ZMF-10
ZMF-10 is a highly potent PAK1 inhibitor, with IC50s of 174 nM, 1.038 μM and 1.372 μM for PAK1, PAK2 and PAK3, respectively. ZMF-10 can inhibit PAK1 activity to affect PAK1-regulated apoptosis, ER-Stress and migration in MDA-MB-231 cells. ZMF-10 can be used for researching anticancer.
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- CAS. Nr.: 2415295-37-1
- Formel: C19H17F6N7O
- Molecular Weight:473.37
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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PAK1 174 nM (IC50) |
PAK2 1.038 μM (IC50) |
PAK3 1.372 μM (IC50) |
ZMF-10 (0-10 μM; 48 hours) exhibits potent antiproliferative activity in a dose-dependent manner[1].
ZMF-10 (20 μM; 24 hours) suppresses the phosphorylation of PAK1 at Ser199 and Thr212[1].
ZMF-10 (10-40 μM; 24 hours) downregulates the expression of ERK, and suppresses the phosphorylation of c-Raf, MEK and ERK; up-regulates the expression of Bax and downregulates the expression of Bcl-2; induces apoptosis in a dose-dependent manner with the increase of early and late apoptotic cell population[1].
ZMF-10 (10-40 μM; 24 hours) inhibits the PI3K-AKT-mTOR signaling with the decreasing phosphorylation of AKT and mTOR; inhibits JNK1/2 and cells migration in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231[1]
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Concentration:0-10 μM
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Incubation Time:48 hours
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Result:Exhibited potent antiproliferative activity in a dose-dependent manner with an IC50 value of 3.48 μM.
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Cell Line:MDA-MB-231[1]
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Concentration:20 μM
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Incubation Time:24 hours
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Result:Suppressed the phosphorylation of PAK1 at Ser199 and Thr212.
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Cell Line:MDA-MB-231[1]
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Concentration:10, 20 and 40 μM
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Incubation Time:24 hours
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Result:Downregulated the expression of ERK, and suppressed the phosphorylation of c-Raf, MEK and ERK; up-regulated the expression of Bax and downregulated the expression of Bcl-2.
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Cell Line:MDA-MB-231[1]
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Concentration:10, 20 and 40 μM
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Incubation Time:24 hours
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Result:Induced apoptosis in a dose-dependent manner with the increase of early and late apoptotic cell population.
Chemical Information
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CAS. Nr. 2415295-37-1
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Molecular Weight 473.37
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Formel C19H17F6N7O
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SMILES
O=C(NC1CCN(CC1)C2=C3C=NNC3=NC=N2)NC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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