Erg - ETS transcription factor Gene

Also Known as D030036I24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13876

Summary

Enables chromatin binding activity. Acts upstream of or within cell migration; mesenchyme development; and positive regulation of blood vessel remodeling. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and skeleton. Used to study osteoarthritis. Human ortholog(s) of this gene implicated in myeloid leukemia. Orthologous to human ERG (ETS transcription factor ERG). [provided by Alliance of Genome Resources, Apr 2022]

Erg Products (6)

mRNA Protein Name
NM_001302152.1 NP_001289081.1 transcriptional regulator ERG isoform 2
NM_001302153.1 NP_001289082.1 transcriptional regulator ERG isoform 3
NM_001302154.1 NP_001289083.1 transcriptional regulator ERG isoform 4
NM_001302179.1 NP_001289108.1 transcriptional regulator ERG isoform 5
NM_001302183.1 NP_001289112.1 transcriptional regulator ERG isoform 6
NM_133659.3 NP_598420.1 transcriptional regulator ERG isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
22932696 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11791185 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
28811219 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcriptional regulator ERG

  • avian erythroblastosis virus E-26 (v-ets) oncogene related

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0148A Halofantrine hydrochloride Inhibitor 99.90% Yes
HY-A0148 Halofantrine Inhibitor / Unkown
HY-A0148AR Halofantrine hydrochloride (Standard) Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-Y0282 Sodium bromide 99.2% Phase 3

Pre-clinical Phase

Bioactive Molecules (34)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W193545A ERG240 Inhibitor 98.0% Unkown
HY-162351 EBP-IN-1 Inhibitor 99.77% Unkown
HY-159730 ERG245 Inhibitor 99.49% Unkown
HY-122234 VPC-18005 Inhibitor 99.80% Unkown
HY-N7848 Linoleamide Inhibitor 99.4% Unkown
HY-112158 NSC139021 99.77% Unkown
HY-16915 RPR-260243 Activator 99.37% Unkown
HY-121964 cis-Piperidine-2,3-dicarboxylic acid Agonist 95.0% Unkown
HY-139893 ERGi-USU-6 mesylate Inhibitor 95.0% Unkown
HY-108592 UCL 2077 Inhibitor 98.91% Unkown
HY-116445 UNC9975 Agonist / Unkown
HY-117744 NMS-P645 Inhibitor / Unkown
HY-124057 RO5126946 Activator / Unkown
HY-144694 HDAC/HSP90-IN-3 Inhibitor / Unkown
HY-145814 HSP90-IN-9 Inhibitor / Unkown
HY-159585 CYP51-IN-20 Inhibitor / Unkown
HY-175663 EYE-002 Inhibitor / Unkown
HY-175664 EYE-003 Inhibitor / Unkown
HY-180918 ERG-IN-4 / Unkown
HY-180919 ERG-IN-5 Inhibitor / Unkown
HY-181103 ERG-IN-6 / Unkown
HY-183202 NCD38 / Unkown
HY-184190 ERG-IN-7 Inhibitor / Unkown
HY-P1426 AmmTX3 Inhibitor / Unkown
HY-P5806 Ergtoxin-1 Antagonist / Unkown
HY-RS04491 ERG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04492 ERG28 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04493 ERGIC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04494 ERGIC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W749520 Zymosterone / Unkown
HY-117523 (Z)-RG-13022 Inhibitor / Unkown
HY-184314 Antifungal agent-166 Inhibitor / Unkown
HY-RS16711 Erg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23146 Erg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991886 ANX-M1 (Human IgG1) Inhibitor ≥99.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Erg NCBI NCBI:2078