E17241
E17241 is an inducer of the expression of ABCA1 that increases the protein levels of ABCA1 in RAW 264.7 macrophages. E17241 is also an agonist of peroxisome proliferator-activated receptors (PPARs ). E17241 decreases plasma glucose levels and body weight in KKAy diabetic mice fed a high-fat and high-glucose (HFHG) diet.
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- Reinheit: 95.04%
- CAS. Nr.: 1060968-92-4
- Formel: C15H14N2O2S2
- Molecular Weight:318.41
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Chemical Information
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CAS. Nr. 1060968-92-4
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Appearance Powder
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Molecular Weight 318.41
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Formel C15H14N2O2S2
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Color Off-white to light yellow
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SMILES
O=C(C1=CC=C(C2SCCS2)C=C1)NC3=NC=CC=C3O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Lösungsmittel & Löslichkeit
DMSO : 12.5 mg/mL (39.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Sheng R, et al. A pan-PPAR agonist E17241 ameliorates hyperglycemia and diabetic dyslipidemia in KKAy mice via up-regulating ABCA1 in islet, liver, and white adipose tissue. Biomed Pharmacother. 2024 Mar;172:116220. [Content Brief]
[2]. Xu Y, et al. E17241 as a novel ABCA1 (ATP-binding cassette transporter A1) upregulator ameliorates atherosclerosis in mice[J]. Arteriosclerosis, Thrombosis, and Vascular Biology, 2021, 41(6): e284-e298. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1406 mL | 15.7030 mL | 31.4060 mL | 78.5151 mL |
| 5 mM | 0.6281 mL | 3.1406 mL | 6.2812 mL | 15.7030 mL | |
| 10 mM | 0.3141 mL | 1.5703 mL | 3.1406 mL | 7.8515 mL | |
| 15 mM | 0.2094 mL | 1.0469 mL | 2.0937 mL | 5.2343 mL | |
| 20 mM | 0.1570 mL | 0.7852 mL | 1.5703 mL | 3.9258 mL | |
| 25 mM | 0.1256 mL | 0.6281 mL | 1.2562 mL | 3.1406 mL | |
| 30 mM | 0.1047 mL | 0.5234 mL | 1.0469 mL | 2.6172 mL |
E17241 Related Classifications
HY-W201317 Related Classifications
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