Antimalarial agent 25
Antimalarial agent 25 is an orally active 1,4-naphthoquinones derivative with antimalarial activity. Antimalarial agent 25 shows cytotoxicity against P. falciparum. Antimalarial agent 25 inhibits P. burghei induced parasitemia in vivo.
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- CAS No.: 2944456-41-9
- Formule: C21H18N4O3
- Masse moléculaire:374.39
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Activité biologique
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Chemical Information
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | CC50 |
289.2 μM
Compound: 8
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Cytotoxicity against human HepG2 cells incubated for 24 hrs by MTT assay
Cytotoxicity against human HepG2 cells incubated for 24 hrs by MTT assay
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[PMID: 37130472] |
| Vero | CC50 |
400.6 μM
Compound: 8
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Cytotoxicity against African green monkey Vero cells incubated for 24 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells incubated for 24 hrs by MTT assay
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[PMID: 37130472] |
Antimalarial agent 25 (compound 8) inhibits P. falciparum with IC50 of 4.2 μM, while shows CC50 on mammalian cells with CC50s of 289.2 μM (HepG2), and 400.6 μM (Vero), respectively[1].
Antimalarial agent 25 (compound 8) (15.62-1000 μM; 2 h) shows hemolytic activity below 40% at concentrations from 15.6 to 250 μM in uninfected human erythrocytes[1].
Antimalarial agent 25 (compound 8) (30-0.411 μg/mL; 48 h) causes morphological changes such as complete cytoplasmic degradation and loss of membrane integrity in the W2 strain of P. falciparum[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:W2 strain of P. falciparum (CQ-resistant)
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Concentration:30 - 0.411 μg/mL
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Incubation Time:48 h
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Result:Presented completely degraded cytoplasm with loss of membrane integrity, dense cytoplasm with some possible undefined organelles in degenerating stage, and a possible deteriorated food vacuole.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice infected with Plasmodium berghei ANKA[1]
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Dosage:30 mg/kg
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Administration:Oral administration; for 4 consecutive days
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Result:Partly reduced P. berghei infection.
Parasitemia decreased by 33% on the seventh day (post-treatment).
Chemical Information
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CAS No. 2944456-41-9
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Masse moléculaire 374.39
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Formule C21H18N4O3
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SMILES
COC1=CC=C(C=C1)C2=CN(N=N2)CCNC3=CC(C4=CC=CC=C4C3=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antimalarial agent 25 Related Classifications
HY-149938 Related Classifications
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