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SC79

334 Cited Publications
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Based on 334 publication(s) in Google Scholar

SC79, a unique specific and BBB permeable Akt activator, activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt.

For research use only. We do not sell to patients.

  • Purity: 98.0%
  • CAS No.: 305834-79-1
  • Formula: C17H17ClN2O5
  • Molecular Weight:364.78
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years

    * The compound is unstable in solutions, freshly prepared is recommended.

  • SC79 Chemical Structure
    SC79 Chemical Structure
  • Experimental Validation Results for SC79
  • Experimental Validation Results for SC79
  • Experimental Validation Results for SC79
  • Experimental Validation Results for SC79
  • Experimental Validation Results for SC79
  • Experimental Validation Results for SC79
  • Experimental Validation Results for SC79
  • Experimental Validation Results for SC79
  • Experimental Validation Results for SC79
  • Experimental Validation Results for SC79
  • Experimental Validation Results for SC79
CAS No.: 305834-79-1
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  • SC79 Chemical Structure
    SC79 Chemical Structure
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    SC79 purchased from MedChemExpress. Usage Cited in: Environ Pollut. 2023 Apr 15:323:121306. [Abstract]

    Customer Validation
     SC79 induces mitochondria dysfunction and apoptosis in the heart of zebrafish embryos (Fig D and E).

  • 1/16

    SC79 purchased from MedChemExpress. Usage Cited in: Polymers. 2023 Mar 28;15(7):1681. [Abstract]

    Customer Validation
     SC79 (2.5 μM; 4, 6, 24 h) significantly increases the expression of p-AKT and p-AKT/AKT while decreases p-ERK expression and the ratio of p-ERK/ERK ratio in T84 cells.

  • 1/16

    SC79 purchased from MedChemExpress. Usage Cited in: Polymers. 2023 Mar 28;15(7):1681. [Abstract]

    Customer Validation
     Effect of SC79 (1–10 μM) on T84 cell viability in the absence of COS.

  • 1/16

    SC79 purchased from MedChemExpress. Usage Cited in: Toxicology. 2019 May 1:419:32-39. [Abstract]

    Customer Validation
     HaCaT cells are treated with SC79 at 10 μM for 0, 0.5, 1, and 2 h, following arecoline treatment of 48 h. Proteins are extracted and used for Western blotting for phosphorylated and total Akt, mTOR, 4E-BP1, and cyclin D1. Akt, mTOR, 4E-BP1 and GAPDH are used as the internal control for p-Akt, p-mTOR, p-4E-BP1 and cyclin D1, respectively.

  • 1/16

    SC79 purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2019 May;19(5):4091-4100. [Abstract]

    Customer Validation
     Western blot analysis demonstrating the protein levels of LC3, p62, AKT, p-AKT, mTOR and p-mTOR following treatment with Aβ1-42, 3-MA, SC79 and SC79 + RAPA for 48 h, and the expression of the AKT/mTOR signaling pathway‑associated proteins of AKT, p-AKT, mTOR and p-mTOR following treatment with Aβ1-42, 3-MA, SC79 and SC79 + RAPA for 48 h.

  • 1/16

    SC79 purchased from MedChemExpress. Usage Cited in: Oncol Rep. 2019 Feb;41(2):811-818. [Abstract]

    Customer Validation
     Cells are cultured with and without CAR/SC79 for 24 h, and cell lysates are prepared and analyzed by western blotting to detect the levels of MDM2 and p53Ser15.

  • 1/16

    SC79 purchased from MedChemExpress. Usage Cited in: Acta Biomater. 2018 Nov:81:278-292. [Abstract]

    Customer Validation
     PC12 cells are pretreated with 740-YP (30 μM), or SC79 (13.7 μM), or 3BDO (100 μM) for 1 h, and for the duration of GO (50 μg/mL) incubation for 24 h. LC3 turnover is detected by western blotting.

  • 1/16

    SC79 purchased from MedChemExpress. Usage Cited in: Nutrients. 2018 Sep 23;10(10):1366. [Abstract]

    Customer Validation
     Competition tests of SC79, PHT-427, AT7867, and AKT inhibitor VIII with the CGA probe against enriched AKT by CGA-modified functionalized MMs. Bands of AKT are detected by Western blot.

  • 1/16

    SC79 purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Oct:106:755-762. [Abstract]

    Customer Validation
     LTEP-a-2 cells are exposed to SC79 and GSK3β and AKT phosphorylation levels are significantly increased.

  • 1/16

    SC79 purchased from MedChemExpress. Usage Cited in: RSC Adv. 2017 Aug 11.

    Customer Validation
     Phillygenin (Phi) modulates phosphorylation of Akt in BEAS-2B cells. BEAS-2B cells are serum-starved overnight and then treated with SC79 and different doses of Phi for 4 h. Thr 308 and Ser 473 phosphorylation of Akt and total Akt are detected by western blot. β-Actin is used as an internal control.

  • 1/16

    SC79 purchased from MedChemExpress. Usage Cited in: Toxicology. 2017 Jul 1:386:72-83. [Abstract]

    Customer Validation
     Western blot assays and quantitative analysis show that BPDE treatment reduces the expression levels of AKT and eNOS; while simultaneous addition of SC79 significantly increases their expression.

  • SC79