VAPB - VAMP associated protein B and C Gene

Also Known as ALS8; VAP-B; VAMP-B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9217

About VAPB

Cytogenetic location: 20q13.32 Genomic coordinates (GRCh38): 20:58,389,229-58,451,101 (from NCBI)

This gene has 6 transcripts (splice variants), 275 orthologues, 1 paralogue and is associated with 4 phenotypes. Ubiquitous expression in thyroid (RPKM 14.9), brain (RPKM 14.3) and 25 other tissues.

Summary

The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008]

VAPB Products (2)

mRNA	Protein	Name
NM_001195677.2	NP_001182606.1	vesicle-associated membrane protein-associated protein B/C isoform 2
NM_004738.5	NP_004729.1	vesicle-associated membrane protein-associated protein B/C isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables FFAT motif binding	IDA IDA: Inferred from direct assay	33124732	GOA
enables FFAT motif binding	IMP IMP: Inferred from mutant phenotype	18713837	GOA
enables FFAT motif binding	IPI IPI: Inferred from physical interaction	24105263	GOA
enables beta-tubulin binding	IDA IDA: Inferred from direct assay	17540579	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	17540579	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	18713837	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9920726	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	9920726	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	9920726	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in COPII-coated vesicle budding	IMP IMP: Inferred from mutant phenotype	18713837	GOA
involved in IRE1-mediated unfolded protein response	IDA IDA: Inferred from direct assay	20940299	GOA
involved in cholesterol transport	IDA IDA: Inferred from direct assay	33124732	GOA
involved in endoplasmic reticulum organization	IMP IMP: Inferred from mutant phenotype	18713837	GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	18713837	GOA
involved in endoplasmic reticulum unfolded protein response	IMP IMP: Inferred from mutant phenotype	16891305	GOA
involved in intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	22131369	GOA
involved in modulation by host of viral RNA genome replication	IDA IDA: Inferred from direct assay	19515777	GOA
involved in negative regulation by host of viral genome replication	IDA IDA: Inferred from direct assay	19515777	GOA
involved in negative regulation by virus of viral protein levels in host cell	IDA IDA: Inferred from direct assay	19515777	GOA
involved in positive regulation by host of viral genome replication	IDA IDA: Inferred from direct assay	19515777	GOA
involved in positive regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	16227268	GOA
involved in suppression of viral release by host	IDA IDA: Inferred from direct assay	19515777	GOA
involved in viral release from host cell	IDA IDA: Inferred from direct assay	19515777	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	16227268	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	25468996	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15372378	GOA
NOT located in endoplasmic reticulum exit site	IDA IDA: Inferred from direct assay	18713837	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	16227268	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VAPB Protein Structure

Motile_Sperm

0
100
200
243 a.a.

Protein Preferred Names	Protein Names
vesicle-associated membrane protein-associated protein B/C	VAMP (vesicle-associated membrane protein)-associated protein B and C

