(2S)-OMPT
(2S)-OMPT, Lysophosphatidic acid analogue, is a LPA3 G-protein-coupled receptor agonist. (2S)-OMPT selectively activates LPA3 G-protein-coupled receptor to trigger downstream cellular signaling events. (2S)-OMPT induces calcium, IL-6 release in cancer cells and activates MAPK and Akt signaling pathways. (2S)-OMPT can be used for the research of ovarian cancer.
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- CAS No.: 645408-61-3
- Formule: C22H43O6PS
- Masse moléculaire:466.61
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
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IL-6 |
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Cell Line
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Type | Value | Description | References |
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| HEK-293T | EC50 |
276 nM
Compound: 9, OMPT
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Agonist activity at human LPA3 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assay
Agonist activity at human LPA3 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assay
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10.1039/C4MD00333K |
(2S)-OMPT (0.001-10000 nM) induces calcium release in human ovarian cancer OVCAR3 cells with an EC50 of 9.0 nM[1].
(2S)-OMPT (0.01-1 μM) activates Akt and MAPK phosphorylation in human ovarian cancer OVCAR3 cells[1].
(2S)-OMPT (0.01-10 μM) induces IL-6 release in human ovarian cancer OVCAR3 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 645408-61-3
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Masse moléculaire 466.61
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Formule C22H43O6PS
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SMILES
CCCCCCCC/C=C\CCCCCCCC(OC[C@H](OC)COP(O)(S)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(2S)-OMPT Related Classifications
HY-120967A Related Classifications
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