Antiallergic agent-1
Antiallergic agent-1, a Src-family kinase inhibitor, may serve as a new valuable lead compound for future antiallergic agent discovery. Antiallergic agent-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- CAS No.: 2839159-12-3
- Formula: C27H19F6N5O
- Molecular Weight:543.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RBL-2H3 | CC50 |
377 nM
Compound: 36
|
Cytotoxicity against rat RBL2H3 cells assessed as cell viability incubated for 24 hrs by CCK-8 assay
Cytotoxicity against rat RBL2H3 cells assessed as cell viability incubated for 24 hrs by CCK-8 assay
|
[PMID: 34476950] |
| RBL-2H3 | IC50 |
9.32 nM
Compound: 36
|
Antiallergic activity against anti-DNP-IgE sensitized rat RBL-2H3 cells assessed as induction of degranulation by measuring beta-hexosaminidase release using P-nitrophenyl-N-acetyl-D-glucosamide as substrate measured after 1 hr by microplate reader
Antiallergic activity against anti-DNP-IgE sensitized rat RBL-2H3 cells assessed as induction of degranulation by measuring beta-hexosaminidase release using P-nitrophenyl-N-acetyl-D-glucosamide as substrate measured after 1 hr by microplate reader
|
[PMID: 34476950] |
Chemical Information
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CAS No. 2839159-12-3
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Molecular Weight 543.46
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Formula C27H19F6N5O
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SMILES
CN1N=CC(C2=CN=C(C(C#CC3=CC(C(NC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)=O)=CC=C3C)=C2)N)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)