VAPB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	VAPB	O95292	GPR25	Homo sapiens	O00155	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	ARL16	Homo sapiens	Q0P5N6	Y2H Array	32814053
Intra	VAPB	O95292	ARL16	Homo sapiens	Q0P5N6	Y2H Pooling	32814053
Intra	VAPB	O95292	ARL16	Homo sapiens	Q0P5N6	Validated Y2H	32814053
Intra	VAPB	O95292	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
Intra	VAPB	O95292	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	VAPB	O95292	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	VAPB	O95292	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	VAPB	O95292	KRTAP9-2	Homo sapiens	Q9BYQ4	Validated Y2H	32814053
Intra	VAPB	O95292	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Pooling	32814053
Intra	VAPB	O95292	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	32814053
Intra	VAPB	O95292	VAPA	Homo sapiens	Q9P0L0	Anti Tag CoIP	33961781
Intra	VAPB	O95292	VAPA	Homo sapiens	Q9P0L0	Anti Tag CoIP	35271311
Intra	VAPB	O95292	PTGES	Homo sapiens	O14684	Y2H Array	32296183
Intra	VAPB	O95292	PTGES	Homo sapiens	O14684	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	AP2B1	Homo sapiens	P63010-2	Validated Y2H	32814053
Intra	VAPB	O95292	AP2B1	Homo sapiens	P63010-2	Y2H Array	32814053
Intra	VAPB	O95292	AP2B1	Homo sapiens	P63010-2	Y2H Pooling	32814053
Intra	VAPB	O95292	AIG1	Homo sapiens	Q9NVV5-2	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	AIG1	Homo sapiens	Q9NVV5-2	Validated Y2H	32296183
Intra	VAPB	O95292	AIG1	Homo sapiens	Q9NVV5-2	Y2H Array	32296183
Intra	VAPB	O95292	ZDHHC15	Homo sapiens	Q96MV8	Y2H Array	32296183
Intra	VAPB	O95292	ZDHHC15	Homo sapiens	Q96MV8	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	ZDHHC15	Homo sapiens	Q96MV8	Validated Y2H	32296183
Intra	VAPB	O95292	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	VAPB	O95292	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	VAPB	O95292	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	VAPB	O95292	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	VAPB	O95292	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	VAPB	O95292	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	VAPB	O95292	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	VAPB	O95292	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	VAPB	O95292	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	RNASEK	Homo sapiens	Q6P5S7	Validated Y2H	32296183
Intra	VAPB	O95292	RNASEK	Homo sapiens	Q6P5S7	Y2H Array	32296183
Intra	VAPB	O95292	RNASEK	Homo sapiens	Q6P5S7	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	VAPB	O95292	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	VAPB	O95292	FAM174A	Homo sapiens	Q8TBP5	Validated Y2H	32296183
Intra	VAPB	O95292	FAM174A	Homo sapiens	Q8TBP5	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	FAM174A	Homo sapiens	Q8TBP5	Y2H Array	32296183
Intra	VAPB	O95292	USP20	Homo sapiens	Q9Y2K6	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	USP20	Homo sapiens	Q9Y2K6	Y2H Array	32296183
Intra	VAPB	O95292	USP20	Homo sapiens	Q9Y2K6	Anti Tag CoIP	33961781
Intra	VAPB	O95292	USP20	Homo sapiens	Q9Y2K6	Anti Tag CoIP	28514442
Intra	VAPB	O95292	YIF1A	Homo sapiens	O95070	IF	23736259
Intra	VAPB	O95292	YIF1A	Homo sapiens	O95070	Pull Down	23736259
