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SAG

44 Cited Publications
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Based on 44 publication(s) in Google Scholar

SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo.

For research use only. We do not sell to patients.

  • Purity: 99.60%
  • CAS No.: 912545-86-9
  • Formula: C28H28ClN3OS
  • Molecular Weight:490.06
  • Storage:

    4°C, protect from light

    * In solvent : -80°C, 2 years; -20°C, 1 year (protect from light)

  • SAG Chemical Structure
    SAG Chemical Structure
  • Experimental Validation Results for SAG
  • Experimental Validation Results for SAG
  • Experimental Validation Results for SAG
  • Experimental Validation Results for SAG
  • Experimental Validation Results for SAG
  • Experimental Validation Results for SAG
CAS No.: 912545-86-9
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609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • SAG Chemical Structure
    SAG Chemical Structure
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  • 1/16

    SAG purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2024 Feb 15;22(1):123. [Abstract]

    Customer Validation
     qPCR detecting expression alterations of IL-6, MIP-2, and E-selectin in RS218 infected hBMECs with or without SAG pre-treatment (at 10 μM).

  • 1/16

    SAG purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2024 Feb 15;22(1):123. [Abstract]

    Customer Validation
     Western blot detecting expression of E-selectin, KRAS and ERK1/2 phosphorylation in RS218 infected hBMECs with or without SAG pre-treatment (at 10 μM).

  • 1/16

    SAG purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2024 Feb 15;22(1):123. [Abstract]

    Customer Validation
     IF assays showing the E-selectin and KRAS expression in brains of mice challenged by RS218 with or without SAG (10 mg/kg, i.v.; single dose) pre-treatment. The E-selection and KRAS were stained in red. CD31 was specifically applied for labeling the micro-vessels in green. The cell nucleus was stained in blue with DAPI. Scale bar = 50 μm

  • 1/16

    SAG purchased from MedChemExpress. Usage Cited in: Sci Adv. 2023 Jun 16;9(24):eadf6927. [Abstract]

    Customer Validation
     Representative immunofluorescent images of TdTomato (tdTom) and brachyury (T) at E10.5 in trunk cross sections of indicated genotypes with or without small molecule agonist (SAG, 20 mg/kg; i.p.) treatment. Scale bar, 100 μm.

  • 1/16

    SAG purchased from MedChemExpress. Usage Cited in: Cell Res. 2022 Mar;32(3):288-301. [Abstract]

    Customer Validation
     SAG (5-200 nM)-induced Gli1 expression is independent of extracellular Ca2+ concentration. Sub-confluent NIH3T3 cells were serum-starved in 0.5% FCS overnight and switched to normal DMEM or Ca2+-free DMEM containing indicated concentration of SAG. Cells were harvested for RNA extraction after 6 hours.

  • 1/16

    SAG purchased from MedChemExpress. Usage Cited in: Development. 2018 Sep 20;145(18). pii: dev164830. [Abstract]

    Customer Validation
     WT MEF cells are treated with 100 nM SAG, 0.1mM ATP, or 0.1mM NHATP for 10 min (U). p-Creb, total Creb and Tubulin protein levels are detected by Western blotting.

  • SAG