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Art. -Nr.: HY-190554

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STK436742

STK436742 is a TRPV1 channel antagonist. STK436742 has anti-Amyloid-β propagation and anticancer effects. STK436742 can be used for pain research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 610266-79-0
Formel: C₁₈H₁₄N₂O₃
Molecular Weight:306.32

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

STK436742 Chemical Structure

CAS. Nr.: 610266-79-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

STK436742 is a TRPV1 channel antagonist. STK436742 has anti-Amyloid-β propagation and anticancer effects. STK436742 can be used for pain research^[1].

IC₅₀ & Target

^[1]

TRPV1

Alle TRP Channel Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC50	4.35 μM	Inhibition of capsaicin-induced TRPV1 calcium influx in HEK293 cells stably expressing TRPV1 assessed by FDSS/μCELL fluorescence Ca2+ assay using Fluo-4 AM after 20 min compound incubation. Inhibition of capsaicin-induced TRPV1 calcium influx in HEK293 cells stably expressing TRPV1 assessed by FDSS/μCELL fluorescence Ca2+ assay using Fluo-4 AM after 20 min compound incubation.	42732743
HEK293	IC50	0.69 μM	Inhibition of capsaicin-induced TRPV1 transmembrane currents in HEK293 cells stably expressing TRPV1 assessed by whole-cell patch-clamp electrophysiology at +100 mV after 1 min compound application. Inhibition of capsaicin-induced TRPV1 transmembrane currents in HEK293 cells stably expressing TRPV1 assessed by whole-cell patch-clamp electrophysiology at +100 mV after 1 min compound application.	42732743

In Vitro

STK436742 (0.005-100 μM; 20 min) inhibits Capsaicin (HY-10448)-induced TRPV1 calcium influx in TRPV1-expressing HEK293 cells with an FDSS IC₅₀ of 4.35 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS. Nr. 610266-79-0
Molecular Weight 306.32
Formel C₁₈H₁₄N₂O₃
SMILES

OC1=C2C(C=CC=C2)=CC=C1C(N/N=C/C3=CC=CC(O)=C3)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Guo Y, et al. Discovery and mechanism analysis of novel TRPV1 antagonists driven by multi-dimensional virtual screening and dynamic simulation. European journal of medicinal chemistry. 2026 Sep 10;320:119311.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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