Art. -Nr.: HY-N0591

Dehydrocostus Lactone

(Synonyms: (-)-Dehydrocostus lactone; Epiligulyl oxide)

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

Dehydrocostus Lactone ((-)-Dehydrocostus lactone) is a natural sesquiterpene that can be isolated from Saussurea lappa. Dehydrocostus Lactone has multiple activities such as anti-inflammatory, antibacterial, anti-tumor, and immunomodulatory effects. Dehydrocostus Lactone has an MIC of 2 µg/mL against Mycobacterium tuberculosis. Dehydrocostus Lactone can also inhibit the killing activity of cytotoxic T lymphocytes and induce apoptosis in tumor cells.

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Reinheit: 99.98%
CAS. Nr.: 477-43-0
Formel: C₁₅H₁₈O₂
Molecular Weight:230.30

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Dehydrocostus Lactone Chemical Structure

CAS. Nr.: 477-43-0

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle p38 MAPK Isoform-spezifische Produkte anzeigen :

Alle NF-κB Isoform-spezifische Produkte anzeigen :

Alle Akt Isoform-spezifische Produkte anzeigen :

Alle NO Synthase Isoform-spezifische Produkte anzeigen :

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

Alle Caspase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	10 μM Compound: 2	Inhibition of IL-1-beta-induced ICAM1 expression in human A549 cells Inhibition of IL-1-beta-induced ICAM1 expression in human A549 cells	[PMID: 9917276]
HL-60	IC₅₀	3.7 μM Compound: Dehydrocostus lactone	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 26832219]
HL-60	IC₅₀	5.3 μM Compound: 1	Cytotoxicity against human HL60 cells after 18 hrs by annexin-V labeling-based flow cytometry Cytotoxicity against human HL60 cells after 18 hrs by annexin-V labeling-based flow cytometry	[PMID: 22985027]
HL60/ADR	IC₅₀	5.1 μM Compound: Dehydrocostus lactone	Cytotoxicity against human HL60/ADR cells after 72 hrs by MTT assay Cytotoxicity against human HL60/ADR cells after 72 hrs by MTT assay	[PMID: 26832219]
K562	IC₅₀	5.3 μM Compound: Dehydrocostus lactone	Cytotoxicity against human K562 cells after 72 hrs by MTT assay Cytotoxicity against human K562 cells after 72 hrs by MTT assay	[PMID: 26832219]
K562/A02	IC₅₀	6.6 μM Compound: Dehydrocostus lactone	Cytotoxicity against human K562/A02 cells after 72 hrs by MTT assay Cytotoxicity against human K562/A02 cells after 72 hrs by MTT assay	[PMID: 26832219]
KG-1a	IC₅₀	10.5 μM Compound: Dehydrocostus lactone	Cytotoxicity against human KG1a cells after 72 hrs by MTT assay Cytotoxicity against human KG1a cells after 72 hrs by MTT assay	[PMID: 26832219]
Macrophage	IC₅₀	1.2 μg/mL Compound: 1	Antiinflammatory activity in mouse macrophages assessed as LPS-induced nitric oxide production Antiinflammatory activity in mouse macrophages assessed as LPS-induced nitric oxide production	10.1039/C2MD20172K
RAW264.7	IC₅₀	>40 μM Compound: DHCl	Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell viability by MTT assay relative to control Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell viability by MTT assay relative to control	[PMID: 39149113]
RAW264.7	IC₅₀	21.53 μM Compound: DHCl	Inhibition of LPS-induced NO production in mouse RAW264.7 cells preincubated for 2 hrs followed by LPS addition and measured after 24 hrs by Griess assay relative to control Inhibition of LPS-induced NO production in mouse RAW264.7 cells preincubated for 2 hrs followed by LPS addition and measured after 24 hrs by Griess assay relative to control	[PMID: 39149113]

In Vitro

Dehydrocostus lactone (0-2 mg/L; 48 h) can reduce the viability, induce apoptosis, inhibit the expression of anti-apoptotic proteins, and increase the expression of pro-apoptotic proteins in DU145 cells^[1].
Dehydrocostus lactone (0-30 μmol/L; 0.5-8.5 h) can inhibit the phosphorylation of p38 MAPK, MK2, and Akt, the activation of NF-κB, reduce the expression of iNOS and the production of NO, and decrease the mRNA levels of pro-inflammatory cytokines such as TNF-α, IL-6, IL-1β, and IL-12 in RAW264.7 cells treated with LPS (HY-D1056)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

DU145 human prostate cancer cells
Concentration:

2 mg/L
Incubation Time:

48 h
Result:

Decreased the level of anti-apoptotic protein Bcl-xL.
Increased the levels of pro-apoptotic proteins Bax, Bak, Bok, Bik, Bmf, and t-Bid.
Increased the levels of cleaved caspase-8, -9, -7, -3, and cleaved PARP.

