1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. BI-2545

BI-2545 

Cat. No.: HY-124772
Handling Instructions

BI-2545 is a potent autotaxin (ATX) inhibitor that significantly reduces LPA, with IC50s of 2.2 nM and 3.4 nM for human ATX and rat ATX, respectively.

For research use only. We do not sell to patients.

BI-2545 Chemical Structure

BI-2545 Chemical Structure

CAS No. : 2162961-71-7

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BI-2545 is a potent autotaxin (ATX) inhibitor that significantly reduces LPA, with IC50s of 2.2 nM and 3.4 nM for human ATX and rat ATX, respectively[1].

IC50 & Target

C50: 2.2 nM (human ATX), 3.4 nM (rat ATX)[1]

In Vitro

BI-2545 displays good potency in the LPA and rat whole blood assay with IC50s of 29 nM and 96 nM, respectively[1].

In Vivo

BI-2545 (10 mg/kg; p.o.) has high and sustained in vivo efficacy in reducing LPAs[1].
BI-2545 (10 mg/kg; p.o.) has a half-life of t1/2=3.4 hours[1].

Animal Model: Rat[1]
Dosage: 10 mg/kg
Administration: Oral administration
Result: Reduces the sum of the plasma LPA species up to 90%.
Molecular Weight

527.42

Formula

C₂₃H₁₉F₆N₅O₃

CAS No.

2162961-71-7

SMILES

O=C(N1C[[email protected]]2([H])[[email protected]](CNC(C3=CC=C(NN=N4)C4=C3)=O)[[email protected]]2([H])C1)OCC5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

BI-2545BI2545BI 2545Phosphodiesterase (PDE)autotaxinATXLPAInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
BI-2545
Cat. No.:
HY-124772
Quantity:
MCE Japan Authorized Agent: