Nortadalafil
Based on 1 publication(s) in Google Scholar
Nortadalafil (Demethyl Tadalafil) is a phosphodiesterase-5 (PDE-5) inhibitor and Tadalafil (HY-90009A) analog. Nortadalafil exhibits pharmacokinetic properties including a half-life of 5.93-6.21 h after single oral doses of 40-120 mg.Nortadalafil is identified as an adulterant in dietary supplements.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.65%
- CAS. Nr.: 171596-36-4
- Formel: C21H17N3O4
- Molecular Weight:375.38
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
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Publications Citing Use of MedChemExpress (MCE) Nortadalafil
More
Biologische Aktivität
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PDE5 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MRC5 | IC50 |
>64 μM
Compound: 6, nortadalafil
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Cytotoxicity against human MRC5 SV2 cells after 72 hrs
Cytotoxicity against human MRC5 SV2 cells after 72 hrs
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[PMID: 21504142] |
Nortadalafil (1000 µg/mL (reference standard); 30 min (sonication)) isolated from the adulterated health supplement at retention time 22.7 min via HPLC is confirmed to be Nortadalafil through matching retention times, UV spectra, mass spectrometry, and NMR data relative to the Nortadalafil reference standard[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 171596-36-4
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Appearance Solid
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Molecular Weight 375.38
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Formel C21H17N3O4
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Color White to off-white
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SMILES
O=C1NCC(N([C@@H]1C2)[C@H](C3=CC=C(OCO4)C4=C3)C5=C2C6=C(N5)C=CC=C6)=O
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Synonyms
Demethyl Tadalafil
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Breast Cancer Res
Modulating phosphodiesterase-5 activity to suppress the immunosuppressive mechanisms of myeloid-derived suppressor cells in breast cancer. [Abstract]2025 Oct 23;27(1):184. PMID: 41131545
Lösungsmittel & Löslichkeit
DMSO : 50 mg/mL (133.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.66 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (282 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6640 mL | 13.3198 mL | 26.6397 mL | 66.5992 mL |
| 5 mM | 0.5328 mL | 2.6640 mL | 5.3279 mL | 13.3198 mL | |
| 10 mM | 0.2664 mL | 1.3320 mL | 2.6640 mL | 6.6599 mL | |
| 15 mM | 0.1776 mL | 0.8880 mL | 1.7760 mL | 4.4399 mL | |
| 20 mM | 0.1332 mL | 0.6660 mL | 1.3320 mL | 3.3300 mL | |
| 25 mM | 0.1066 mL | 0.5328 mL | 1.0656 mL | 2.6640 mL | |
| 30 mM | 0.0888 mL | 0.4440 mL | 0.8880 mL | 2.2200 mL | |
| 40 mM | 0.0666 mL | 0.3330 mL | 0.6660 mL | 1.6650 mL | |
| 50 mM | 0.0533 mL | 0.2664 mL | 0.5328 mL | 1.3320 mL | |
| 60 mM | 0.0444 mL | 0.2220 mL | 0.4440 mL | 1.1100 mL | |
| 80 mM | 0.0333 mL | 0.1665 mL | 0.3330 mL | 0.8325 mL | |
| 100 mM | 0.0266 mL | 0.1332 mL | 0.2664 mL | 0.6660 mL |
Nortadalafil Related Classifications
HY-90009 Related Classifications
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