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Art. -Nr.: HY-122646

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USP7-IN-2

Name: USP7-IN-2
Brand: MedChemExpress
SKU: HY-122646
Price: 1215.00 USD
Availability: InStock
Rating: 5 (1 reviews)

USP7-IN-2 (compound 4) is a non-competitive USP7 inhibitor with an IC₅₀ of 6 nM. USP7-IN-2 causes degradation of MDM2, stabilization of p53 and induction of p21 in multiple cell lines, and can be utilized in cancer research.

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CAS. Nr.: 2196243-57-7
Formel: C₂₉H₃₄N₆O₃
Molecular Weight:514.62

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

USP7-IN-2 Chemical Structure

CAS. Nr.: 2196243-57-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Deubiquitinase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
JeKo-1	IC₅₀	>20000 nM Compound: 27	Antiproliferative activity against human JeKo-1 cells harbouring p53 mutant Antiproliferative activity against human JeKo-1 cells harbouring p53 mutant	[PMID: 36306471]
MM1.S	IC₅₀	585.6 nM Compound: ALM4	Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation incubated for 3 days by SRB assay Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation incubated for 3 days by SRB assay	[PMID: 39133975]
REH	IC₅₀	20.3 nM Compound: 4	Antiproliferative activity against human REH cells with wild type p53 assessed as cell viability measured after 3 days by PMS-MTS assay Antiproliferative activity against human REH cells with wild type p53 assessed as cell viability measured after 3 days by PMS-MTS assay	[PMID: 39028938]
RS4-11	IC₅₀	>20000 nM Compound: 4	Antiproliferative activity against human RS4-11 cells with shp53 assessed as cell viability measured after 7 days by PMS-MTS assay Antiproliferative activity against human RS4-11 cells with shp53 assessed as cell viability measured after 7 days by PMS-MTS assay	[PMID: 39028938]
RS4-11	IC₅₀	69 nM Compound: 4	Antiproliferative activity against human RS4-11 cells with wild type p53 assessed as cell viability measured after 3 days by PMS-MTS assay Antiproliferative activity against human RS4-11 cells with wild type p53 assessed as cell viability measured after 3 days by PMS-MTS assay	[PMID: 39028938]

Chemical Information

CAS. Nr. 2196243-57-7
Molecular Weight 514.62
Formel C₂₉H₃₄N₆O₃
SMILES

O=C1C2=NN(C)C(C3=CC=C(CN)C=C3)=C2N=CN1CC4(O)CCN(C(C[C@H](C5=CC=CC=C5)C)=O)CC4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Gavory G, et al. Discovery and characterization of highly potent and selective allosteric USP7 inhibitors. Nat Chem Biol. 2018 Feb;14(2):118-125. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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