Cell Viability Assay^[2]

Cell Line:

LPS (HY-D1056)-stimulated RAW264.7 cells.
Concentration:

0, 3, 5, 10 and 30 µmol/L
Incubation Time:

Pretreated with 0.5 h, then co-incubation with LPS (HY-D1056) for 0, 0.5, 1, 2, 4 and 8 h
Result:

Inhibited the protein expression levels of p-p38 MAPK, p-MK2, p-Akt.

In Vivo

Dehydrocostus Lactone (5-20 mg/kg; intraperitoneal injection; single administration) has a protective effect in a mouse model of LPS (HY-D1056)-induced acute lung injury^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 mice (male, 6-8 weeks old) treated LPS^[2]
Dosage:

5, 10 and 20 mg/kg
Administration:

Intraperitoneal injection (i.p.); single dose
Result:

Effectively reduced the LPS-stimulated infiltration of inflammatory cells and thickening of the alveolar walls.
Alleviated LPS-induced lung injury scores significantly.
Decreased the cell counts and total protein concentration in BALF.
Reduced the increased MPO activity induced by LPS challenge.
Significantly reduced the mRNA expression levels of iNOS, TNF-α, IL-6, IL-12 and IL-1β in lung tissues.

Chemical Information

CAS. Nr. 477-43-0
Appearance Solid
Molecular Weight 230.30
Formel C₁₅H₁₈O₂
Color White to off-white
SMILES

O=C(O[C@@]([C@@]1([H])C(CC[C@@]21[H])=C)([H])[C@@]3([H])CCC2=C)C3=C
Synonyms

(-)-Dehydrocostus lactone; Epiligulyl oxide
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (3)

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Journal Impact Factor

Phytother Res

Dehydrocostus Lactone Suppresses Hepatocellular Carcinoma by Inhibiting Protein Tyrosine Kinase-7 Mediated β-Catenin Signaling. [Abstract]

2026 Jun 5. PMID: 42248674
ACS Omega

Identification of New Modulators and Inhibitors of Palmitoyl-Protein Thioesterase 1 for CLN1 Batten Disease and Cancer. [Abstract]

2024 Feb 28;9(10):11870-11882. PMID: 38496939
Bioorg Chem

Dehydrocostus lactone promotes ferroptosis by regulating the HMOX1/CDK1 axis during liver cancer treatment. [Abstract]

2026 Jan:168:109349. PMID: 41389607

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 250 mg/mL (1085.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 15 mg/mL (65.13 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.3422 mL

21.7108 mL

43.4216 mL

5 mM

0.8684 mL

4.3422 mL

8.6843 mL

10 mM

0.4342 mL

2.1711 mL

4.3422 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (9.03 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (9.03 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (9.03 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (288 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Eun Ji Kim, et al. Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa. Food and Chemical Toxicology Volume 46, Issue 12, December 2008, Pages 3651–3658

[2]. Nie Y, Wang Z, Chai G, et al. Dehydrocostus Lactone Suppresses LPS-induced Acute Lung Injury and Macrophage Activation through NF-κB Signaling Pathway Mediated by p38 MAPK and Akt. Molecules. 2019;24(8):1510. [Content Brief]

[3]. Taniguchi M, et al. Costunolide and dehydrocostus lactone as inhibitors of killing function of cytotoxic T lymphocytes. Biosci Biotechnol Biochem. 1995 Nov;59(11):2064-7. [Content Brief]

[4]. Cantrell CL, et al. Antimycobacterial activities of dehydrocostus lactone and its oxidation products. J Nat Prod. 1998 Oct;61(10):1181-6. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Ethanol / DMSO	1 mM	4.3422 mL	21.7108 mL	43.4216 mL	108.5541 mL
	5 mM	0.8684 mL	4.3422 mL	8.6843 mL	21.7108 mL
	10 mM	0.4342 mL	2.1711 mL	4.3422 mL	10.8554 mL
	15 mM	0.2895 mL	1.4474 mL	2.8948 mL	7.2369 mL
	20 mM	0.2171 mL	1.0855 mL	2.1711 mL	5.4277 mL
	25 mM	0.1737 mL	0.8684 mL	1.7369 mL	4.3422 mL
	30 mM	0.1447 mL	0.7237 mL	1.4474 mL	3.6185 mL
	40 mM	0.1086 mL	0.5428 mL	1.0855 mL	2.7139 mL
	50 mM	0.0868 mL	0.4342 mL	0.8684 mL	2.1711 mL
	60 mM	0.0724 mL	0.3618 mL	0.7237 mL	1.8092 mL
DMSO	80 mM	0.0543 mL	0.2714 mL	0.5428 mL	1.3569 mL
DMSO	100 mM	0.0434 mL	0.2171 mL	0.4342 mL	1.0855 mL

Keywords

Dehydrocostus Lactone

3 Cited Publications

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Dehydrocostus Lactone

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