Butaprost
Based on 2 publication(s) in Google Scholar
Butaprost is a selective prostaglandin E receptor (EP2) agonist with an EC50 of 33 nM and a Ki of 2.4 μM for murine EP2 receptor. Butaprost is less activity against murine EP1, EP3 and EP4 receptors. Butaprost attenuates fibrosis by hampering TGF-β/Smad2 signalling.
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- Reinheit: 99.85%
- CAS. Nr.: 69685-22-9
- Formel: C24H40O5
- Molecular Weight:408.57
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Speicherung:
Solution, -20°C, 2 years
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Butaprost
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Biologische Aktivität
Butaprost (1-100 nM; 0.5-24 hours) induces about a five-fold upregulation of Nur77 mRNA expression in hEP2-HEK293/EBNA cells in a dose- and time-dependent. Butaprost upregulated Nur77 gene expression through the PKC pathway[1].
Butaprost (50 μM; 24 hours) reduces TGF-β-induced fibronectin (FN) expression, Smad2 phosphorylation and epithelial-mesenchymal transition in Madin-Darby Canine Kidney (MDCK) cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK 293/EBNA cells stably expressing the human EP2 receptor (hEP2-HEK 293/EBNA cells)
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Concentration:1 nM, 10 nM, 100 nM
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Incubation Time:0.5 hours, 1 hours, 6 hours, 24 hours
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Result:Induced about a five-fold upregulation of Nur77 mRNA expression in hEP2-HEK293/EBNA cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6 mice (8 weeks of age; 21 g) bearing unilateral ureteral obstruction surgery[2]
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Dosage:1 mg/kg, 2 mg/kg, 4 mg/kg
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Administration:Intraperitoneal injection; twice daily; for 7 days
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Result:Attenuated the development of fibrosis in mice that underwent unilateral ureteral obstruction surgery.
Chemical Information
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CAS. Nr. 69685-22-9
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Appearance Liquid
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Molecular Weight 408.57
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Formel C24H40O5
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Color Colorless to light yellow
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SMILES
COC(CCCCCC[C@@H](C(C[C@H]1O)=O)[C@H]1/C=C/C[C@@H](C2(CCC2)CCC)O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Solution, -20°C, 2 years
Publications (2)
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Journal Impact Factor
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Most Recent
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J Neuroinflammation
Taprenepag restores maternal-fetal interface homeostasis for the treatment of neurodevelopmental disorders. [Abstract]2024 Nov 28;21(1):307. PMID: 39609821 -
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Yanbin Liang, et al. Upregulation of orphan nuclear receptor Nur77 following PGF(2alpha), Bimatoprost, and Butaprost treatments. Essential role of a protein kinase C pathway involved in EP(2) receptor activated Nur77 gene transcription. Br J Pharmacol. 2004 Jun;142(4):737-48. [Content Brief]
[2]. Michael Schou Jensen, et al. Activation of the prostaglandin E 2 EP 2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices. Acta Physiol (Oxf). 2019 Sep;227(1):e13291. [Content Brief]
[3]. K Tani, et al. Design and synthesis of a highly selective EP2-receptor agonist. Bioorg Med Chem Lett. 2001 Aug 6;11(15):2025-8. [Content Brief]
Calculators
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