Intra	VAPB	O95292	YIF1A	Homo sapiens	O95070	Anti Tag CoIP	23736259
Intra	VAPB	O95292	RMDN2	Homo sapiens	Q96LZ7	Validated Y2H	32296183
Intra	VAPB	O95292	RMDN2	Homo sapiens	Q96LZ7	Anti Tag CoIP	33961781
Intra	VAPB	O95292	RMDN2	Homo sapiens	Q96LZ7	Anti Tag CoIP	28514442
Intra	VAPB	O95292	RMDN2	Homo sapiens	Q96LZ7	Anti Tag CoIP	35271311
Intra	VAPB	O95292	OSBPL2	Homo sapiens	Q9H1P3	Anti Tag CoIP	33961781
Intra	VAPB	O95292	CFTR	Homo sapiens	P13569	Ub Reconstruction	35156780
Intra	VAPB	O95292	SKIC8	Homo sapiens	Q9GZS3	Y2H Pooling	32814053
Intra	VAPB	O95292	SKIC8	Homo sapiens	Q9GZS3	Validated Y2H	32814053
Intra	VAPB	O95292	SKIC8	Homo sapiens	Q9GZS3	Y2H Array	32814053
Intra	VAPB	O95292	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
Intra	VAPB	O95292	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	VAPB	O95292	TMEM101	Homo sapiens	Q96IK0	Validated Y2H	32296183
Intra	VAPB	O95292	TMEM101	Homo sapiens	Q96IK0	Y2H Array	32296183
Intra	VAPB	O95292	TMEM101	Homo sapiens	Q96IK0	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	TTC39B	Homo sapiens	Q5VTQ0	Anti Tag CoIP	33961781
Intra	VAPB	O95292	TTC39B	Homo sapiens	Q5VTQ0	Validated Y2H	32296183
Intra	VAPB	O95292	TTC39B	Homo sapiens	Q5VTQ0	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	TTC39B	Homo sapiens	Q5VTQ0	Y2H Array	32296183
Intra	VAPB	O95292	EMD	Homo sapiens	P50402	Anti Tag CoIP	35271311
Intra	VAPB	O95292	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	VAPB	O95292	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	VAPB	O95292	ZBTB22	Homo sapiens	O15209	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	ZBTB22	Homo sapiens	O15209	Y2H Array	32296183
Intra	VAPB	O95292	SDCBP	Homo sapiens	O00560	Y2H Array	32814053
Intra	VAPB	O95292	SDCBP	Homo sapiens	O00560	Validated Y2H	32814053
Intra	VAPB	O95292	SDCBP	Homo sapiens	O00560	Y2H Pooling	32814053
Intra	VAPB	O95292	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	VAPB	O95292	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	VAPB	O95292	OSBPL1A	Homo sapiens	Q9BXW6	Anti Tag CoIP	33961781
Intra	VAPB	O95292	OSBPL1A	Homo sapiens	Q9BXW6	Anti Tag CoIP	28514442
Intra	VAPB	O95292	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	CD79A	Homo sapiens	P11912	Validated Y2H	32296183
Intra	VAPB	O95292	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	VAPB	O95292	CYBRD1	Homo sapiens	Q53TN4	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	CYBRD1	Homo sapiens	Q53TN4	Validated Y2H	32296183
Intra	VAPB	O95292	CYBRD1	Homo sapiens	Q53TN4	Y2H Array	32296183
Intra	VAPB	O95292	CYB561	Homo sapiens	P49447	Y2H Array	32296183
Intra	VAPB	O95292	CYB561	Homo sapiens	P49447	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	CYB561	Homo sapiens	P49447	Validated Y2H	32296183
Intra	VAPB	O95292	EBAG9	Homo sapiens	O00559	Y2H Prey Pooling	32296183
Intra	VAPB	O95292	EBAG9	Homo sapiens	O00559	Y2H Array	32296183
Intra	VAPB	O95292	TMEM252	Homo sapiens	Q8N6L7	Validated Y2H	32296183
Cross	VAPB	O95292	Q03463-PRO_0000278740	Hepatitis C virus	Q03463-PRO_0000278740	Confocal	16227268
Cross	VAPB	O95292	Q03463-PRO_0000278740	Hepatitis C virus	Q03463-PRO_0000278740	Y2H	16227268
Cross	VAPB	O95292	Q03463-PRO_0000278740	Hepatitis C virus	Q03463-PRO_0000278740	Anti Tag CoIP	16227268

