Cat. No.: HY-119458

Luotonin A

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Luotonin A is an antiviral and antiphytopathogenic fungus agent. Luotonin A has good antiviral activity against tobacco mosaic virus (TMV). Luotonin A also has certain inhibitory activity on topoisomerase I and topoisomerase II. Luotonin A shows antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 205989-12-4
Formula: C₁₈H₁₁N₃O
Molecular Weight:285.30

Storage:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

Data Sheet (274 KB)

Luotonin A Chemical Structure

CAS No.: 205989-12-4

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Sample (0.1mg)

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(In Japan)

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

All Topoisomerase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	61.25 μM Compound: 10	Cytotoxicity against Homo sapiens (human) A549 cells assessed as growth inhibition after 48 hr by MTT assay Cytotoxicity against Homo sapiens (human) A549 cells assessed as growth inhibition after 48 hr by MTT assay	10.1007/s00044-012-0018-x
CCRF-CEM	GI₅₀	≥40 μM Compound: 1a, luotonin A	Growth inhibition of human CEM cells by Alamar blue assay Growth inhibition of human CEM cells by Alamar blue assay	[PMID: 17418582]
CEM/C2	GI₅₀	>40 μM Compound: 1a, luotonin A	Growth inhibition of topoisomerase 1 mutated CEM/C2 cells by Alamar blue assay Growth inhibition of topoisomerase 1 mutated CEM/C2 cells by Alamar blue assay	[PMID: 17418582]
HCT-116	IC₅₀	51.11 μM Compound: 36	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell proliferation Antiproliferative activity against human HCT-116 cells assessed as reduction in cell proliferation	[PMID: 36375335]
HEK293	IC₅₀	58 μM Compound: 1	Cytotoxicity against HEK cells after 72 hrs by MTT assay Cytotoxicity against HEK cells after 72 hrs by MTT assay	[PMID: 25757092]
HeLa	GI₅₀	3 μM Compound: 1a, luotonin A	Growth inhibition of HeLa cells after 4 days Growth inhibition of HeLa cells after 4 days	[PMID: 17418582]
HeLa	IC₅₀	5.94 μM Compound: 1	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 25757092]
HeLa	IC₅₀	6.4 μM Compound: 1	Inhibition of HDAC1/2 in human HeLa cells using color de lys as substrate after 30 mins by colorimetric analysis Inhibition of HDAC1/2 in human HeLa cells using color de lys as substrate after 30 mins by colorimetric analysis	[PMID: 25757092]
HeLa	IC₅₀	3 μM Compound: 36	Cytotoxicity against human HeLa cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay	[PMID: 36375335]
HL-60	IC₅₀	>100 μM Compound: 36	Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 36375335]
K562	IC₅₀	28.8 μM Compound: 1	Cytotoxicity against human K562 cells after 72 hrs by MTT assay Cytotoxicity against human K562 cells after 72 hrs by MTT assay	[PMID: 25757092]
MCF7	GI₅₀	3 μM Compound: 1a, luotonin A	Growth inhibition of MCF7 cells after 4 days Growth inhibition of MCF7 cells after 4 days	[PMID: 17418582]
MCF7	GI₅₀	5 μM Compound: 1a, luotonin A	Growth inhibition of adriamycin-resistant MCF7 cells after 4 days Growth inhibition of adriamycin-resistant MCF7 cells after 4 days	[PMID: 17418582]
MCF7	IC₅₀	9.28 μM Compound: 1	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 25757092]
MCF7	IC₅₀	3 μM Compound: 36	Cytotoxicity against human MCF7 cells assessed as reduction in cell growth incubated for 5 days by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell growth incubated for 5 days by MTT assay	[PMID: 36375335]
NCI/ADR-RES	IC₅₀	3 μM Compound: 36	Antiproliferative activity against human NCI-ADR-RES cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human NCI-ADR-RES cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 36375335]
NCI-H460	IC₅₀	67 μM Compound: 1a	In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 1 hour exposure) In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 1 hour exposure)	[PMID: 15501036]
NCI-H460	IC₅₀	7.7 μM Compound: 1a	In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 72 hours exposure) In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 72 hours exposure)	[PMID: 15501036]
NCI-H460	IC₅₀	7.7 μM Compound: 36	Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 48 hrs by SRB assay Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 48 hrs by SRB assay	[PMID: 36375335]
P388	IC₅₀	1.8 μg/mL Compound: 1 (luotonin A)	Cytotoxic activity against mouse leukemia P-388 cells Cytotoxic activity against mouse leukemia P-388 cells	[PMID: 14980663]
P388	IC₅₀	1.8 μg/mL Compound: Luotonin A	Cytotoxicity against mouse P388 cells assessed as reduction in cell growth Cytotoxicity against mouse P388 cells assessed as reduction in cell growth	[PMID: 30917303]
P388	IC₅₀	6.3 μM Compound: 53	Antiproliferative activity gainst mouse P388 cells assessed as cell growth inhibition Antiproliferative activity gainst mouse P388 cells assessed as cell growth inhibition	[PMID: 35413618]
P388	IC₅₀	1.8 μg/mL Compound: 36	Cytotoxicity against mouse P388 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against mouse P388 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 36375335]
SK-N-SH	IC₅₀	61.08 μM Compound: 10	Cytotoxicity against Homo sapiens (human) SK-N-SH cells assessed as growth inhibition after 48 hr by MTT assay Cytotoxicity against Homo sapiens (human) SK-N-SH cells assessed as growth inhibition after 48 hr by MTT assay	10.1007/s00044-012-0018-x

Chemical Information

CAS No. 205989-12-4
Appearance Solid
Molecular Weight 285.30
Formula C₁₈H₁₁N₃O
Color White to off-white
SMILES

O=C1N2C(C3=C(C2)C=C4C(C=CC=C4)=N3)=NC5=CC=CC=C51
Structure Classification
- Alkaloids
- Quinoline Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 2.5 mg/mL (8.76 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.5051 mL

17.5254 mL

35.0508 mL

5 mM

0.7010 mL

3.5051 mL

7.0102 mL

10 mM

---

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

Concentration

Volume

Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage
mg/kg
Animal Weight (Per Animal)
g
Dosing Volume (Per Animal)
μL
Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hao Y, et al. Luotonin A and Its Derivatives as Novel Antiviral and Antiphytopathogenic Fungus Agents. J Agric Food Chem. 2020 Aug 19;68(33):8764-8773. [Content Brief]

[2]. Cagir A, et al. A naturally occurring human DNA topoisomerase I poison. J Am Chem Soc. 2003 Nov 12;125(45):13628-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.5051 mL	17.5254 mL	35.0508 mL	87.6271 mL
DMSO	5 mM	0.7010 mL	3.5051 mL	7.0102 mL	17.5254 mL

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Luotonin A

High-Throughput Bioactive Compound Library

All Topoisomerase Isoforms