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Art. -Nr.: HY-N15319

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Eupolauridine

(Synonyms: Canangine)

Eupolauridine (Canangine) is a selective DNA topoisomerase II inhibitor with IC₅₀ values of 20 μM for fungal topoisomerase I and 33 μM for human topoisomerase I. Eupolauridine exerts antifungal activity by inhibiting the catalytic activity of topoisomerase II and stabilizing its cleavage complex with DNA, leading to DNA damage. Eupolauridine is promising for research of fungal infectious diseases.

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CAS. Nr.: 58786-39-3
Formel: C₁₄H₈N₂
Molecular Weight:204.23

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Eupolauridine Chemical Structure

CAS. Nr.: 58786-39-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Topoisomerase I

Topoisomerase II

Alle Topoisomerase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	35.7 μM Compound: 5	Antiproliferative activity against human A2780 cells after 2 days by Alamar Blue assay Antiproliferative activity against human A2780 cells after 2 days by Alamar Blue assay	[PMID: 21504145]
NCI-H460	IC₅₀	>100 μM Compound: 5	Antiproliferative activity against human H460 cells after 96 hrs by Cell Titre-Glo luminescent assay Antiproliferative activity against human H460 cells after 96 hrs by Cell Titre-Glo luminescent assay	[PMID: 21504145]
SK-OV-3	IC₅₀	>10 μg/mL Compound: Eupo	Cytotoxicity against human SKOV3 cells assessed as cell growth inhibition after 48 hrs by neutral red dye based assay Cytotoxicity against human SKOV3 cells assessed as cell growth inhibition after 48 hrs by neutral red dye based assay	[PMID: 27769668]
Vero	IC₅₀	>10 μg/mL Compound: Eupo	Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition after 48 hrs by neutral red dye based assay Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition after 48 hrs by neutral red dye based assay	[PMID: 27769668]

Chemical Information

CAS. Nr. 58786-39-3
Molecular Weight 204.23
Formel C₁₄H₈N₂
SMILES

C1(C2=CC=CC=C23)=NC=CC4=C1C3=NC=C4
Synonyms

Canangine
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Khan SI, et al. Antifungal activity of eupolauridine and its action on DNA topoisomerases. Antimicrob Agents Chemother. 2002 Jun;46(6):1785-92. [Content Brief]

[2]. Lavanya M, et al. Synthesis and Anticancer Properties of Functionalized 1,6-Naphthyridines. Top Curr Chem (Cham). 2021 Feb 24;379(2):13. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
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Eupolauridine

Alle Topoisomerase Isoform-spezifische Produkte anzeigen