G6374
G6374 is an IRE1 PROTAC degrader with a DC50 of 0.04 μM. G6374 induces efficient ubiquitination and degradation of IRE1. G6374 selectively inhibits IRE1-dependent cancer-cell proliferation.
(Pink: Ligands for Target Protein for PROTAC and IRE1 ligand (HY-180780); Blue: Ligands for E3 Ligase and VHL ligand (HY-125845); Black: linker (HY-W041652)).
For research use only. We do not sell to patients.
- Formula: C47H66N10O5S
- Molecular Weight:883.16
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
DC50: 0.04 μM (IRE1)[1]
Chemical Information
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Molecular Weight 883.16
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Formula C47H66N10O5S
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SMILES
CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCN4CCN(CC4)[C@H]5CC[C@@H](CC5)NC6=NC7=C(C=N6)C=CC(N7C(C)C)=O)=O)=O)O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
G6374 Related Classifications
HY-180787 Related Classifications
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