Art. -Nr.: HY-N0220

Dauricine

3 Cited Publications

Kundenbewertung

Based on 3 publication(s) in Google Scholar

Dauricine, a bisbenzylisoquinoline alkaloid in Menispermum dauricum, possesses anti-inflammatory activity. Dauricine inhibits cell proliferation and invasion, and induces apoptosis by suppressing NF-κB activation in a dose- and time-dependent manner in colon cancer.

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Reinheit: 99.68%
CAS. Nr.: 524-17-4
Formel: C₃₈H₄₄N₂O₆
Molecular Weight:624.77

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Dauricine Chemical Structure

CAS. Nr.: 524-17-4

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle NF-κB Isoform-spezifische Produkte anzeigen :

In Vitro

Dauricine (0-20 μM, 8 days) inhibits cell growth of HCT116, HCT8, SW620, and SW480 cells^[1].
Dauricine (0-20 μM, 12 and 24 h) causes G1 phase cell-cycle arrest in HCT116 cells^[1].
Dauricine (0-20 μM, 36 h) induces cell apoptosis and inhibits cell invasion in HCT116 cells^[1].
Dauricine (0-20 μM, 6 h) inhibits the activation of NF-κB signaling pathway in HCT116 cells^[1].
Dauricine (1 and 2 μg/mL, 24 h) inhibits glucose glycolysis and increased oxidative phosphorylation in HepG2 and Huh-7 cells^[3].
Dauricine (2 μg/mL, 48 h) increases the sensitivities of HCC cell lines to both Cisplatin (HY-17394) and Sorafenib (HY-10201)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

HCT 116
Concentration:

5, 10, 20 μM
Incubation Time:

36 h
Result:

Showed he percentages of apoptotic rate of 7.8% to 14.4%, 19.8%, and 29.7% at 5, 10, and 20 μM.
Increased the accumulation of cleavage PARP and caspase3.

Western Blot Analysis^[1]

Cell Line:

HCT 116
Concentration:

5, 10, 20 μM
Incubation Time:

36 h
Result:

Inhibited the TNF (0.5 nM)-induced phosphorylation and nuclear translocation of p65.

In Vivo

Dauricine (s.c., 40 mg/kg, every 2-day. for 9 days) inhibits colonic tumor growth in a HCT116 xenograft mouse model^[1].
Dauricine (1 or 10 mg/kg, i.p.) ameliorates cognitive impairment, reduces Aβ Accumulation and Tau hyperphosphorylation in 3xTg-Alzheimer's Disease mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

HCT116 xenograft mouse model^[1]
Dosage:

40 mg/kg
Administration:

s.c., every 2-day. for 9 days
Result:

Inhibited colonic tumor growth completely at 9 days, with little effect on body weight.

Chemical Information

CAS. Nr. 524-17-4
Appearance Solid
Molecular Weight 624.77
Formel C₃₈H₄₄N₂O₆
Color White to off-white
SMILES

OC1=CC=C(C[C@H]2N(C)CCC3=C2C=C(OC)C(OC)=C3)C=C1OC4=CC=C(C[C@H]5N(C)CCC6=C5C=C(OC)C(OC)=C6)C=C4
Structure Classification
- Alkaloids
- Isoquinoline Alkaloids
- Phenols
- Monophenols
Initial Source
- Plants
- other families
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (3)

All Cell Proliferation/Viability AssayRT-PCRWBHistological Imaging/StainingCell Imaging/Staining

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Journal Impact Factor

Biochem Pharmacol

Dauricine regulates prostate cancer progression by inhibiting PI3K/AKT-dependent M2 polarization of macrophages. [Abstract]

2023 Nov:217:115838. PMID: 37778445
Food Sci Nutr

Dauricine Inhibits Macrophages M2 Polarization and Regulates the Progression and Ferroptosis via HCK/IDO1 in Urinary Bladder Cancer. [Abstract]

2025 Dec 21;13(12):e71341. PMID: 41438182

Dauricine purchased from MedChemExpress. Usage Cited in: Food Sci Nutr. 2025 Dec 21;13(12):e71341. [Abstract]

CCK-8 assay of cell viability of RAW264.7 cells and BLCA cells treated with different concentrations of Dauricine (DAU) (0, 5, 10, 20, 40, and 80 μM) for 24 h.

