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Art. -Nr.: HY-178224

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Morindone

Morindone is an anthraquinone found in Morinda citrifolia L. Morindone can inhibit cancer cells proliferation, induce apoptosis and cause G1 phase arrest. Morindone can inhibit activities of DNA polymerase and downregulate mutated TP53 and KRAS gene expression. Morindone can be used for the research of cancer, such as colon cancer.

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CAS. Nr.: 478-29-5
Formel: C₁₅H₁₀O₅
Molecular Weight:270.24

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Morindone Chemical Structure

CAS. Nr.: 478-29-5

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- In Vitro
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

DNA Polymerase

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In Vitro

Morindone (0.39-50 μM, 24-72 h) inhibits the proliferation of KRAS-mutant HCT116 and TP53-mutant HT29 colorectal cancer cells^[1].
Morindone (10.7-19.2 μM, 72 h) induces apoptosis in HCT116 and HT29 cells^[1].
Morindone (10.7-19.2 μM, 24-72 h) induces G1 phase arrest in HCT116 and HT29 cells^[1].
Morindone (10.7-19.2 μM, 72 h) downregulates mutated KRAS, BRAF, and mutated PIK3CA in HCT116 cells, and downregulates mutated TP53 and BAX, while upregulates p21 in HT29 cells^[1].
Morindone (28.1-35.9 μM, 60 mins) inhibits the activities of animal A-family, B-family and Y-family DNA polymerases with IC₅₀ values of 28.1-35.9 μM^[2].
Morindone (24 h) inhibits the proliferation of human colon cancer HCT116 cells with an LD₅₀of 32.2 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

KRAS-mutant HCT116 and TP53-mutant HT29 colorectal cancer cells
Concentration:

0.39, 0.78, 1.56, 3.12, 6.25, 12.5, 25 and 50 μM
Incubation Time:

24, 48 and 72 h
Result:

Showed 3.06% proliferation inhibition in HCT116 cells at 3.12 μM for 24 h and complete proliferation inhibition at 50 μM for 72 h.
Exhibited 20.5% inhibition at 0.78 μM for 24 h and over 90% inhibition at 12.5-50 μM for 72 h in HT29 cells.

Western Blot Analysis^[1]

Cell Line:

HCT116 and HT29 cells
Concentration:

10.7 μM for HCT116, 19.2 μM for HT29
Incubation Time:

72 h
Result:

Downregulated mutated KRAS, BRAF, and mutated PIK3CA in HCT116 cells.
Downregulated mutated TP53 and BAX, while upregulates p21 in HT29 cells.

Chemical Information

CAS. Nr. 478-29-5
Molecular Weight 270.24
Formel C₁₅H₁₀O₅
SMILES

O=C1C2=CC=C(C)C(O)=C2C(C3=CC=C(C(O)=C13)O)=O
Structure Classification
- Quinones
- Benzene Quinones
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chee CW, et al. Morindone as a potential therapeutic compound targeting TP53 and KRAS mutations in colorectal cancer cells. Chem Biol Interact. 2024 Apr 1;392:110928. [Content Brief]

[2]. Cheok Wui Chee, et al. Morindone as a potential therapeutic compound targeting TP53 and KRAS mutations in colorectal cancer cells, Chemico-Biological Interactions, Volume 392, 2024, 110928, ISSN 0009-2797.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
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- In Vitro
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Morindone

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Biologische Aktivität

Chemical Information

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Calculators

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Morindone Related Classifications

HY-178224 Related Classifications