocidal effect, is inactive.
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Flupyradifurone-d5
0 ImagesCat. No.: HY-W750777CAS No.: 2732873-32-2Flupyradifurone-d5 is the deuterium labeled Flupyradifurone (HY-145295). Flupyradifurone is a systemic?nAChR?agonist that interferes with signal transduction in the central nervous system of sucking pests. Flupyradifurone can be used as a butenolide?insecticide.
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nAChR antagonist 2
0 ImagesCat. No.: HY-180559nAChR antagonist 2 is a selective nAChR antagonist. nAChR antagonist 2 inhibits nAChR subtype including hα9α10, hα9, and hα7 with IC50 values of 16.0 nM, 26.2 nM, and 336.3 nM, respectively, in Xenopus oocytes. nAChR antagonist 2 suppresses ATP-induced IL-1β release at nanomolar concentrations. nAChR antagonist 2 can be used for nonopioid analgesics and immunomodulators research.
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Atracurium
0 ImagesCat. No.: HY-B0292CAS No.: 64228-79-1Synonyms: BW-33A free acidtracurium (BW-33A free acid) is a potent, competitive and non-depolarizing neuromuscular blocking agent.Atracurium also is an AChR receptor antagonist. Atracurium induces bronchoconstriction and neuromuscular blockade. Atracurium promotes astroglial differentiation.
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Monepantel (Standard)
0 ImagesSynonyms: AAD1566 (Standard); NUZ-001 (Standard)Monepantel (Standard) is the analytical standard of Monepantel. This product is intended for research and analytical applications. Monepantel is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits.
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(±)-Anatoxin A fumarate
0 ImagesCat. No.: HY-N2326CAS No.: 1219922-30-1(±)-Anatoxin A fumarate is a natural alkaloid isolated from freshwater cyanobacterium.(±)-Anatoxin A fumarate is a potent nicotinic receptor agonist and exhibits Ki values of 1.25 nM and 1.84 μM for binding to α4β2- and α7-type nicotinic receptors in rat brain membranes, respectively. (±)-Anatoxin A fumarate stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50=134 nM). (±)-Anatoxin A fumarate has toxic effect on fish.
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Arecoline-d5 hydrobromide
0 ImagesArecoline-d5 hydrobromide is the deuterium labeled Arecoline hydrobromide (HY-B0489). Arecoline hydrobromide, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline hydrobromide exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrobromide also can induce oxidative stress.
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Tebanicline tosylate
0 ImagesSynonyms: Ebanicline tosylate; ABT-594 tosylateTebanicline tosylate, an analogue of epibatidine, is a neuronal nicotinic acetylcholine receptor agonist. Tebanicline tosylate exhibits potent antinociceptive effects and has a high affinity for the α4β2 neuronal nicotinic acetylcholine receptor subunit in the central nervous system.
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Epibatidine dihydrochloride
0 ImagesEpibatidine dihydrochloride serves as a powerful agonist for nicotinic receptors.
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Rivanicline
0 ImagesCat. No.: HY-13225ACAS No.: 15585-43-0Synonyms: RJR-2403; (E)-MetanicotineRivanicline (RJR-2403) is a neuronal nicotinic receptor agonist. Rivanicline is highly selective for the rat brain cortex nAChRs (Ki = 26 nM, EC50 of 732 nM) and α4β2 subtype (Ki = 26 nM, EC50 = 16 μM). Rivanicline can significantly restore the learning impairment and cognitive dysfunction. Rivanicline can be used for the study of neurodegenerative diseases (such as schizophrenia or Alzheimer's disease).
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Meclofenoxate hydrochloride (Standard)
0 ImagesSynonyms: Centrophenoxine hydrochloride (Standard)Meclofenoxate (hydrochloride) (Standard) is the analytical standard of Meclofenoxate (hydrochloride). This product is intended for research and analytical applications. Meclofenoxate hydrochloride is an ester synthesized from DMAE and pCPA, which has the activity of stimulating memory and improving cognition.
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Encenicline
0 ImagesCat. No.: HY-15430CAS No.: 550999-75-2Synonyms: EVP-6124Encenicline (EVP-6124) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).
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NS 9283 (Standard)
0 ImagesNS 9283 (Standard) is the analytical standard of NS 9283 (HY-110168). This product is intended for research and analytical applications. NS 9283 (A-969933) is a α4β2 nicotinic acetylcholine receptor (α4β2 nAChR) positive allosteric modulator that preferentially targets the (α4)3 (β2)2 stoichiometric conformation. NS 9283 increases the potency of ACh-induced currents without enhancing the maximal effect of ACh. NS 9283 also enhances prefrontal glutamate release, modulates attention-related electrophysiological responses, and potentiates the antinociceptive effects associated with α4β2 nAChR agonists. NS 9283 can be used in research related to inflammatory pain, postoperative pain, osteoarthritis pain, and Parkinson's disease.
