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Art. -Nr.: HY-142119

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Penehyclidine

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Based on 1 publication(s) in Google Scholar

Penehyclidine, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation.

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CAS. Nr.: 87827-02-9
Formel: C₂₀H₂₉NO₂
Molecular Weight:315.45

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Data Sheet (270 KB)

Penehyclidine Chemical Structure

CAS. Nr.: 87827-02-9

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NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 87827-02-9
Molecular Weight 315.45
Formel C₂₀H₂₉NO₂
SMILES

OC(COC1CN2CCC1CC2)(C3CCCC3)C4=CC=CC=C4
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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J Pharm Biomed Anal

Study on the mechanism of action of Penehyclidine hydrochloride on LPS-induced acute lung injury by regulating autophagy through the mTOR/Keap1/Nrf2 signaling pathway. [Abstract]

2025 Apr 27:263:116938. PMID: 40306137

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ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
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MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
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Verweise

[1]. Zhi-Yuan Chen, et al. The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation. Int J Chron Obstruct Pulmon Dis. 2021 Mar 31;16:877-885. [Content Brief]

[2]. Xiao HT, et al. Penehyclidine hydrochloride: a potential drug for treating COPD by attenuating Toll-like receptors. Drug Des Devel Ther. 2012;6:317-22. [Content Brief]

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Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

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Penehyclidine

1 Cited Publications

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Penehyclidine

Publications Citing Use of MedChemExpress (MCE) Penehyclidine

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HY-142119 Related Classifications