Art. -Nr.: HY-B1125

Glucosamine

(Synonyms: D-Glucosamine; Chitosamine)

12 Cited Publications

Kundenbewertung

Based on 12 publication(s) in Google Scholar

Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes.

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Reinheit: 98.0%
CAS. Nr.: 3416-24-8
Formel: C₆H₁₃NO₅
Molecular Weight:179.17

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Glucosamine Chemical Structure

CAS. Nr.: 3416-24-8

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Use of MCE Products

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Clinical Trial
Chemical Information
Publications (12)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Human Endogenous Metabolite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

Alle HIF/HIF Prolyl-Hydroxylase Isoform-spezifische Produkte anzeigen :

In Vitro

Glucosamine (D-Glucosamine) exhibits dose-dependent DPPH antioxidant activity^[2].
Glucosamine treatment of Short-term (4 h) inhibits HIF-1α at the protein level, decreases phosphorylation of p70S6K and S6, translation-related proteins^[3].
Glucosamine significantly decreases renal expression of α-smooth muscle actin, collagen I, and fibronectin in the obstructed kidneys and TGF-β1-treated renal cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 3416-24-8
Appearance Solid
Molecular Weight 179.17
Formel C₆H₁₃NO₅
Color White to off-white
SMILES

O=C[C@H](N)[C@H]([C@@H]([C@@H](CO)O)O)O
Synonyms

D-Glucosamine; Chitosamine
Structure Classification
- Saccharides
- Monosaccharides
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
- Microorganisms
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (12)

All Cell Proliferation/Viability AssayBio/Physico-chemical AssayWB

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Mil Med Res

Accelerating cartilage regeneration with DNA-SF hydrogel sustained release system-based cartilage organoids. [Abstract]

2025 Jul 28;12(1):39. PMID: 40722047
Theranostics

Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma. [Abstract]

2021 Mar 24;11(12):5650-5674. PMID: 33897873

Glucosamine purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Mar 24;11(12):5650-5674. [Abstract]

LUAD cells were treated with erastin with or without Fer-1 or DFO, in the presence or absence of GlcN (5 mM). Cell death was measured after treatment for 24 h.

Glucosamine purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Mar 24;11(12):5650-5674. [Abstract]

LUAD cells were treated with erastin with or without Fer-1 or DFO, in the presence or absence of GlcN (5 mM). MDA was measured after treatment for 16 h.

Glucosamine purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Mar 24;11(12):5650-5674. [Abstract]

Metabolites downstream of GFPT1 restore YAP alteration by erastin. p-YAP^S127, O-YAP^T241 and YAP were measured by IB in H1975 cells treated with or without erastin, glucose, GlcN (5 mM) or GlcNAc for 8 h.
Microbiome

Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites. [Abstract]

2019 Mar 20;7(1):43. PMID: 30890187
Cell Rep

The hexosamine biosynthetic pathway drives tumor immune evasion via translational control of PD-L1 at the elongation level. [Abstract]

2025 Sep 10;44(9):116249. PMID: 40938752
Int Immunopharmacol

Enhancing GFPT1 expression with glutamine protects chondrocytes in osteoarthritis. [Abstract]

2024 Oct 18;143(Pt 2):113427. PMID: 39426230
Artif Cells Nanomed Biotechnol

Characterization of genipin-crosslinked gelatin/PVA hydrogels and the chondroprotective influence of hydroxytyrosol: an In vitro study. [Abstract]

2026 Dec;54(1):248-275. PMID: 42331338
Am J Physiol Gastrointest Liver Physiol

Glucose metabolism through the hexosamine biosynthetic pathway drives hepatic de novo lipogenesis via promoting N-linked protein glycosylation. [Abstract]

2025 Jun 1;328(6):G746-G759. PMID: 40331866
Diabetes Metab Syndr Obes

Establishment and Evaluation of HepG2 Cell Insulin Resistance Model. [Abstract]

2025 Jul 29:18:2573-2584. PMID: 40755745
Biocell

2025 Sep 25;49(9):1711-1731.
bioRxiv

2026 Jan 26.
Laurea Magistrale in Biomedical Engineering, Politecnico di Milano

2019 Jun.

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 100 mg/mL (558.12 mM; ultrasonic and warming and heat to 60°C)

DMSO : 3.33 mg/mL (18.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.5812 mL

27.9061 mL

55.8123 mL

5 mM

1.1162 mL

5.5812 mL

11.1625 mL

10 mM

0.5581 mL

2.7906 mL

5.5812 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 50 mg/mL (279.06 mM); Clear solution; Need ultrasonic

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Bruyère O, et al. Efficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016 Feb;45(4 Suppl):S12-7. [Content Brief]

[2]. Jamialahmadi K, et al. Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage. Environ Toxicol Pharmacol. 2014 Jul;38(1):212-9. [Content Brief]

[3]. Jo JR, et al. Short-term treatment with glucosamine hydrochloride specifically downregulates hypoxia-inducible factor-1α at the protein level in YD-8 human tongue cancer cells. Int J Oncol. 2014 May;44(5):1699-706. [Content Brief]

[4]. Park J, et al. Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling. J Mol Med (Berl). 2013 Nov;91(11):1273-84. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	5.5812 mL	27.9061 mL	55.8123 mL	139.5307 mL
	5 mM	1.1162 mL	5.5812 mL	11.1625 mL	27.9061 mL
	10 mM	0.5581 mL	2.7906 mL	5.5812 mL	13.9531 mL
	15 mM	0.3721 mL	1.8604 mL	3.7208 mL	9.3020 mL
H₂O	20 mM	0.2791 mL	1.3953 mL	2.7906 mL	6.9765 mL
	25 mM	0.2232 mL	1.1162 mL	2.2325 mL	5.5812 mL
	30 mM	0.1860 mL	0.9302 mL	1.8604 mL	4.6510 mL
	40 mM	0.1395 mL	0.6977 mL	1.3953 mL	3.4883 mL
	50 mM	0.1116 mL	0.5581 mL	1.1162 mL	2.7906 mL
	60 mM	0.0930 mL	0.4651 mL	0.9302 mL	2.3255 mL
	80 mM	0.0698 mL	0.3488 mL	0.6977 mL	1.7441 mL
	100 mM	0.0558 mL	0.2791 mL	0.5581 mL	1.3953 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Glucosamine

12 Cited Publications

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Glucosamine

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Publications Citing Use of MedChemExpress (MCE) Glucosamine

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Alle HIF/HIF Prolyl-Hydroxylase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (12)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs