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Cat. No.: HY-164527

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Si306

Si306 is a Src inhibitor with antitumor activity. Si306 reduces the phosphorylation of focal adhesion kinase (FAK) and the expression of epidermal growth factor receptor (EGFR), and inhibits the invasion of human glioblastoma (GBM).

For research use only. We do not sell to patients.

CAS No.: 1640012-88-9
Formula: C₂₅H₂₆BrClN₆OS
Molecular Weight:573.94

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Si306 Chemical Structure

CAS No.: 1640012-88-9

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Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Src Isoforms :

All EGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
SH-SY5Y	IC₅₀	0.34 μM Compound: 29	Antiproliferative activity against human SH-SY5Y cells after 24 hrs Antiproliferative activity against human SH-SY5Y cells after 24 hrs	[PMID: 25469771]
U-87MG ATCC	IC₅₀	1.9 μM Compound: 4	Cytotoxicity against human U87 cells assessed as reduction in cell viability after 72 hrs by trypan blue assay Cytotoxicity against human U87 cells assessed as reduction in cell viability after 72 hrs by trypan blue assay	[PMID: 28650650]
U-87MG ATCC	IC₅₀	17.3 μM Compound: 4	Cytotoxicity against human U87 cells assessed as reduction in cell viability after 24 hrs by trypan blue assay Cytotoxicity against human U87 cells assessed as reduction in cell viability after 24 hrs by trypan blue assay	[PMID: 28650650]
U-87MG ATCC	IC₅₀	6.8 μM Compound: 4	Cytotoxicity against human U87 cells assessed as reduction in cell viability after 48 hrs by trypan blue assay Cytotoxicity against human U87 cells assessed as reduction in cell viability after 48 hrs by trypan blue assay	[PMID: 28650650]

Chemical Information

CAS No. 1640012-88-9
Molecular Weight 573.94
Formula C₂₅H₂₆BrClN₆OS
SMILES

BrC1=CC(NC2=NC(SCCN3CCOCC3)=NC4=C2C=NN4CC(Cl)C5=CC=CC=C5)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nešović, et al. "Src Inhibitors Pyrazolo [3, 4-d] pyrimidines, Si306 and Pro-Si306, inhibit focal adhesion kinase and suppress human glioblastoma invasion in vitro and in vivo." Cancers 12.6 (2020): 1570. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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Si306

All Src Isoforms

All EGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Si306 Related Classifications

HY-164527 Related Classifications