Cardiogenol C
Cardiogenol C is a potent cell-permeable pyrimidine inducer which prompts the differentiation of ESCs into cardiomyocytes (EC50=100 nM). Cardiogenol C also acts cardiomyogenic on already lineage-committed progenitor cell types with a limited degree of plasticity. Cardiogenol C is a useful cardiomyogenic agent and can be used as a tool to improve cardiac repair by cell transplantation therapy in animal models.
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- CAS. Nr.: 671225-39-1
- Formel: C13H16N4O2
- Molecular Weight:260.29
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Cardiogenol C hydrochlorideCardiomyogenic Agent
Biologische Aktivität
Beschreibung
IC50 & Target
EC50: 100 nM (differentiation of ESCs into cardiomyocytes)[1]
In Vitro
Cardiogenol C (1 μM; 7 days) has a cardiomyogenic effect on P19 cells, it significantly increases atrial natriuretic factor (ANF, nppa) in P19 cells when it compares to untreated control cells[1].Cardiogenol C (0.01-100 μM; 7 days) significantly increases ANF expression. In addition, another frequently used cardiac marker gene (NKX2-5) is also significantly increased by this small molecule in C2C12 cells[2].Cardiogenol C (0.001-100 μM; 7 days) increases cardiac Nav1.5 sodium channel protein expression as dose-dependent manner in C2C12 cells[2].Cardiogenol C (0.01-100 μM; 7 days) does not effect cell growth even at 10 μM. In addition, Cardiogenol C either solves in water or DMSO generates a similar effect. The highest concentration, 100 μM has significant cellular toxicity on C2C12 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:C2C12 cells
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Concentration:0.01 μM; 0.1 μM; 1 μM; 3 μM; 10 μM; 30 μM; 100 μM
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Incubation Time:7 days
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Result:Increases ANF and NKX2.5 mRNA level as a dose-dependent manner.
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Cell Line:C2C12 cells
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Concentration:0.001 μM; 0.01 μM; 0.1 μM; 1 μM; 10 μM
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Incubation Time:7 days
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Result:Increased cardiac Nav1.5 sodium channel protein levels.
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Cell Line:C2C12 cells
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Concentration:0.01 μM; 0.1 μM; 1 μM
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Incubation Time:7 days
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Result:Did not exert toxic effects on C2C12 cells at 0.01-10 μM treatment.
Chemical Information
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CAS. Nr. 671225-39-1
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Molecular Weight 260.29
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Formel C13H16N4O2
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SMILES
COC1=CC=C(NC2=NC=CC(NCCO)=N2)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Wu X, et al. Small molecules that induce cardiomyogenesis in embryonic stem cells.J Am Chem Soc. 2004 Feb 18;126(6):1590-1. [Content Brief]
[2]. Mike AK, et al. Small molecule cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells. Cell Physiol Biochem. 2014;33(1):205-21. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Cardiogenol C Related Classifications
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