Art. -Nr.: HY-12506

Naspm

Name: Naspm
Brand: MedChemExpress
SKU: HY-12506
Price: 96.00 USD
Availability: InStock
Rating: 5 (9 reviews)

(Synonyms: 1-Naphthylacetyl spermine)

9 Cited Publications

Kundenbewertung

Based on 9 publication(s) in Google Scholar

Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 95.15%
CAS. Nr.: 122306-11-0
Formel: C₂₂H₃₄N₄O
Molecular Weight:370.53

Speicherung:

Pure form -20°C, 3 years ; In solvent -80°C, 2 years , -20°C, 1 year

Naspm Chemical Structure

CAS. Nr.: 122306-11-0

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Publications (9)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

Alle iGluR Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Oocyte	IC₅₀	0.69 μM Compound: 2	Antagonist activity for [Ca2+] permeable Ionotropic glutamate receptor AMPA expressed in Xenopus oocytes by injection of rat brain mRNA Antagonist activity for [Ca2+] permeable Ionotropic glutamate receptor AMPA expressed in Xenopus oocytes by injection of rat brain mRNA	[PMID: 11392532]
Oocyte	IC₅₀	0.69 μM Compound: 2-NAS	Antagonistic activity against Ca++permeable Ionotropic glutamate receptor AMPA as concentration of compound that reduces the inward current induced by kainate by 50% in Xenopus oocytes Antagonistic activity against Ca++permeable Ionotropic glutamate receptor AMPA as concentration of compound that reduces the inward current induced by kainate by 50% in Xenopus oocytes	[PMID: 11551773]

In Vitro

NASPM selectively suppresses the inwardly rectifying and Ca²⁺-permeable AMPA receptors expressed in type II neurons. It has no effect on AMPA receptors in type I neurons. At -60 mV, NASPM suppresses AMPA receptors in type II neurons with an IC₅₀ value of 0.33 μM. The blocking effect of NASPM on the Ca²⁺-permeable AMPA receptors is use and voltage-dependent^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 122306-11-0
Appearance Liquid (Density: 1.062 g/cm³)
Molecular Weight 370.53
Formel C₂₂H₃₄N₄O
Color Colorless to light yellow
SMILES

O=C(NCCCNCCCCNCCCN)CC1=C2C=CC=CC2=CC=C1
Synonyms

1-Naphthylacetyl spermine
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Pure form	-20°C	3 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (9)

All IF

Sort by:

Journal Impact Factor

Adv Sci (Weinh)

2026 Sep;13(52):e76298. PMID: 42523036
J Headache Pain

Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine. [Abstract]

2022 Aug 10;23(1):98. PMID: 35948867
Cell Rep

Single-cell RNA sequencing uncovers the cell type-dependent transcriptomic changes in the retrosplenial cortex after peripheral nerve injury. [Abstract]

2023 Dec 3;42(12):113551. PMID: 38048224
Cell Rep

Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity. [Abstract]

2020 Nov 10;33(6):108369. PMID: 33176141
Neurobiol Dis

Spinal nerve transection-induced upregulation of SAP97 via promoting membrane trafficking of GluA1-containing AMPA receptors in the dorsal horn contributes to the pathogenesis of neuropathic pain. [Abstract]

2024 May:194:106471. PMID: 38461868
iScience

Synaptic scaling of corticostriatal circuits underlies hyperactivity in GABA Transporter-1 deficient mice. [Abstract]

2023 Mar 3;26(4):106322. PMID: 36968092
Neuroscience

The Control of Rat Hippocampal Gamma Oscillation Strength by BK Channel Activity. [Abstract]

2021 Nov 1:475:220-228. PMID: 34509547
Brain Res

Upregulation of synapse-associated protein 97 in the spinal dorsal horn exacerbates inflammatory pain through mediating GluA1-containing AMPARs membrane trafficking. [Abstract]

2026 Jul 15:1883:150291. PMID: 41916464
Toxicol In Vitro

Propofol inhibits invasion and proliferation of C6 glioma cells by regulating the Ca2+ permeable AMPA receptor-system xc- pathway. [Abstract]

2017 Oct:44:57-65. PMID: 28663055

Naspm purchased from MedChemExpress. Usage Cited in: Toxicol In Vitro. 2017 Oct:44:57-65. [Abstract]

A Transwell invasion assay of cells is used to measure invasiveness after treatment with L-glutamate, propofol, 1-Naphthyl acetyl spermine (NAS), or (R, S)-AMPA.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (269.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.6988 mL

13.4942 mL

26.9884 mL

5 mM

0.5398 mL

2.6988 mL

5.3977 mL

10 mM

0.2699 mL

1.3494 mL

2.6988 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.5 mg/mL (6.75 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (6.75 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: 2.5 mg/mL (6.75 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29(1):27-36. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.6988 mL	13.4942 mL	26.9884 mL	67.4709 mL
	5 mM	0.5398 mL	2.6988 mL	5.3977 mL	13.4942 mL
	10 mM	0.2699 mL	1.3494 mL	2.6988 mL	6.7471 mL
	15 mM	0.1799 mL	0.8996 mL	1.7992 mL	4.4981 mL
	20 mM	0.1349 mL	0.6747 mL	1.3494 mL	3.3735 mL
	25 mM	0.1080 mL	0.5398 mL	1.0795 mL	2.6988 mL
	30 mM	0.0900 mL	0.4498 mL	0.8996 mL	2.2490 mL
	40 mM	0.0675 mL	0.3374 mL	0.6747 mL	1.6868 mL
	50 mM	0.0540 mL	0.2699 mL	0.5398 mL	1.3494 mL
	60 mM	0.0450 mL	0.2249 mL	0.4498 mL	1.1245 mL
	80 mM	0.0337 mL	0.1687 mL	0.3374 mL	0.8434 mL
	100 mM	0.0270 mL	0.1349 mL	0.2699 mL	0.6747 mL

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Naspm

Publications Citing Use of MedChemExpress (MCE) Naspm

Alle iGluR Isoform-spezifische Produkte anzeigen