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VAPB Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P71044	VAPB Protein, Human (His)	O95292 (A2-P132)	≥ 95%, as determined by reducing SDS-PAGE.

VAPB Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P89744	VAP-B/C Antibody (YA9088)	WB, IP, ELISA	human

Related Diseases

Diseases	Alias
Amyotrophic Lateral Sclerosis 8	Amyotrophic Lateral Sclerosis Type 8 ALS8 Sclerosis, Lateral, Amyotrophic, Type Type 8
Spinal Muscular Atrophy, Late-Onset, Finkel Type	Finkel Late-Adult Type Sma Spinal Muscular Atrophy, Proximal, Adult, Autosomal Dominant SMAFK SMAPAD Adult Proximal Spinal Muscular Atrophy, Autosomal Dominant Atrophy, Muscular, Spinal, Proximal, Adult, Autosomal Dominant
Autosomal Dominant Adult-Onset Proximal Spinal Muscular Atrophy	Autosomal Dominant Adult-Onset Proximal Sma Autosomal Dominant Late-Onset Spinal Muscular Atrophy, Finkel Type Finkel Disease Smafk Adult-Onset Proximal Spinal Muscular Atrophy, Autosomal Dominant Autosomal Dominant Adult Proximal Spinal Muscular Atrophy Finkel Late-Adult Type Sma
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Muscular Atrophy	Muscle Wasting Amyotrophia Wasting - Muscle Skeletal Muscle Atrophy
Spinal Muscular Atrophy	Sma 5q Sma Proximal Sma Sma-Associated Sma Spinal Amyotrophies Spinal Amyotrophy Spinal Muscle Degeneration Spinal Muscle Wasting Muscular Atrophy Spinal Atrophy, Muscular, Spinal Hereditary Motor Neuronopathy Progressive Muscular Atrophy Sma - [Spinal Muscular Atrophy]
Lateral Sclerosis	Primary Lateral Sclerosis Adult-Onset Primary Lateral Sclerosis Adult-Onset Pls Motor Neuron Disease Pls Pls - [Primary Lateral Sclerosis] Lateral Spinal Sclerosis Lateral Complete Paralysis Lateral Incomplete Paralysis Lateral Paralysis
Amyotrophic Lateral Sclerosis 21	Amyotrophic Lateral Sclerosis Type 21 ALS21 Multisystem Proteinopathy 5 Msp5 Distal Myopathy With Vocal Cord Weakness Vcpdm Myopathy, Distal, 2, Formerly Mpd2, Formerly Vocal Cord And Pharyngeal Dysfunction With Distal Myopathy, Formerly Vcpdm, Formerly Vocal Cord And Pharyngeal Distal Myopathy Matr3-Related Distal Myopathy Distal Myopathy 2 Mpd2 Vocal Cord And Pharyngeal Dysfunction With Distal Myopathy Sclerosis, Lateral, Amyotrophic, Type 21 Myopathy, Distal 2
Amyotrophic Lateral Sclerosis 11	Amyotrophic Lateral Sclerosis Type 11 ALS11 Sclerosis, Lateral, Amyotrophic, Type Type 11
Amyotrophic Lateral Sclerosis 10 With Or Without Frontotemporal Dementia	Amyotrophic Lateral Sclerosis Type 10 ALS10 Amyotrophic Lateral Sclerosis 10, With Or Without Ftd Frontotemporal Lobar Degeneration, Tardbp-Related Amyotrophic Lateral Sclerosis 10 Amyotrophic Lateral Sclerosis 10, With Or Without Frontotemporal Dementia Tardbp-Related Frontotemporal Lobar Degeneration With Tdp43 Inclusions Amyotrophic Lateral Sclerosis 10 With Or Without Frontotemporal Dementia And With Tdp43 Inclusions Sclerosis, Lateral, Amyotrophic, Type Type 10
Amyotrophic Lateral Sclerosis Type 12	Amyotrophic Lateral Sclerosis 12 Als12 Sclerosis, Lateral, Amyotrophic, Type Type 12
Spinocerebellar Ataxia 2	Spinocerebellar Ataxia Type 2 SCA2 Amyotrophic Lateral Sclerosis 13 Spinocerebellar Degeneration With Slow Eye Movements SDSEM Spinocerebellar Atrophy Ii Olivopontocerebellar Atrophy Ii Opca2 Cerebellar Degeneration With Slow Eye Movements Wadia-Swami Syndrome Amyotrophic Lateral Sclerosis Type 13 ALS13 Olivopontocerebellar Atrophy Holguin Type Spinocerebellar Ataxia Cuban Type Olivopontocerebellar Atrophy, Holguin Type Spinocerebellar Ataxia, Cuban Type Amyotrophic Lateral Sclerosis, Susceptibility To, 13 Olivopontocerebellar Atrophy 2 Sca 2 Spinocerebellar Ataxia With Slow Eye Movements Spinocerebellar Atrophy 2 Wadia Swami Syndrome Opca Ii Spinocerebellar Ataxia-2 Ataxia, Spinocerebellar, Type 2
Retinal Dystrophy With Leukodystrophy	RDLKD Acbd5 Deficiency Dystrophy, Retinal, With Leukodystrophy
Amyotrophic Lateral Sclerosis 16, Juvenile	Amyotrophic Lateral Sclerosis Type 16 ALS16 Amyotrophic Lateral Sclerosis 16 Sclerosis, Lateral, Amyotrophic, Type 16, Juvenile
Amyotrophic Lateral Sclerosis Type 6	Amyotrophic Lateral Sclerosis 6, Autosomal Recessive Als6 Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia Autosomal Recessive Amyotrophic Lateral Sclerosis 6 Sclerosis, Lateral, Amyotrophic, Type Type 6 Amyotrophic Lateral Sclerosis 6
Amyotrophic Lateral Sclerosis Type 15	Amyotrophic Lateral Sclerosis 15, With Or Without Frontotemporal Dementia Als15 Amyotrophic Lateral Sclerosis 15
