SMART1
Based on 1 Customer Validation
SMART1 is a highly specific and CRBN-dependent PROTAC that can effectively degrade Smurf1. SMART1 can block the PDK1-Akt signaling pathway in KRAS mutant colorectal cancer. SMART1 can inhibit tumor growth in KRAS mutant colorectal cancer (CRC) xenograft models.
(Pink: Smurf1 ligand (HY-169049); Blue: Cereblon ligand (HY-14658); Black: linker).
For research use only. We do not sell to patients.
- Purity: 99.87%
- Formula: C40H35N9O7
- Molecular Weight:753.76
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
(Pink: Smurf1 ligand (HY-169049); Blue: Cereblon ligand (HY-14658); Black: linker).
Chemical Information
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Appearance Solid
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Molecular Weight 753.76
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Formula C40H35N9O7
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Color Light yellow to green yellow
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SMILES
CNC(C1=NC=CC(OC2=CC=C(C=C2)N3C=C(N=N3)C4=CC(NC(C5CCCN(C5)C6=C7C(N(C(C7=CC=C6)=O)C8CCC(NC8=O)=O)=O)=O)=CC=C4)=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (132.67 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3267 mL | 6.6334 mL | 13.2668 mL | 33.1671 mL |
| 5 mM | 0.2653 mL | 1.3267 mL | 2.6534 mL | 6.6334 mL | |
| 10 mM | 0.1327 mL | 0.6633 mL | 1.3267 mL | 3.3167 mL | |
| 15 mM | 0.0884 mL | 0.4422 mL | 0.8845 mL | 2.2111 mL | |
| 20 mM | 0.0663 mL | 0.3317 mL | 0.6633 mL | 1.6584 mL | |
| 25 mM | 0.0531 mL | 0.2653 mL | 0.5307 mL | 1.3267 mL | |
| 30 mM | 0.0442 mL | 0.2211 mL | 0.4422 mL | 1.1056 mL | |
| 40 mM | 0.0332 mL | 0.1658 mL | 0.3317 mL | 0.8292 mL | |
| 50 mM | 0.0265 mL | 0.1327 mL | 0.2653 mL | 0.6633 mL | |
| 60 mM | 0.0221 mL | 0.1106 mL | 0.2211 mL | 0.5528 mL | |
| 80 mM | 0.0166 mL | 0.0829 mL | 0.1658 mL | 0.4146 mL | |
| 100 mM | 0.0133 mL | 0.0663 mL | 0.1327 mL | 0.3317 mL |
SMART1 Related Classifications
HY-W998345 Related Classifications
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