Tlr4 - toll-like receptor 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29260

About Tlr4

Primary_assembly 5: 80,145,826-80,159,628 forward strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 127 orthologues, 26 paralogues and is associated with 182 phenotypes. Biased expression in Lung (RPKM 171.1), Spleen (RPKM 11.9) and 9 other tissues.

Summary

Enables lipopolysaccharide binding activity and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; immune response-regulating signaling pathway; and response to steroid hormone. Located in cell surface and cytoplasm. Colocalizes with membrane raft. Used to study several diseases, including carotid stenosis; ileitis; neuropathy (multiple); obesity; and renal fibrosis. Biomarker of several diseases, including kidney failure (multiple); pancreatitis (multiple); perinatal necrotizing enterocolitis; pulpitis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including allergic contact dermatitis (multiple); artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human TLR4 (toll like receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Tlr4 Products (1)

mRNA Protein Name
NM_019178.2 NP_062051.2 toll-like receptor 4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables lipopolysaccharide binding IDA
IDA: Inferred from direct assay
16973131 RGD
enables phosphatidylinositol 3-kinase binding IPI
IPI: Inferred from physical interaction
14962484 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
14962484 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
20438866 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
20202224 RGD
involved in cellular response to retinoic acid IEP
IEP: Inferred from expression pattern
20438866 RGD
involved in detection of mechanical stimulus involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
27760212 RGD
involved in detection of temperature stimulus involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
27760212 RGD
involved in immunoglobulin mediated immune response IEP
IEP: Inferred from expression pattern
19257980 RGD
involved in innate immune response-activating signaling pathway IMP
IMP: Inferred from mutant phenotype
19226379 RGD
involved in leukotriene metabolic process IDA
IDA: Inferred from direct assay
21765618 RGD
involved in microglial cell activation IDA
IDA: Inferred from direct assay
16973131 RGD
involved in positive regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
16272348 RGD
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
16651628 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16272348 RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
12616494 RGD
involved in regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
24199847 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
20007518 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
23277536 RGD
involved in response to ethanol IMP
IMP: Inferred from mutant phenotype
16272348 RGD
involved in response to fatty acid IDA
IDA: Inferred from direct assay
19144836 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
19141191 RGD
involved in response to gold nanoparticle IEP
IEP: Inferred from expression pattern
23150627 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
15535030 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
16740310 RGD
involved in response to lipopolysaccharide IDA
IDA: Inferred from direct assay
16973131 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
17167854 RGD
involved in response to oxidative stress IMP
IMP: Inferred from mutant phenotype
16847070 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
18316784 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
20438866 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
15535030 RGD
involved in skeletal muscle contraction IEP
IEP: Inferred from expression pattern
20007518 RGD
involved in toll-like receptor signaling pathway IDA
IDA: Inferred from direct assay
16973131 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in cell surface IDA
IDA: Inferred from direct assay
16847070 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tlr4 Protein Structure

PLN00113

PLN00113: cl33413 (22 - 455)

LRR_RI

LRR_RI: sd00033 (57 - 77)

LRR_RI

LRR_RI: sd00033 (78 - 101)

LRR_RI

LRR_RI: sd00033 (102 - 125)

LRR_RI

LRR_RI: sd00033 (126 - 149)

LRR_RI

LRR_RI: sd00033 (150 - 174)

LRR_RI

LRR_RI: sd00033 (175 - 203)

LRR_RI

LRR_RI: sd00033 (204 - 225)

LRR_RI

LRR_RI: sd00033 (255 - 309)

LRR_RI

LRR_RI: sd00033 (372 - 397)

LRR_RI

LRR_RI: sd00033 (398 - 420)

LRR_RI

LRR_RI: sd00033 (421 - 445)

LRR_RI

LRR_RI: sd00033 (446 - 469)

LRR_RI

LRR_RI: sd00033 (470 - 494)

LRR_8

LRR_8: pfam13855 (493 - 553)

LRR_RI

LRR_RI: sd00033 (495 - 518)

LRR_RI

LRR_RI: sd00033 (519 - 542)

LRR_RI

LRR_RI: sd00033 (543 - 566)

TIR

TIR: smart00255 (671 - 812)

  • 0
  • 200
  • 400
  • 600
  • 835 a.a.
Protein Preferred Names Protein Names

toll-like receptor 4

  • toll4

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-108910 Chymotrypsin Inhibitor / Unkown
HY-N0680 Thiamine hydrochloride Inhibitor 99.97% Unkown
HY-14806B Teneligliptin hydrobromide hydrate Inhibitor 99.97% Unkown
HY-130320 Monophosphoryl lipid A Agonist 99.87% Unkown
HY-W105835 Magnesium citrate Modulator 98.0% Unkown
HY-107352 Fosfenopril Inhibitor 99.85% Unkown

Clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-D1056 Lipopolysaccharides, from E. coli O55:B5 Activator / Phase 4
HY-N8277 Kdo2-Lipid A ammonium Activator 99.00% Phase 4
HY-11109 Resatorvid Inhibitor 99.95% Phase 3
HY-P10227 Xelafaslatide Inhibitor 99.88% Phase 2
HY-108910A Chymotrypsin (MS grade) Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (81)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-107575 TLR4-IN-C34 Inhibitor 99.94% Unkown
HY-N0703 Schaftoside Inhibitor 99.70% Unkown
HY-P1439 RS 09 Agonist 99.88% Unkown
HY-116213 Sparstolonin B Antagonist 99.94% Unkown
HY-N0108 Physcion Inhibitor 99.40% Unkown
HY-N6673 Okanin Inhibitor 99.98% Unkown
HY-N6612 D-Glucuronic acid Agonist 98.0% Unkown
HY-125171 IAXO-102 Antagonist 98.0% Unkown
HY-N1346 Robinin Inhibitor 99.96% Unkown
HY-N0774 Isofraxidin Inhibitor 99.94% Unkown
HY-N7700A Guluronic acid sodium Inhibitor 98.0% Unkown
HY-P1439A RS 09 TFA Agonist 99.87% Unkown
HY-159069 Zymosan (ZM), 95% Activator 96.11% Unkown
HY-Y0278 Chloranil Inducer 98% Unkown
HY-U00435 Neoseptin 3 Agonist 99.21% Unkown
HY-18325 AN-3485 Inhibitor 97.38% Unkown
HY-N2345 Procyanidin B3 Inhibitor 99.92% Unkown
HY-N2110 Phellopterin Inhibitor 99.94% Unkown
HY-103483 MD2-IN-1 Inhibitor 99.88% Unkown
HY-128598 MD2-TLR4-IN-1 Inhibitor 98.16% Unkown
HY-W082785A L6H21 Inhibitor 99.19% Unkown
HY-N1508 Ecliptasaponin A Inhibitor 99.81% Unkown
HY-N2055 Kaempferol 3-O-sophoroside Inhibitor 99.41% Unkown
HY-N0726 Dracorhodin perchlorate Modulator 99.02% Unkown
HY-124750 NecroX-7 Inhibitor 99.69% Unkown
HY-P10208A RKH acetate Antagonist 99.79% Unkown
HY-N0392 Polygalasaponin F Inhibitor 99.85% Unkown
HY-101318 β-Funaltrexamine hydrochloride Inhibitor 99.07% Unkown
HY-135042 CAY10614 Antagonist 98.87% Unkown
HY-N4093 Astringin Inhibitor 99.54% Unkown
HY-129440 N-(p-Coumaroyl) Serotonin Inhibitor 99.03% Unkown
HY-175222 GlcNAc-MurNAc Inhibitor 95.37% Unkown
HY-N7627 Regaloside C Chemical 99.62% Unkown
HY-126154 L48H37 Inhibitor 97.13% Unkown
HY-146195 MAPK-IN-1 Inhibitor 98.11% Unkown
HY-175674 NGI-235 99.70% Unkown
HY-NP192 Sericin Inhibitor 0% Unkown
HY-168710 TLR4/NF-κB-IN-1 Inhibitor 99.92% Unkown
HY-N6928 Mogroside III-E Inhibitor 99.30% Unkown
HY-N0320 Salvianolic acid D Inhibitor 95.15% Unkown
HY-N8284 Tomentosin Inhibitor 98.95% Unkown
HY-W012837 Benzylmethyl ether 98.70% Unkown
HY-N3097 Pellitorine Inhibitor 99.84% Unkown
HY-P10897 SjDX5-271 Inhibitor 98.90% Unkown
HY-145245 TLR4-IN-C34-C2-amide-C6-OH Inhibitor 99.62% Unkown
HY-178037 TLR9 antagonist 1 Antagonist / Unkown
HY-N12378 β-Patchoulene Inhibitor 96.88% Unkown
HY-179474 TSI-13-57 Inhibitor 98.73% Unkown
HY-N7700 Guluronic acid Inhibitor 98.90% Unkown
HY-W041608 Methylchloroisothiazolinone Activator / Unkown
HY-146560 Xanthine oxidase-IN-6 Inhibitor / Unkown
HY-179646 CIAC101 Antagonist / Unkown
HY-145253 Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH Inhibitor / Unkown
HY-182034 GAP214 Agonist / Unkown
HY-N8903 Mumefural Inhibitor 95.17% Unkown
HY-14750 Rabeximod / Unkown
HY-169057 BI1543673 Inhibitor / Unkown
HY-186062 HCN-IN-1 Inhibitor / Unkown
HY-165386 TU-100 Inhibitor / Unkown
HY-173388A rel-TLR4-IN-2 Inhibitor / Unkown
HY-N17383 Ligusticum cycloprolactam Inhibitor / Unkown
HY-P11442 Lytx-Pa2a Inhibitor / Unkown
HY-183573 PTPRO-IN-1 Inhibitor / Unkown
HY-176755 CCL-34 Activator / Unkown
HY-N19847 LYRM03 Inhibitor / Unkown
HY-P11580 Pap12-6-10 Inhibitor / Unkown
HY-179036 APG-7 / Unkown
HY-P11093 Papiliocin Inhibitor / Unkown
HY-176837 NOD2/TLR4 agonist-1 Agonist / Unkown
HY-174465 TLR4L 10 Ligand / Unkown
HY-129684 IAXO-101 iodide Inhibitor / Unkown
HY-162004 NF-κB-IN-14 Inhibitor / Unkown
HY-N6612A D-Glucuronic acid sodium salt monohydrate Agonist 98.0% Unkown
HY-145255 Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH Inhibitor / Unkown
HY-160938 β-Funaltrexamine Inhibitor / Unkown
HY-P11250 HVF18-a3-d Inhibitor / Unkown
HY-180336 LM9 Inhibitor / Unkown
HY-N16021 4A-MPLA ammonium Agonist / Unkown
HY-165632 Creatine ethyl ester Activator / Unkown
HY-W127601 Lard oil Activator / Unkown
HY-N7697C Chitohexaose hexahydrochloride Inhibitor 95.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tlr4 NCBI NCBI:7099