Dauricine purchased from MedChemExpress. Usage Cited in: Food Sci Nutr. 2025 Dec 21;13(12):e71341. [Abstract]

qRT‐PCR analysis of HCK in RAW264.7 cells cultured with BLCA cell supernatants with or without Dauricine (DAU) (5 μM).

Dauricine purchased from MedChemExpress. Usage Cited in: Food Sci Nutr. 2025 Dec 21;13(12):e71341. [Abstract]

Western blot of EMT markers in TAMs‐induced BLCA cells for 24 h with or without Dauricine (DAU) (5 μM) treatment.

Dauricine purchased from MedChemExpress. Usage Cited in: Food Sci Nutr. 2025 Dec 21;13(12):e71341. [Abstract]

Representative images of tumors IHC analysis treated with Dauricine (DAU) (10 mg/kg, i.p.).

Dauricine purchased from MedChemExpress. Usage Cited in: Food Sci Nutr. 2025 Dec 21;13(12):e71341. [Abstract]

Fluorescent image analysis shows that ROS levels were significantly reduced in the M2‐like TAM‐CM group but rebounded after Dauricine (DAU) (5 μM) treatment.
Chemrxiv

Oct 12, 2021.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (160.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.6006 mL

8.0029 mL

16.0059 mL

5 mM

0.3201 mL

1.6006 mL

3.2012 mL

10 mM

0.1601 mL

0.8003 mL

1.6006 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (4.00 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (4.00 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (4.00 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yang Z, et al. Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells. J Cell Physiol. 2010 Oct;225(1):266-75. [Content Brief]

[2]. Chen C, et al. Dauricine Attenuates Spatial Memory Impairment and Alzheimer-Like Pathologies by Enhancing Mitochondrial Function in a Mouse Model of Alzheimer's Disease. Front Cell Dev Biol. 2021 Feb 5;8:624339. [Content Brief]

[3]. Li W, et al. Dauricine upregulates the chemosensitivity of hepatocellular carcinoma cells: Role of repressing glycolysis via miR-199a:HK2/PKM2 modulation. Food Chem Toxicol. 2018 Nov;121:156-165. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.6006 mL	8.0029 mL	16.0059 mL	40.0147 mL
	5 mM	0.3201 mL	1.6006 mL	3.2012 mL	8.0029 mL
	10 mM	0.1601 mL	0.8003 mL	1.6006 mL	4.0015 mL
	15 mM	0.1067 mL	0.5335 mL	1.0671 mL	2.6676 mL
	20 mM	0.0800 mL	0.4001 mL	0.8003 mL	2.0007 mL
	25 mM	0.0640 mL	0.3201 mL	0.6402 mL	1.6006 mL
	30 mM	0.0534 mL	0.2668 mL	0.5335 mL	1.3338 mL
	40 mM	0.0400 mL	0.2001 mL	0.4001 mL	1.0004 mL
	50 mM	0.0320 mL	0.1601 mL	0.3201 mL	0.8003 mL
	60 mM	0.0267 mL	0.1334 mL	0.2668 mL	0.6669 mL
	80 mM	0.0200 mL	0.1000 mL	0.2001 mL	0.5002 mL
	100 mM	0.0160 mL	0.0800 mL	0.1601 mL	0.4001 mL

Keywords

Dauricine

3 Cited Publications

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Dauricine

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Stem Cell Signaling Compound Library

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Publications Citing Use of MedChemExpress (MCE) Dauricine

Alle NF-κB Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (3)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Dauricine Related Classifications

Art. -Nr.: HY-N0220