ABBV-467
Based on 1 Customer Validation
ABBV-467 is a selective MCL-1 inhibitor (Ki: <0.01 nM). ABBV-467 induces apoptosis. ABBV-467 induces cancer cell death and inhibits tumor growth in models of hematological malignancies, such as multiple myeloma.
For research use only. We do not sell to patients.
- Purity: 99.78%
- CAS No.: 2287186-66-5
- Formula: C53H51Cl2FN6O9S
- Molecular Weight:1037.98
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MCL-1[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| AMO1 | EC50 |
0.16 nM
Compound: ABBV-467
|
Antiproliferative activity against human AMO1 cells assessed as reduction in cell viability
Antiproliferative activity against human AMO1 cells assessed as reduction in cell viability
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[PMID: 38597264] |
| MV4-11 | EC50 |
3.91 nM
Compound: ABBV-467
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Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability
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[PMID: 38597264] |
| NCI-H929 | EC50 |
0.47 nM
Compound: ABBV-467
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Antiproliferative activity against human NCI-H929 cells assessed as reduction in cell viability
Antiproliferative activity against human NCI-H929 cells assessed as reduction in cell viability
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[PMID: 38597264] |
ABBV-467 (1 nM - 10 μM, 24 h) inhibits BAK protein expression in BAK-deficient SKBR3 cells[1]. ABBV-467 (0.01–10 nM, 24 hours) induces apoptosis in AMO-1 cell line[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BAK-deficient SKBR3 cells (breast cancer)
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Concentration:1 nM to 10 μM
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Incubation Time:24 h
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Result:Induced dose-dependent apoptosis after treatment.
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Cell Line:AMO-1 cell line (multiple myeloma)
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Concentration:1 nM to 10 μM
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Incubation Time:24 h
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Result:Resulted in a significant reduction in BAK protein expression.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:t(4;14) (chromosomal translocation between chromosome 4 and chromosome 14)-translocated high-risk multiple myeloma NOD-SCID mice[1]
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Dosage:6.25 mg/kg and 12.5 mg/kg
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Administration:Intravenous injection (i.v.), once per week for 3 weeks
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Result:Resulted in a maximal tumor delay of 82% at 6.25 mg/kg and complete tumor regression at 12.5 mg/kg.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2287186-66-5
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Appearance Solid
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Molecular Weight 1037.98
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Formula C53H51Cl2FN6O9S
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Color White to light yellow
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SMILES
O=C(O)[C@@H](CC1=CC2=CC=C1OCC3=NC(C4=CC=C(OC[C@H]5OCCOC5)C=C4)=NC=C3)OC6=NC=NC7=C6C(C8=C(C)C(Cl)=C(O[C@@H](CO2)CN9CCN(C)CC9)C(Cl)=C8C)=C(C%10=CC=C(F)C=C%10)S7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (96.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9634 mL | 4.8170 mL | 9.6341 mL | 24.0852 mL |
| 5 mM | 0.1927 mL | 0.9634 mL | 1.9268 mL | 4.8170 mL | |
| 10 mM | 0.0963 mL | 0.4817 mL | 0.9634 mL | 2.4085 mL | |
| 15 mM | 0.0642 mL | 0.3211 mL | 0.6423 mL | 1.6057 mL | |
| 20 mM | 0.0482 mL | 0.2409 mL | 0.4817 mL | 1.2043 mL | |
| 25 mM | 0.0385 mL | 0.1927 mL | 0.3854 mL | 0.9634 mL | |
| 30 mM | 0.0321 mL | 0.1606 mL | 0.3211 mL | 0.8028 mL | |
| 40 mM | 0.0241 mL | 0.1204 mL | 0.2409 mL | 0.6021 mL | |
| 50 mM | 0.0193 mL | 0.0963 mL | 0.1927 mL | 0.4817 mL | |
| 60 mM | 0.0161 mL | 0.0803 mL | 0.1606 mL | 0.4014 mL | |
| 80 mM | 0.0120 mL | 0.0602 mL | 0.1204 mL | 0.3011 mL |
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