Reactive Oxygen Species (ROS)
Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.
ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.
All Product Categories
-
Reactive Oxygen Species (ROS) Inhibitors
(1091)
View all products
-
Reactive Oxygen Species (ROS) Agonists
(37)
View all products
-
Reactive Oxygen Species (ROS) Antagonists
(2)
View all products
-
Reactive Oxygen Species (ROS) Activators
(525)
View all products
-
Reactive Oxygen Species (ROS) Modulators
(22)
View all products
-
Reactive Oxygen Species (ROS) MDM2 Inhibitor
(1)
View all products
-
Reactive Oxygen Species (ROS) Inducers
(645)
View all products
-
Reactive Oxygen Species (ROS) Controls
(5)
View all products
-
Reactive Oxygen Species (ROS) Substrates
(3)
View all products
-
Reactive Oxygen Species (ROS) Related Products (2859)
Related Products (2859)
-
Antibodies (8)
-
Berberine
0 ImagesBerberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties. The sulfate form (HY-N0716B) improves bioavailability.
-
Keap1-Nrf2-IN-10
0 ImagesCat. No.: HY-147548CAS No.: 2445349-54-0Keap1-Nrf2-IN-10 (compound 15) is a potent NQO1 inducer. Keap1-Nrf2-IN-10 inhibits oxidative stress by decreasing the levels of MDA, ROS, NQO1 in the liver for gamma-irradiated mice. Keap1-Nrf2-IN-10 improves the survival of gamma-irradiated mice.
-
Keracyanin chloride (Standard)
0 ImagesCat. No.: HY-105935RCAS No.: 18719-76-1Synonyms: Cyanidin 3-rutinoside chloride (Standard); Cyanidin 3-O-rutinoside chloride (Standard); Sambucin chloride (Standard)Keracyanin (chloride) (Standard) is the analytical standard of Keracyanin (chloride). This product is intended for research and analytical applications. Keracyanin chloride inhibits NF-κB/FAK/MAPK signaling pathway. Keracyanin chloride exhibits antioxidant, anti-inflammatory and hypoglycemic effects, and is orally active.
-
α-Synuclein-IN-21
0 ImagesCat. No.: HY-184816CAS No.: 2883627-65-2α-Synuclein-IN-21 is an α-synuclein (α-Syn) aggregation inhibitor with an IC50 of 1.6 μM. α-Synuclein-IN-21 stabilizes the secondary conformation of α-synuclein monomers, inhibits β-sheet formation, reduces oligonucleation during the aggregation lag phase, dissociates preformed aggregates, and blocks re-aggregation. α-Synuclein-IN-21 reduces α-synuclein inclusions in neuronal cells and scavenges ROS. α-Synuclein-IN-21 can be used for the research of Parkinson's disease.
-
Parvifolixanthone A
0 ImagesCat. No.: HY-N8857CAS No.: 906794-56-7Parvifolixanthone A is a xanthone compound that can be isolated from Garcinia parvifolia. Parvifolixanthone A exhibits antioxidant activity with IC50 of submicromolar level (0.18–0.38 μM).
-
Dapsone-15N2
0 ImagesCat. No.: HY-B0688S3CAS No.: 287476-19-1Synonyms: 4,4′-Diaminodiphenyl sulfone-15N2; DDS-15N2Dapsone-15N2 (4,4′-Diaminodiphenyl sulfone-15N2) is 15N labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al.
-
Erioflorin
0 ImagesCat. No.: HY-187654CAS No.: 27542-17-2Erioflorin is a sesquiterpene lactone compound originally isolated from plants of the Asteraceae family (such as Eriophyllum confertiflorum and species of the Podanthus genus). Erioflorin acts as a selective β-TrCP1 modulator. Erioflorin induces cell apoptosis by increasing intracellular reactive oxygen species (ROS) production and decreasing mitochondrial membrane potential, inhibits the NF-κB signaling pathway by blocking the phosphorylation of IκBα, and prevents the ubiquitination and degradation of the tumor suppressor Pdcd4 by inhibiting the interaction between Pdcd4 and the E3 ubiquitin ligase β-TrCP1. Erioflorin can be used in research related to breast cancer, colon cancer, advanced prostate cancer, and Chagas disease.
-
N-acetyldopamine (Standard)
0 ImagesN-acetyldopamine is a sepiapterin reductase inhibitor. N-acetyldopamine is a catecholamine that is used by insects as sclerotizing precursors to harden their cuticle. N-acetyldopamine can attenuate LPS-stimulated TNF-α production and superoxide production in THP-1 cells.
