Art. -Nr.: HY-113099

Indolelactic acid

(Synonyms: Indole-3-lactic acid)

14 Cited Publications

Kundenbewertung

Based on 14 publication(s) in Google Scholar

Indolelactic acid (Indole-3-lactic acid) is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures. Indolelactic acid has anti-inflammation and potential anti-viral activity.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.95%
CAS. Nr.: 1821-52-9
Formel: C₁₁H₁₁NO₃
Molecular Weight:205.21

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months

Indolelactic acid Chemical Structure

CAS. Nr.: 1821-52-9

Größe

Preis

Verfügbarkeit

Menge

Sample (0.1mg)

In-stock

(In Japan)

Apply Now

Angebot einholen Ask For Quote & Lead Time Consult sales personnel for more information Check price and availability Angebot einholen Ask For Quote & Lead Time Consult sales personnel for more information Check price and availability

Massenanfrage

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (14)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

Indolelactic acid (Indole-3-lactic acid) is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures. Indolelactic acid has anti-inflammation and potential anti-viral activity^[1]^[3]^[4].

IC₅₀ & Target

Human Endogenous Metabolite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	0.22 mM Compound: DL-indole-3-lactic acid	Inhibition of human recombinant KAT1 expressed in Sf9 cells Inhibition of human recombinant KAT1 expressed in Sf9 cells	[PMID: 19338303]

In Vitro

Indolelactic acid (1 mM, 5 days) upregulates CXCR3, granzyme B, and immunoregulatory galectin-1 in Th2 cells^[2].
Indolelactic acid (0.1-10 mM, 1 h) significantly inhibits LPS-induced inflammation in RAW blue macrophages and Caco-2 cells^[3].
Indolelactic acid (0.1-10 mM, 1 h) inhibits TNF-α induced inflammation in HT-29 cells^[3].
Indolelactic acid (10 mM, 1 h) activates the AhR and downstream Nrf2 pathway in Caco-2 cells^[3].
Indolelactic acid (5 μM, 24 h) enhances the IFIT2 and RSAD2 mRNA expression in H4 cells stimulated by IL-1β^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[3]

Cell Line:

HT-29 cells
Concentration:

0.1, 1, 10 mM
Incubation Time:

1 h
Result:

Decreased IL-8 level induced by TNF-α, and increased β-defensin 2 and SERT level.

In Vivo

Indolelactic acid (gavage feeding, 10 μM, 5 μL, 5 days, C57BL/6 mice) benefits the immature intestine preferentially^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 mice^[4]
Dosage:

10 μM, 5 μL
Administration:

Gavage feeding, 5 days
Result:

Upregulated the innate immune response genes in immature mouse intestine (C57-pup-ileum), with no effects on pup-colon or adult intestine.

Chemical Information

CAS. Nr. 1821-52-9
Appearance Solid
Molecular Weight 205.21
Formel C₁₁H₁₁NO₃
Color Off-white to light yellow
SMILES

OC(C(CC1=CNC2=CC=CC=C12)O)=O
Synonyms

Indole-3-lactic acid
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	1 year
	-20°C	6 months

Publications (14)

All Cell Proliferation/Viability AssayIn Vivo Efficacy StudyFlow CytometryRT-PCRWB

Sort by:

Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Imeta

Black rice diet alleviates colorectal cancer development through modulating tryptophan metabolism and activating AHR pathway. [Abstract]

2024 Jan 15;3(1):e165. PMID: 38868519

Indolelactic acid purchased from MedChemExpress. Usage Cited in: Imeta. 2024 Jan 15;3(1):e165. [Abstract]

Cell growth curves of colorectal cancer (CRC) cell line HCT116 cells treated with Indolelactic acid (2 μM; 2 days) and a vehicle (as negative control).

Indolelactic acid purchased from MedChemExpress. Usage Cited in: Imeta. 2024 Jan 15;3(1):e165. [Abstract]

HCT116 cells treated with or without Indolelactic acid (2 μM; 12 h) were stained with propidium iodide (PI) and analyzed using flow cytometry.

Indolelactic acid purchased from MedChemExpress. Usage Cited in: Imeta. 2024 Jan 15;3(1):e165. [Abstract]

Expression levels of cell proliferation and cell cycle-associated proteins and gut barrier function-associated proteins in HCT116 cells treated with or without Indolelactic acid (2 μM; 12 h).
Nat Immunol

Microbiota-shaped neutrophil senescence regulates sexual dimorphism in bladder cancer. [Abstract]

2025 Apr 11. PMID: 40217111
Adv Sci (Weinh)

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR-Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma. [Abstract]

2025 Dec 22:e13606. PMID: 41431173
Theranostics

Bifidobacterium breve-derived indole-3-lactic acid ameliorates colitis-associated tumorigenesis by directing the differentiation of immature colonic macrophages. [Abstract]

2024 Apr 22;14(7):2719-2735. PMID: 38773969

Indolelactic acid purchased from MedChemExpress. Usage Cited in: Theranostics. 2024 Apr 22;14(7):2719-2735. [Abstract]

Colitis-associated colorectal cancer (CAC) mice treate PBS, Indolelactic acid (ILA) (20 mg/kg/daily by oral gavage) and ILA+CH-223191. Representative colonic images and statistical histogram of colon length.

