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Cat. No.: HY-W042301S

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Xipamide-d₆

Xipamide-d₆ is the deuterated-labeled Xipamide (HY-W042301). Xipamide is an orally active carbonic anhydrase (CA) inhibitor and Na⁺/Cl^--potassium cotransporter inhibitor, with diuretic and antihypertensive effects. Xipamide reduces NaCl reabsorption by inhibiting the Cl^-/NaCO^3- anion exchanger, promoting potassium and magnesium excretion while increasing calcium reabsorption. Xipamide is cleared primarily via the renal route and causes a transient decrease in glomerular filtration rate under specific conditions. Xipamide can be applied in research related to cardiovascular diseases, hypertension, advanced renal failure, and cirrhosis with ascites.

For research use only. We do not sell to patients.

CAS No.: 1330262-09-3
Formula: C₁₅H₉D₆ClN₂O₄S
Molecular Weight:360.85

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Xipamide-d₆ Chemical Structure

CAS No.: 1330262-09-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Application
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target

^[1]^[2]

CAs

All Carbonic Anhydrase Isoforms :

All Endothelin Receptor Isoforms :

ET_A
ET_B

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 1330262-09-3
Unlabeled CAS 14293-44-8
Molecular Weight 360.85
Formula C₁₅H₉D₆ClN₂O₄S
SMILES

C(NC1=C(C([2H])([2H])[2H])C=CC=C1C([2H])([2H])[2H])(=O)C2=CC(S(N)(=O)=O)=C(Cl)C=C2O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Taouil K, et al. Inhibition by xipamide of amiloride-induced acidification in cultured rat cardiocytes. Eur J Pharmacol. 1997;324(2-3):289-294. [Content Brief]

[2]. Nazaret C, et al. Inhibition of the Cl-/NaCO3-anion exchanger by xipamide in human red blood cells[J]. European journal of pharmacology, 1987, 144(3): 353-362.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Xipamide-d6

All Carbonic Anhydrase Isoforms

All Endothelin Receptor Isoforms

Biological Activity

Description

IC50 & Target

Application

Chemical Information

Purity & Documentation

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Xipamide-d6 Related Classifications

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