1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Tadalafil-d3

Tadalafil-d3 (Synonyms: IC-351-d3)

Cat. No.: HY-90009S
Handling Instructions

Tadalafil-d3 (IC-351-d3) is the deuterium labeled Nortadalafil. Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.

For research use only. We do not sell to patients.

Tadalafil-d3 Chemical Structure

Tadalafil-d3 Chemical Structure

CAS No. : 960226-55-5

Size Price Stock Quantity
1 mg USD 220 In-stock
Estimated Time of Arrival: December 31
5 mg USD 630 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1050 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Tadalafil-d3 (IC-351-d3) is the deuterium labeled Nortadalafil. Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

392.42

Formula

C22H16D3N3O4

CAS No.
SMILES

O=C1N2[[email protected]@](C3=CC=C(OCO4)C4=C3)([H])C5=C(C[[email protected]]2([H])C(N(C1)C([2H])([2H])[2H])=O)C6=CC=CC=C6N5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
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