Indolelactic acid purchased from MedChemExpress. Usage Cited in: Theranostics. 2024 Apr 22;14(7):2719-2735. [Abstract]

Gene expression of Il1b, Tnf, and Il10 in murine BMDMs treated Indolelactic acid (ILA) (0-1000 μM) and ILA+CH-223191.
Int J Oral Sci

Periodontitis-associated salivary microbiota exacerbates systemic osteoclastogenesis via gut modulation and tryptophan metabolism suppression in ovariectomized mice. [Abstract]

2026 Jan 27;18(1):14. PMID: 41587982
Gut Microbes

Indole-3-lactic acid suppresses colorectal cancer via metabolic reprogramming. [Abstract]

2025 Dec;17(1):2508949. PMID: 40409349
Cell Rep

Bifidobacterium animalis suppresses non-small cell lung cancer progression and modulates tumor immunity through indole-3-acetic acid. [Abstract]

2025 Aug 12;44(8):116132. PMID: 40802513
J Agric Food Chem

Tryptophan-Rich Diet Improves High-Fat Diet-Induced Cognitive Dysfunction and Blood-Brain Barrier Disruption in C57BL/6 Mice through FFAR3 Activation. [Abstract]

2025 Jul 16;73(28):17696-17712. PMID: 40600293
Psoriasis (Auckl)

Indole-3-Lactic Acid Attenuates IMQ-Induced Psoriasiform Dermatitis in Mice via AhR-Dependent Suppression of IL-17A. [Abstract]

2026 Mar 27:16:585731. PMID: 41918778
Cell Prolif

Tryptophan Metabolic Enzyme IL4I1 Inhibits Ferroptosis by Decreasing Ubiquitination of Nrf2 via I3P in Glioblastoma. [Abstract]

2025 Jun;58(6):e13816. PMID: 40071723
Int J Mol Sci

Cinnamic Acid, Perillic Acid, and Tryptophan Metabolites Differentially Regulate Ion Transport and Serotonin Metabolism and Signaling in the Mouse Ileum In Vitro. [Abstract]

2024 Jun 18;25(12):6694. PMID: 38928404
Amino Acids

Tryptophan regulates bile and nitrogen metabolism in two pig gut lactobacilli species in vitro based on metabolomics study. [Abstract]

2022 Oct;54(10):1421-1435. PMID: 35838843
Authorea

2026 Mar 31.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (487.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.8730 mL

24.3649 mL

48.7299 mL

5 mM

0.9746 mL

4.8730 mL

9.7460 mL

10 mM

0.4873 mL

2.4365 mL

4.8730 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (10.14 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (10.14 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 1.98 mg/mL (9.65 mM); Clear solution

This protocol yields a clear solution of ≥ 1.98 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (19.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 0.5% CMC-Na/saline water

Solubility: 20 mg/mL (97.46 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Francisco García-Tabares, et al. Production of 3-indoleacetic acid and 3-indolelactic acid in Azotobacter vinelandii cultures supplemented with tryptophan. Appl Microbiol Biotechnol.1987 Mar, 25 (6):502–506.

[2]. Bethany M Henrick, et al. Bifidobacteria-mediated immune system imprinting early in life. Cell. 2021 Jul 22;184(15):3884-3898.e11. [Content Brief]

[3]. Amy M Ehrlich, et al. Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells. BMC Microbiol. 2020 Nov 23;20(1):357. [Content Brief]

[4]. Wuyang Huang, et al. The impact of indole-3-lactic acid on immature intestinal innate immunity and development: a transcriptomic analysis. Sci Rep. 2021 Apr 13;11(1):8088. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.8730 mL	24.3649 mL	48.7299 mL	121.8246 mL
	5 mM	0.9746 mL	4.8730 mL	9.7460 mL	24.3649 mL
	10 mM	0.4873 mL	2.4365 mL	4.8730 mL	12.1825 mL
	15 mM	0.3249 mL	1.6243 mL	3.2487 mL	8.1216 mL
	20 mM	0.2436 mL	1.2182 mL	2.4365 mL	6.0912 mL
	25 mM	0.1949 mL	0.9746 mL	1.9492 mL	4.8730 mL
	30 mM	0.1624 mL	0.8122 mL	1.6243 mL	4.0608 mL
	40 mM	0.1218 mL	0.6091 mL	1.2182 mL	3.0456 mL
	50 mM	0.0975 mL	0.4873 mL	0.9746 mL	2.4365 mL
	60 mM	0.0812 mL	0.4061 mL	0.8122 mL	2.0304 mL
	80 mM	0.0609 mL	0.3046 mL	0.6091 mL	1.5228 mL
	100 mM	0.0487 mL	0.2436 mL	0.4873 mL	1.2182 mL

Keywords

Indolelactic acid

14 Cited Publications

100 mg Angebot einholen

Subscribe to the

MedChemExpress

Newsletter

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Indolelactic acid

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Natural Product Library

Human Endogenous Metabolite Compound Library

Pyroptosis Compound Library

Orally Active Compound Library

Gut Microbial Metabolite Library

Microbial Metabolite Library

Food-Sourced Compound Library

Human Metabolite Library

Animal-Sourced Natural Product Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Endogenous Metabolite Library

Mass Spectrometry Human Metabolite Library

Plant Hormone Library

Mass Spectrometry Natural Product Library

3D Diverse Fragment Library

Publications Citing Use of MedChemExpress (MCE) Indolelactic acid

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (14)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Indolelactic acid

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Natural Product Library

Human Endogenous Metabolite Compound Library

Pyroptosis Compound Library

Orally Active Compound Library

Gut Microbial Metabolite Library

Microbial Metabolite Library

Food-Sourced Compound Library

Human Metabolite Library

Animal-Sourced Natural Product Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Endogenous Metabolite Library

Mass Spectrometry Human Metabolite Library

Plant Hormone Library

Mass Spectrometry Natural Product Library

3D Diverse Fragment Library

Publications Citing Use of MedChemExpress (MCE) Indolelactic acid

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (14)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Indolelactic acid Related Classifications

Art. -Nr.: HY-113099