ABC-1
ABC-1 is a phosphorylated analogue and a potential antiviral agent against Newcastle disease virus (NDV). ABC-1 has potent antiviral activity.
For research use only. We do not sell to patients.
- CAS No.: 309735-05-5
- Formula: C16H16N2OS
- Molecular Weight:284.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
ABC-1 (175 and 350 μM; 96 hours) potently inhibits Cytopathic effect (CPE) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:DF-1 cells
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Concentration:175 and 350 μM
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Incubation Time:96 hours
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Result:Inhibits Cytopathic effect (CPE).
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Chickens (NDV treated) [2]
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Dosage:2 mg/kg
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Administration:Oral
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Result:Reduced colocalized cells in liver and clara cells in lung tissue when compared to NDV control animals.
Chemical Information
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CAS No. 309735-05-5
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Molecular Weight 284.38
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Formula C16H16N2OS
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SMILES
CC1=CC=C(CSC2=NC3=CC=C(OC)C=C3N2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
References
[1]. K A S, et al. Design, Synthesis and Biological Evaluation of Novel Phosphorylated Abacavir Derivatives as Antiviral Agents Against Newcastle Disease Virus Infection in Chicken. Appl Biochem Biotechnol. 2016;180(2):361-381. [Content Brief]
[2]. Suresh KA, et al. Phosphorylated abacavir analogue (ABC-1) has ameliorative action against Newcastle disease virus induced pathogenesis in chicken. Biotechnol Appl Biochem. 2019;66(6):977-989. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ABC-1 Related Classifications
HY-124938 Related Classifications
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