AS601245 TFA
Based on 9 publication(s) in Google Scholar
AS601245 TFA is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 TFA exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties.
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- CAS No.: 345987-16-8
- Formule: C24H18F6N6O4S
- Masse moléculaire:600.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) AS601245 TFA
More- Nat Commun. 2025 Jun 2;16(1):5101. [Abstract]
- Nat Commun. 2021 Nov 16;12(1):6607. [Abstract]
- EMBO Mol Med. 2025 Nov 26. [Abstract]
- Cell Rep. 2022 Nov 22;41(8):111707. [Abstract]
- J Ethnopharmacol. 2024 Jan 10;318(Pt A):116901. [Abstract]
- Cell Biol Toxicol. 2023 Jun;39(3):907-928. [Abstract]
- ACS Omega. 2024 Jun 18;9(26):28311-28322. [Abstract]
- Npj Viruses. 2025 Sep 18;3(1):69. [Abstract]
- Theriogenology. 2022 Apr 15:183:108-119. [Abstract]
Activité biologique
AS601245, an anti-Inflammatory JNK inhibitor, and Clofibrate have a synergistic effect in inducing cell responses and in affecting the gene expression profile in CaCo-2 colon cancer cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
AS601245 (0.3-10 mg/kg; p.o.) is a potent inhibitor of LPS-induced TNF-α release in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C3H/HEN mice[1]
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Dosage:0.3, 1, 3, or 10 mg/kg
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Administration:P.o.
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Result:Decreased the TNF-α release in a dose-dependent manner.
Chemical Information
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CAS No. 345987-16-8
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Masse moléculaire 600.49
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Formule C24H18F6N6O4S
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SMILES
N#CC(C1=CC=NC(NCCC2=CC=CN=C2)=N1)C3=NC4=CC=CC=C4S3.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (9)
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Journal Impact Factor
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Most Recent
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Nat Commun
Myocardial mitochondrial antiviral signaling protein promotes heart Ischemia-reperfusion injury via RIG-I signaling in mice. [Abstract]2025 Jun 2;16(1):5101. PMID: 40456736 -
Nat Commun
Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation. [Abstract]2021 Nov 16;12(1):6607. PMID: 34785661 -
EMBO Mol Med
Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in mice. [Abstract]2025 Nov 26. PMID: 41299101 -
Cell Rep
circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells. [Abstract]2022 Nov 22;41(8):111707. PMID: 36417875 -
J Ethnopharmacol
Shenqisherong pill ameliorates neuronal apoptosis by inhibiting the JNK/caspase-3 signaling pathway in a rat model of cervical cord compression. [Abstract]2024 Jan 10;318(Pt A):116901. PMID: 37437792 -
Cell Biol Toxicol
Shikonin inhibits neuronal apoptosis via regulating endoplasmic reticulum stress in the rat model of double-level chronic cervical cord compression. [Abstract]2023 Jun;39(3):907-928. PMID: 35028790 -
ACS Omega
The Role and Efficacy of JNK Inhibition in Inducing Lung Cancer Cell Death Depend on the Concentration of Cisplatin. [Abstract]2024 Jun 18;9(26):28311-28322. PMID: 38973918 -
Npj Viruses
2025 Sep 18;3(1):69. PMID: 40968155 -
Theriogenology
Signaling pathways of Periplaneta americana peptide resist H2O2-induced apoptosis in pig-ovary granulosa cells through FoxO1. [Abstract]2022 Apr 15:183:108-119. PMID: 35247848
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AS601245 TFA Related Classifications
HY-11010A Related Classifications
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