Motor Neuron Disease	Anterior Horn Cell Disease Motor Neuron Diseases Mnd - [Motor Neurone Disease] Lou Gehrig Disease Creeping Palsy Creeping Paralysis Bulbar Motor Neuron Disease Bulbar Syndrome Anterior Horn Cell Disorder Hereditary Motor Neuron Disease
Amyotrophic Lateral Sclerosis 4, Juvenile	Amyotrophic Lateral Sclerosis Type 4 ALS4 Amyotrophic Lateral Sclerosis 4 Dhmn With Upper Motor Neuron Signs Distal Hereditary Motor Neuropathy With Upper Motor Neuron Signs Neuronopathy, Distal Hereditary Motor, With Pyramidal Features Als 4 Distal Hereditary Motor Neuropathy With Pyramidal Features Amyotrophic Lateral Sclerosis Juvenile 4 Neuronopathy Distal Hereditary Motor With Pyramidal Features Sclerosis, Lateral, Amyotrophic, Type Type 4
Amyotrophic Lateral Sclerosis Type 14	Als14 Amyotrophic Lateral Sclerosis 14 Amyotrophic Lateral Sclerosis, With Or Without Frontotemporal Dementia Amyotrophic Lateral Sclerosis 14 With Or Without Frontotemporal Dementia
Progressive Bulbar Palsy	Bulbar Palsy, Progressive Progressive Bulbar Atrophy Bulbar Palsy Pbp - [Progressive Bulbar Palsy] Progressive Bulbar Paralysis Bulbar Paralysis Chronic Bulbar Palsy Chronic Bulbar Paralysis Supranuclear Bulbar Paralysis
Amyotrophic Lateral Sclerosis 18	Amyotrophic Lateral Sclerosis Type 18 ALS18 Sclerosis, Lateral, Amyotrophic, Type 18
Progressive Muscular Atrophy	Progressive Spinal Muscular Atrophy Pure Progressive Muscular Atrophy Pma Hereditary Spinal Muscle Atrophy Pma - [Progressive Muscular Atrophy] Progressive Muscle Atrophy Progressive Spinal Muscle Atrophy Duchenne-Aran Atrophy Duchenne-Aran Muscle Atrophy Hereditary Sma - [Spinal Muscle Atrophy]
Mesenteric Lymphadenitis	Mesenteric Adenitis
Spinal Muscular Atrophy, Type Iv	SMA4 Spinal Muscular Atrophy, Adult Form Spinal Muscular Atrophy 4 Spinal Muscular Atrophy-4 Adult Spinal Muscular Atrophy Spinal Muscular Atrophy, Proximal, Adult, Autosomal Recessive Proximal Spinal Muscular Atrophy Type 4 Sma Type 4 Sma Type Iv Sma-Iv Sma Iv Spinal Muscular Atrophy Adult Form Spinal Muscular Atrophy Proximal Adult Autosomal Recessive Spinal Muscular Atrophy Type Iv Atrophy, Muscular, Spinal, Type Iv Myelopathic Muscular Atrophy
Dystonia 12	DYT12 Rdp Generalized Dystonia Dystonia-12 Rapid-Onset Dystonia-Parkinsonism Familial Dystonia Dystonia Musculorum Deformans Dystonic Disorders Idiopathic Familial Dystonia Dystonia-Parkinsonism, Rapid-Onset Fragments Of Torsion Dystonia Dyt-Atp1a3 Rapid-Onset Dystonia Parkinsonism Rodp Dystonia, Type 12 Dystonia 3, Torsion, X-Linked Idiopathic Non-Familial Dystonia Symptomatic Torsion Dystonia Dystonia Disorders
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1	FTDALS1 Frontotemporal Dementia And/Or Motor Neuron Disease Ftdmnd Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia Alsftd Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1 Frontotemporal Dementia With Motor Neuron Disease Ftdals Ftd-Als Ftd-Mnd Frontotemporal Dementia With Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1 Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1 Frontotemporal Lobar Degeneration Grn-Related Frontotemporal Dementia
Hemochromatosis, Type 1	Hemochromatosis Hemochromatosis Type 1 Hereditary Hemochromatosis Hh HFE1 Hfe Hemochromatosis, Modifier Of Symptomatic Form Of Classic Hemochromatosis Symptomatic Form Of Hemochromatosis Type 1 Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis Haemochromatosis Iron Storage Disorder Bronze Diabetes Hereditary Haemochromatosis Hlah Hfe Hemochromatosis, Hereditary Diabetes Bronze Classic Hemochromatosis Hfe-Associated Hereditary Hemochromatosis Hemochromatosis Classic Bronzed Cirrhosis Familial Hemochromatosis Genetic Hemochromatosis Hc Pigmentary Cirrhosis Primary Hemochromatosis Troisier-Hanot-Chauffard Syndrome Von Recklenhausen-Applebaum Disease Hemochromatosis 1 Primary Hereditary Hemochromatosis Bronze Cirrhosis
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Neuromuscular Disease	Neuromuscular Diseases Neuromuscular Disorders Neuromuscular Disorder
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS15603	VAPB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18156	Vapb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24630	Vapb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	VAPB	RGD	RGD:68326
Felis catus	VAPB	VGNC	VGNC:66918
Canis familiaris	VAPB	VGNC	VGNC:48230
Bos taurus	VAPB	VGNC	VGNC:36764
Mus musculus	VAPB	MGD	MGI:1928744
Others	VAPB	NCBI