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Art. -Nr.: HY-P990741

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Biologically Validated

Galvokimig

Name: Galvokimig
Brand: MedChemExpress
SKU: HY-P990741
Price: 520.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: UCB-9741)

Kundenbewertung

Based on 1 Customer Validation

Galvokimig (UCB-9741) is an anti-IL-13/IL-17A/albumin (ALB)/IL-17F trispecific Fab-scFv fusion protein. Galvokimig simultaneously binds IL-13 and IL-17 with high affinity and has an extended half-life through albumin binding. Galvokimig inhibits IL-13-mediated, IL-17A-mediated, and IL-17F-mediated signaling. Galvokimig inhibits IL-17A- and IL-17F-induced IL-6 release in dermal fibroblasts and inhibits IL-19 and IL-24 production in primary epidermal keratinocytes. Galvokimig can be used for research on atopic dermatitis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 99.71%
CAS. Nr.: 2648456-30-6
Molecular Weight:101.953 kDa

Speicherung:

Shipping with dry ice

Please store the product under the recommended conditions in the Certificate of Analysis.

Galvokimig Chemical Structure

CAS. Nr.: 2648456-30-6

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Isotype
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconstitution
- Format
- Anwendung
- Verified Bioactivity
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isotype

Fab-G1-kappa-[scFv-heavy-kappa]2

Species Reactivity

Human

IC₅₀ & Target

IL13 & IL17A & ALB & IL17F

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

In Vitro

Cytokines and Chemokines

Galvokimig concurrently binds IL-13 and IL-17 with high affinity in SPR assays^[1].
Galvokimig effectively inhibits IL-13-, IL-17A-, and IL-17F-induced intracellular signalling in HEK-Blue IL-4/IL-13 cells expressing the SEAP reporter gene^[1].
Galvokimig inhibits IL-17A- and IL-17F-induced IL-6 release in dermal fibroblasts^[1].
Galvokimig suppresses IL-13/IL-17-induced IL-19 and IL-24 production in primary human epidermal keratinocytes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Gene ID

3596 [NCBI] & 3605 [NCBI] & 213 [NCBI] & 21790 [NCBI]

Accession

P35225 & Q16552 & P02768 & Q9UHF5

Conjugated

Unconjugated

Reconstitution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Fab-G1_kappa-scFv-heavy-kappa

Anwendung

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized IL-13 Protein, Human (HEK293, His, HY-P70568) can bind Galvokimig. The EC₅₀ for this effect is 941.7 ng/mL.
Immobilized IL-17A Protein, Human (HEK293, His, HY-P70527) can bind Galvokimig. The EC₅₀ for this effect is 31.32 ng/mL.
Immobilized Serum Albumin/ALB Protein, Human (HEK293, His-Avi, HY-P78393) can bind Galvokimig. The EC₅₀ for this effect is 10.4 ng/mL.
Immobilized IL-17F Protein, Human (HEK293, His, HY-P70540) can bind Galvokimig. The EC₅₀ for this effect is 595.9 ng/mL.

Chemical Information

CAS. Nr. 2648456-30-6
Appearance Liquid
Molecular Weight 101.953 kDa
Color Colorless to light yellow
Synonyms

UCB-9741
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Verweise

[1].
S Stanyon, et al. Galvokimig, a multispecific antibody–based therapeutic, for the treatment of inflammatory skin diseases associated with both type 2 and type 3 inflammation. Volume 145, Issue 12, Supplement S270December 2025.

[2].
Hamish J.A. Hunter, et al. 247 A first-in-patient 18-week study of galvokimig, a multispecific antibody-based therapeutic targeting interleukin (IL)-13, IL-17A, and IL-17F in participants with moderate-to-severe atopic dermatitis (AD). Volume 145, Issue 11, Supplement e70November 2025.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- Isotype
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconstitution
- Format
- Anwendung
- Biological Activity
Chemical Information
Reinheit & Dokumentation
Verweise

1/16

Fab-G1_kappa-scFv-heavy-kappa
1/16

Immobilized IL-13 Protein, Human (HEK293, His, HY-P70568) can bind Galvokimig. The EC₅₀ for this effect is 941.7 ng/mL.
1/16

Immobilized IL-17A Protein, Human (HEK293, His, HY-P70527) can bind Galvokimig. The EC₅₀ for this effect is 31.32 ng/mL.
1/16

Immobilized Serum Albumin/ALB Protein, Human (HEK293, His-Avi, HY-P78393) can bind Galvokimig. The EC₅₀ for this effect is 10.4 ng/mL.
1/16

Immobilized IL-17F Protein, Human (HEK293, His, HY-P70540) can bind Galvokimig. The EC₅₀ for this effect is 595.9 ng/mL.
1/16

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Galvokimig

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