-
8-(9-Bromoanthracene)-BODIPY 505/515
0 ImagesCat. No.: HY-D3449CAS No.: 2100893-80-78-(9-Bromoanthracene)-BODIPY 505/515 is a fluorescence turn-on probe with selective fluorescence turn-on response towards hydroxyl radical. 8-(9-Bromoanthracene)-BODIPY 505/515 can be used to detect reactive oxygen/nitrogen species (ROS/RNS). (Ex/Em = 505/515 nm)
-
1-Oleoyl-2-palmitoylglycerol
0 ImagesCat. No.: HY-W699318CAS No.: 3331-34-81-Oleoyl-2-palmitoylglycerol is a diacylglycerol in which an oleic acid and a palmitic acid are attached to sn-1 and sn-2 position. 1-Oleoyl-2-palmitoylglycerol enhances the inhibition of superoxide anion production induced by fMLF/cytochalasin B (CB) in human neutrophils. 1-Oleoyl-2-palmitoylglycerol can be used in research about lipid metabolism, membrane fluidity, or the distribution and function of lipids in cells.
-
Tamarixetin (Standard)
0 ImagesTamarixetin (Standard) is the analytical standard of Tamarixetin. This product is intended for research and analytical applications. Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p (ClpP) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of ClpP to the fluorescent substrate Suc-LY-AMC with an IC50 of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis, and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways.
-
Iberverin (Standard)
0 ImagesCat. No.: HY-121204RCAS No.: 505-79-3Synonyms: 3-Methylthiopropyl isothiocyanate (Standard)Iberverin (Standard) is the analytical standard of Iberverin. This product is intended for research and analytical applications. Iberverin (-Methylthiopropyl isothiocyanate) is a sulforaphane homolog. Iberverin has anticancer activity. Iberverin inhibits cell proliferation and migration. Iberverin induces mitochondrial-related apoptosis and intracellular reactive oxygen species[1].
-
Carazostatin
0 ImagesCat. No.: HY-119975CAS No.: 126168-32-9Synonyms: DC118Carazostatin (DC118), an antioxidant, can be isolated from Streptomycs chromofuscus. Carazostatin (DC118) exhibits strong inhibitory activity against free radical-induced lipid peroxidation and shows stronger antioxidant activity in liposomal membranes than α-tocopherol (VE).
-
Herbicidal agent 13
0 ImagesCat. No.: HY-179280Herbicidal agent 13 (Compound II-13) is a herbicidal agent. Herbicidal agent 13 retains the dual-target binding capabilities for PDS and ZDS, with Kd values of 71.8 μM and 0.586 mM against SynPDS and AtZDS, respectively. Herbicidal agent 13 increases ROS. Herbicidal agent 13 exhibits postemergence herbicidal activity against dicotyledonous weeds and monocotyledonous weed POLFU.
-
Dapsone (Standard)
0 ImagesSynonyms: 4,4′-Diaminodiphenyl sulfone (Standard); DDS (Standard)Dapsone (Standard) is the analytical standard of Dapsone. This product is intended for research and analytical applications. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al.
-
N-trans-Caffeoyltyramine (Standard)
0 ImagesCat. No.: HY-N8241RCAS No.: 103188-48-3N-trans-Caffeoyltyramine (Standard) is the analytical standard of N-trans-Caffeoyltyramine (HY-N8241). This product is intended for research and analytical applications. N-TRANS-CaffeoyLtyramine is an effective inflammatory response regulator, which has antioxidant activity and anticoagulation effects.
-
Sinapaldehyde (Standard)
0 ImagesSinapaldehyde is a methoxyphenol and a selective COX-2 inhibitor (IC50: 47.8 µM) that can be extracted from various plants. Sinapaldehyde has antibacterial, anti-inflammatory, and antioxidant activities. Sinapaldehyde can scavenge DPPH free radicals (IC50: 172 μM). Sinapaldehyde is active against both Gram-negative and Gram-positive bacteria.
-
Lanceolarin
0 ImagesCat. No.: HY-125670CAS No.: 15914-68-8Lanceolarin is an isoflavone compound isolated from the Andira inermis plant with anti-inflammatory, antioxidant and anti-tumor activities.
-
Norgestrel-d5
0 ImagesCat. No.: HY-N7137SCAS No.: 2015995-56-7
-
2,2-Dihydroxyacetic acid (Standard)
0 ImagesCat. No.: HY-W019724RCAS No.: 563-96-22,2-Dihydroxyacetic acid (Standard) is the analytical standard of 2,2-Dihydroxyacetic acid (HY-W019724). This product is intended for research and analytical applications. 2,2-Dihydroxyacetic acid is a key intermediate used in the synthesis of 3-aminocoumarone derivatives, which exhibit significant activity in chemiluminescence reactions and can be used for detecting hydrogen peroxide and evaluating urease activity .
